DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and si:ch211-154o6.3

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_001038496.1	Gene:	si:ch211-154o6.3 / 563854	ZFINID:	ZDB-GENE-030131-1030	Length:	521	Species:	Danio rerio

Alignment Length:	410	Identity:	108/410 - (26%)
Similarity:	157/410 - (38%)	Gaps:	102/410 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 QILAEPRSDRPKRGRDGNMP----PIASPWKAAYMRQHIIEMNWRSRPVRKPK----VLKGHDDH 996
            :|..|.|  |.....|||..    ....|.......|...|...|.:...|.|    .|:||.|
Zfish    84 KIAREER--RENEASDGNQTDGRGETNLPVSLTEEEQEDAEFRSRKQTWEKAKFRLRALEGHSD- 145

  Fly   997 VITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGV-----------------WSSQMS 1044
            :|||.....|.::|||.|.|:|||........|.|.||:|||                 :.....
Zfish   146 IITCAVAVDNLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCAPPPESCRRLARAFDLADK 210

  Fly  1045 GNIIISGSTDRTLKVWDMDSGACV---HTLQGHTSTVRCMHLHGSK-VVSGSRDATLRVW---DI 1102
            ...::|||||..:|:|.:.||.||   :|....||.  |....|.. :|:||....|:||   .:
Zfish   211 ERFVLSGSTDCCVKIWALSSGQCVKSIYTFNAVTSL--CFIPEGEGFIVTGSDAGKLQVWSWSSL 273

  Fly  1103 EQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWH-----PERQECLHT------------ 1150
            |....::   .||.||..:|..|.|:.||:.:..|.:|.     ||....||.
Zfish   274 ENWLSVN---AHLDAVTTLQSHGPLVFSGSAEGSVCVWEVCDEGPEPLRRLHLWGPEVTGCGGED 335

  Fly  1151 -LQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQN----ILVS 1210
             |.|..  |.|.:.|.:.:..|.  .|||:.:..||  ..|.:.:.|.|:|:....|    :|::
Zfish   336 GLNGRL--VLSPRGDRVFLSCGK--ASIRILNWRTG--VMTRLANHSSTAGVTDCVNQIPGLLIA 394

  Fly  1211 -----GNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTV---KLWDVKT 1267
                 .|.:||:.::.:.  ||...:|                   :||||...:   ..|...:
Zfish   395 SCFDLANGESTINLFSLP--QCKYLVS-------------------LTSSDLPRILCFAAWLTAS 438

  Fly  1268 GDFIRNLVALDSGGSGGVVW 1287
            ||.     ...:||...:||
Zfish   439 GDH-----RWVTGGRDLIVW 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689
		WD40	<981..1274	CDD:225201	93/350 (27%)
		WD40	988..1264	CDD:238121	89/333 (27%)
		WD40 repeat	998..1033	CDD:293791	14/34 (41%)
		WD40 repeat	1039..1073	CDD:293791	12/36 (33%)
		WD40 repeat	1078..1112	CDD:293791	9/37 (24%)
		WD40 repeat	1119..1152	CDD:293791	11/50 (22%)
		WD40 repeat	1158..1192	CDD:293791	10/33 (30%)
		WD40 repeat	1200..1232	CDD:293791	8/40 (20%)
		WD40 repeat	1241..1263	CDD:293791	4/24 (17%)
si:ch211-154o6.3	NP_001038496.1	WD40	<136..>378	CDD:225201	74/253 (29%)
		WD40	<137..315	CDD:295369	57/183 (31%)
		WD40 repeat	147..181	CDD:293791	13/33 (39%)
		WD40 repeat	188..237	CDD:293791	11/48 (23%)
		WD40 repeat	243..278	CDD:293791	11/36 (31%)
		WD40 repeat	286..322	CDD:293791	10/35 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910