DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and FBXW7

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_001336727.1	Gene:	FBXW7 / 55294	HGNCID:	16712	Length:	707	Species:	Homo sapiens

Alignment Length:	746	Identity:	435/746 - (58%)
Similarity:	499/746 - (66%)	Gaps:	108/746 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   625 GSVGANPTAS------------------VRQR------RNGSSDVVHLEVVVEEGAGGGDG---- 661
            ||:..||::|                  :||:      |||       |||..|...||..
Human    17 GSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNG-------EVVGVEPRPGGQNDSQQ 74

  Fly   662 GVVEPGD---FSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPI 723
            |.:|..:   .|.:|     |...|..:.||       :....|..:....|..:||....|...
Human    75 GQLEENNNRFISVDE-----DSSGNQEEQEE-------DEEHAGEQDEEDEEEEEMDQESDDFDQ 127

  Fly   724 SLSLSSASAGFTEYSLTNPSSLMS---HQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDN 785
            |...|.........|:||.||::.   ||....|          |:.|.....::
Human   128 SDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPF----------YTKTTKMKRKL---------- 172

  Fly   786 CRKRIAYDFASTPRSSQHLG--PTAVLSVTPSSHLT--SSTP----------GSALGRRTPRSVP 836
                   |..|..||.. ||  |..|...|.::.|.  |:||          |....||...||
Human   173 -------DHGSEVRSFS-LGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSV- 228

  Fly   837 SRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELAL 901
               .||..||.||..||.||..|:|||||.|||.|:|:||:|||:|||||||||||||||:||||
Human   229 ---QPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELAL 290

  Fly   902 FVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRP---KRGRDGNMPPIAS 963
            :|||:|||||||:||||||.||.|.:|||||:|||::..|      |.|   ||.:......|.|
Human   291 YVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGI------DEPLHIKRRKVIKPGFIHS 349

  Fly   964 PWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCL 1028
            |||:||:|||.|:.|||...::.|||||||||||||||||.|||||||||||||||||||.||||
Human   350 PWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCL 414

  Fly  1029 RTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSR 1093
            |||||||||||||||..|||||||||||||||:.::|.|:|||.||||||||||||..:||||||
Human   415 RTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSR 479

  Fly  1094 DATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRV 1158
            ||||||||||.|.|||||:||:||||||||||:.:||||||:|||:|.||.:.||||||||||||
Human   480 DATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRV 544

  Fly  1159 YSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDIT 1223
            |||||||:|||||||||||||||||||||.|||.|||||||||||:.|||||||||||||:|||.
Human   545 YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIK 609

  Fly  1224 TGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWR 1288
            ||||||||.|||||.|||||||||..||:||||||||||||:|||:||||||.|:||||||||||
Human   610 TGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWR 674

  Fly  1289 IRANDTKLICAVGSRNGTEETKLMVLDFDVE 1319
            |||::|||:||||||||||||||:||||||:
Human   675 IRASNTKLVCAVGSRNGTEETKLLVLDFDVD 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	36/45 (80%)
		WD40	<981..1274	CDD:225201	245/292 (84%)
		WD40	988..1264	CDD:238121	236/275 (86%)
		WD40 repeat	998..1033	CDD:293791	32/34 (94%)
		WD40 repeat	1039..1073	CDD:293791	25/33 (76%)
		WD40 repeat	1078..1112	CDD:293791	28/33 (85%)
		WD40 repeat	1119..1152	CDD:293791	23/32 (72%)
		WD40 repeat	1158..1192	CDD:293791	31/33 (94%)
		WD40 repeat	1200..1232	CDD:293791	27/31 (87%)
		WD40 repeat	1241..1263	CDD:293791	18/21 (86%)
FBXW7	NP_001336727.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..151		36/152 (24%)
		F-box-like	281..325	CDD:403981	34/43 (79%)
		WD40	374..650	CDD:238121	236/275 (86%)
		WD 1	378..418		37/39 (95%)
		WD40 repeat	384..419	CDD:293791	32/34 (94%)
		WD 2	420..456		27/35 (77%)
		WD40 repeat	425..459	CDD:293791	25/33 (76%)
		WD 3	459..498		33/38 (87%)
		WD40 repeat	464..498	CDD:293791	28/33 (85%)
		WD 4	500..536		25/35 (71%)
		WD40 repeat	505..538	CDD:293791	23/32 (72%)
		WD 5	539..578		36/38 (95%)
		WD40 repeat	544..578	CDD:293791	31/33 (94%)
		WD 6	580..618		33/37 (89%)
		WD40 repeat	586..618	CDD:293791	27/31 (87%)
		WD 7	622..659		30/36 (83%)
		WD40 repeat	627..649	CDD:293791	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144347
Domainoid	1	1.000	101	1.000	Domainoid score	I7003
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I475
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002731
OrthoInspector	1	1.000	-	-		oto91149
orthoMCL	1	0.900	-	-		OOG6_101649
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R947
SonicParanoid	1	1.000	-	-		X2103
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.720