DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and Fbxw7

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001171244.1 Gene:Fbxw7 / 50754 MGIID:1354695 Length:710 Species:Mus musculus


Alignment Length:783 Identity:436/783 - (55%)
Similarity:506/783 - (64%) Gaps:112/783 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 LGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANP 631
            :|..:..|..|....|.:|...:.......:...|..|..|.:|.        .|.....|||||
Mouse     8 VGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEH--------TARNGELVGANP 64

  Fly   632 ---------TASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDL 687
                     ...|.:..|..       :.|:|.:.|......|..:.:.|:.    :||....:.
Mouse    65 RPGDQNDTQQGQVEENNNRF-------ISVDEDSSGNQEEQEEDEEHAGEQE----EEEEEEEEE 118

  Fly   688 EEICTCQNGNGSSYGGSNASLSETFDMDAMDPDEPISLSLSSASAGFTEYS-LTNPSS---LMSH 748
            ||:                    ..:.|..||.:.     ||.....|..| :||.||   |.:|
Mouse   119 EEM--------------------DQESDDFDPSDD-----SSREDEHTHNSNVTNCSSVSDLPAH 158

  Fly   749 QRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLG--PTAVLS 811
            |....|          |:.|.....::                 |..|..||.. ||  |..|..
Mouse   159 QLSSPF----------YTKTTKMKRKL-----------------DHGSEVRSFS-LGKKPCKVSD 195

  Fly   812 VTPSSHLT--SSTP----------GSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLAL 864
            .|.::.|.  |:||          |....||...||    .||..||.||..||.||..|:||||
Mouse   196 YTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSV----QPPTGLQEWLKMFQSWSGPEKLLAL 256

  Fly   865 DRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDN 929
            |.|||.|:|:||:|||:|||||||||||||||:||||:|||:|||||||:||||||.||.|.:||
Mouse   257 DELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDN 321

  Fly   930 LLWKEKCRKAQILAEPRSDRP---KRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLK 991
            |||:|||::..|      |.|   ||.:......|.||||:||:|||.|:.|||...::.|||||
Mouse   322 LLWREKCKEEGI------DEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLK 380

  Fly   992 GHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRT 1056
            ||||||||||||.|||||||||||||||||||.|||||||||||||||||||..|||||||||||
Mouse   381 GHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRT 445

  Fly  1057 LKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCV 1121
            ||||:.::|.|:|||.||||||||||||..:||||||||||||||||.|.|||||:||:||||||
Mouse   446 LKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV 510

  Fly  1122 QYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGN 1186
            ||||:.:||||||:|||:|.||.:.|||||||||||||||||||:||||||||||||||||||||
Mouse   511 QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGN 575

  Fly  1187 CKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFV 1251
            |.|||.|||||||||||:.|||||||||||||:|||.||||||||.||:||.|||||||||..||
Mouse   576 CIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFV 640

  Fly  1252 VTSSDDGTVKLWDVKTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDF 1316
            :||||||||||||:|||:||||||.|:|||||||||||||::|||:||||||||||||||:||||
Mouse   641 ITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDF 705

  Fly  1317 DVE 1319
            ||:
Mouse   706 DVD 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689 36/45 (80%)
WD40 <981..1274 CDD:225201 244/292 (84%)
WD40 988..1264 CDD:238121 235/275 (85%)
WD40 repeat 998..1033 CDD:293791 32/34 (94%)
WD40 repeat 1039..1073 CDD:293791 25/33 (76%)
WD40 repeat 1078..1112 CDD:293791 28/33 (85%)
WD40 repeat 1119..1152 CDD:293791 23/32 (72%)
WD40 repeat 1158..1192 CDD:293791 31/33 (94%)
WD40 repeat 1200..1232 CDD:293791 27/31 (87%)
WD40 repeat 1241..1263 CDD:293791 18/21 (86%)
Fbxw7NP_001171244.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..158 38/193 (20%)
F-box-like 284..328 CDD:372399 34/43 (79%)
WD40 377..653 CDD:238121 235/275 (85%)
WD 1 381..421 37/39 (95%)
WD40 repeat 387..422 CDD:293791 32/34 (94%)
WD 2 423..459 27/35 (77%)
WD40 repeat 428..462 CDD:293791 25/33 (76%)
WD 3 462..501 33/38 (87%)
WD40 repeat 467..501 CDD:293791 28/33 (85%)
WD 4 503..539 25/35 (71%)
WD40 repeat 508..541 CDD:293791 23/32 (72%)
WD 5 542..581 36/38 (95%)
WD40 repeat 547..581 CDD:293791 31/33 (94%)
WD 6 583..621 33/37 (89%)
WD40 repeat 589..621 CDD:293791 27/31 (87%)
WD 7 625..662 30/36 (83%)
WD40 repeat 630..652 CDD:293791 18/21 (86%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167834486
Domainoid 1 1.000 101 1.000 Domainoid score I6988
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1561
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002731
OrthoInspector 1 1.000 - - oto94735
orthoMCL 1 0.900 - - OOG6_101649
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R947
SonicParanoid 1 1.000 - - X2103
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.620

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