DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and aamp

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_998103.1	Gene:	aamp / 405874	ZFINID:	ZDB-GENE-040426-2370	Length:	420	Species:	Danio rerio

Alignment Length:	348	Identity:	89/348 - (25%)
Similarity:	142/348 - (40%)	Gaps:	97/348 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   992 GHDDHVITCLQFSGNRIVSGSDD--NTLKVWSAVNGKCLRTLVGHTGGVWSSQMS---------- 1044
            ||.|.|: |:.||.:..::.|.|  ..::|||          |.....|||:::.
Zfish   123 GHKDSVV-CVGFSSDSALAASGDMSGVIRVWS----------VEKREEVWSAEVGDLEWLEWHPC 176

  Fly  1045 GNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHL--HGSKVVSGSRDATLRVWDIEQGSC 1107
            ..::::|..|.::.:|.:.|||| .|.|.......|..:  .|.:.:.|..|.:||:||::||:.
Zfish   177 APVLLAGVADGSVWMWKLPSGAC-RTFQSPGCQTTCGRILPDGKRAIVGYEDGSLRLWDLKQGTA 240

  Fly  1108 LHVLV---GHLAAVRCV--QYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLH 1167
            ::|:.   ||..|:.||  ..:|.|::||:.|...|:......:.|.:....|:       :|
Zfish   241 IYVIKGQDGHRGALTCVSSNQEGALLLSGSVDGQAKLISSSSGKVLCSFSSQTS-------EG-- 296

  Fly  1168 VVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNIL---VSGNADSTVKVWDITTGQCLQ 1229
              |||...|..|..|  |.|                  |:|   .....|.|:.::|:.|    .
Zfish   297 --SGSAQDSNSVESV--GFC------------------NVLPLAAVAYLDGTLAIYDLNT----H 335

  Fly  1230 TLSGPNKHHSAVTCLQF--NSRFVVTSSDDGTVKLWDVKTG--------------DFIRN---LV 1275
            ||....||...|..||:  .|..|.|.|..|.:.|||.::|              ||:.|   .|
Zfish   336 TLRHQCKHEVGVVQLQWEAESAVVCTCSLSGVLSLWDARSGVLVSEFHGHSAEILDFVLNREASV 400

  Fly  1276 ALDSGGSGGVVWRIRANDTKLIC 1298
            |:.:||.         :..|:.|
Zfish   401 AVTAGGD---------HKAKVFC 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689
		WD40	<981..1274	CDD:225201	83/322 (26%)
		WD40	988..1264	CDD:238121	77/295 (26%)
		WD40 repeat	998..1033	CDD:293791	8/36 (22%)
		WD40 repeat	1039..1073	CDD:293791	10/43 (23%)
		WD40 repeat	1078..1112	CDD:293791	11/35 (31%)
		WD40 repeat	1119..1152	CDD:293791	9/34 (26%)
		WD40 repeat	1158..1192	CDD:293791	9/33 (27%)
		WD40 repeat	1200..1232	CDD:293791	7/34 (21%)
		WD40 repeat	1241..1263	CDD:293791	8/23 (35%)
aamp	NP_998103.1	WD40	77..372	CDD:238121	77/295 (26%)
		WD40	<79..416	CDD:225201	89/348 (26%)
		WD40 repeat	85..123	CDD:293791	89/348 (26%)
		WD40 repeat	160..203	CDD:293791	11/43 (26%)
		WD40 repeat	210..245	CDD:293791	11/34 (32%)
		WD40 repeat	254..290	CDD:293791	9/35 (26%)
		WD40 repeat	306..338	CDD:293791	11/55 (20%)
		WD40 repeat	347..371	CDD:293791	8/23 (35%)
		WD40 repeat	389..415	CDD:293791	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000