DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and EFCAB8

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001137439.1 Gene:EFCAB8 / 388795 HGNCID:34532 Length:1288 Species:Homo sapiens


Alignment Length:290 Identity:68/290 - (23%)
Similarity:121/290 - (41%) Gaps:73/290 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1046 NIIISGSTDRTLKVWD-MDSGACVHTLQGHTSTVRCMHL-----HGSKVVSGSRDATLRVWDIEQ 1104
            |.:::|..|..:::|: ..|...|..::||.::|  .|:     :.|.::|.|:|..:||||:..
Human   383 NFLVTGGYDAFIRLWNPFVSKRPVWLMKGHQTSV--THILVDSRNNSILISVSKDKNIRVWDMLD 445

  Fly  1105 GSCLHVLVGHLAAV-RC-------VQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTN----- 1156
            ..||....|...|: .|       .:.|..||.| .|...:...:.|.|..:...:..|:     
Human   446 YICLQSFCGKFFALGNCPITSAYFFEKDNTLICS-TYSIGILKGYLEAQGLIKARKRTTHCSPLC 509

  Fly  1157 -RVYSLQFDGLHVVSGSLDTSIRVWDVETG--NCKHTLMG--HQSLTS-GMELRQNILVSGNADS 1215
             .:||..|.  .||||.|..::.||:|.||  ..:..:.|  |..:|: .::..:..|::|..|.
Human   510 AVLYSKIFK--QVVSGCLRGTVSVWEVVTGRKTMEFAVSGGQHVEMTAMALDESERCLLTGLRDG 572

  Fly  1216 TVKVWDITTGQCLQTLSGP-----------NK------------------------------HHS 1239
            |:|:|:...|:||.|...|           ||                              :|:
Human   573 TMKMWNYNIGKCLLTFPSPEQLEISGIIHMNKVFYVTGWSKRITHFLFHKTKPVLLCYHWQTYHT 637

  Fly  1240 --AVTCLQFNSRFVVTSSDDGTVKLWDVKT 1267
              .::..::.::|:.|||..|.:..|:..|
Human   638 EDILSMAKYRNQFLGTSSYSGDILFWNTGT 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689
WD40 <981..1274 CDD:225201 68/290 (23%)
WD40 988..1264 CDD:238121 66/285 (23%)
WD40 repeat 998..1033 CDD:293791
WD40 repeat 1039..1073 CDD:293791 6/27 (22%)
WD40 repeat 1078..1112 CDD:293791 12/38 (32%)
WD40 repeat 1119..1152 CDD:293791 8/39 (21%)
WD40 repeat 1158..1192 CDD:293791 13/35 (37%)
WD40 repeat 1200..1232 CDD:293791 10/31 (32%)
WD40 repeat 1241..1263 CDD:293791 5/21 (24%)
EFCAB8NP_001137439.1 EF-hand_7 56..117 CDD:316058
WD40 repeat 154..196 CDD:293791
WD40 repeat 202..242 CDD:293791
WD40 repeat 279..319 CDD:293791
WD40 322..592 CDD:330360 57/213 (27%)
WD40 repeat 326..365 CDD:293791
WD40 repeat 373..411 CDD:293791 6/27 (22%)
WD40 repeat 417..484 CDD:293791 19/67 (28%)
WD40 repeat 508..546 CDD:293791 13/39 (33%)
WD40 554..>676 CDD:330360 22/114 (19%)
WD40 repeat 554..589 CDD:293791 11/34 (32%)
WD40 repeat 596..634 CDD:293791 2/37 (5%)
WD40 repeat 640..675 CDD:293791 7/28 (25%)
WD40 815..>982 CDD:225201
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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