DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and Traf7

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	XP_006246044.1	Gene:	Traf7 / 360491	RGDID:	1559653	Length:	670	Species:	Rattus norvegicus

Alignment Length:	868	Identity:	178/868 - (20%)
Similarity:	282/868 - (32%)	Gaps:	291/868 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   424 SSDSKYTYKDLSTTPTSSRKYTNSRLSKSTAKLNLGSSLGASSCSQHRSGSSSTSKSMESSTSCT 488
            :|||..|..:.:..||.|   |.:.::|:..        |.|:..|||...||:|
  Rat    21 ASDSSGTRMETTFGPTFS---TVTTITKAAD--------GTSTYKQHRRTPSSSS---------- 64

  Fly   489 GAARTDVYTNTNSND--YPSLAPTTSGSSTSGGSCQQDQEENVSASVSYSSVGSQTSQESGCSRT 551
                |..|:..:..|  .|...|..|.|:.|..|...:      :|:|..|..|...:|......
  Rat    65 ----TLAYSPRDEEDGMPPINTPRRSDSAISVRSLHSE------SSMSLRSTFSLPEEEEEPEPL 119

  Fly   552 T-AINPTA--ACSTGSACLGDSQASTSASTSSGAGA--SNRCQYATTSTTKAARQVNASAQTQER 611
            . |..|:.  .|....:...|...:|...|.....|  |.:|.......|.....:..:.|..|.
  Rat   120 VFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNAKLTVVVNNIAVAEQIGEL 184

  Fly   612 FLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEGAGGGDGGVVEPGDFSAEE--- 673
            |:...:...|:|.|                                       :||.|..:.
  Rat   185 FIHCRHGCRAAGTG---------------------------------------KPGVFEVDPRGC 210

  Fly   674 PW-----ANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDA---MDPDEPISLSLSSA 730
            |:     |..|.|::| |...: .|.|         |.|......|:.   :...|.|....|..
  Rat   211 PFTIKLSARKDHESSC-DYRPV-RCPN---------NPSCPPLLKMNLEAHLKECEHIKCPHSKY 264

  Fly   731 SAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFA 795
            ...|    :.|..:..:|                                  .:.||.....:|.
  Rat   265 GCTF----IGNQDTYETH----------------------------------LETCRFEGLKEFL 291

  Fly   796 STPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQF-QRWSHVE 859
            .......|           ..|:               ::..:|.....|:..|.:. ::...:|
  Rat   292 QQTDDRFH-----------EMHV---------------ALAQKDQEIAFLRSMLGKLSEKIDQLE 330

  Fly   860 RLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELA-------LFVLSYLEPKDLLRAAQ 917
            :.|.|.  .|..|.:|.:....::|  |:|| .|:|..||:       :.:|...:|:.:.
  Rat   331 KSLELK--FDVLDENQSKLSEDLME--FRRD-ASMLNDELSHINARLNMGILGSYDPQQIF---- 386

  Fly   918 TCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPWKAAYMRQHIIEMNWRSR 982
                             ||:...:              |:..|:                 |
  Rat   387 -----------------KCKGTFV--------------GHQGPV-----------------W--- 400

  Fly   983 PVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVW-SAVNGKCLRTLVGHTGGVWSSQMSGN 1046
                           ..|:...|:.:.|||.|.|:||| :....||.:||.||.|.|.:..:.|.
  Rat   401 ---------------CLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGC 450

  Fly  1047 IIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDA---------------- 1095
            .:.|||.|.|:.|||:.:...|:|::.|.:.|..:....:.:.|||..|
  Rat   451 KLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKE 515

  Fly  1096 ------------------------TLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYM 1136
                                    |:::|||....|:|||.....:|..:......||.|.|:.:
  Rat   516 LTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENL 580

  Fly  1137 VKIWHPERQECLHTLQGHTNRVYSLQF----DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSL 1197
            :.:|..|.:|.:.||.||...||:|..    |...|.|.|.|.|:|||.::...|..||:.||..
  Rat   581 IHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGS 645

  Fly  1198 TSGMELRQNILVSGNADSTVKVW 1220
            .:.:.:.:..|.||..|||||||
  Rat   646 VTALAVSRGRLFSGAVDSTVKVW 668

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	8/52 (15%)
		WD40	<981..1274	CDD:225201	82/285 (29%)
		WD40	988..1264	CDD:238121	82/278 (29%)
		WD40 repeat	998..1033	CDD:293791	14/35 (40%)
		WD40 repeat	1039..1073	CDD:293791	11/33 (33%)
		WD40 repeat	1078..1112	CDD:293791	12/73 (16%)
		WD40 repeat	1119..1152	CDD:293791	8/32 (25%)
		WD40 repeat	1158..1192	CDD:293791	14/37 (38%)
		WD40 repeat	1200..1232	CDD:293791	10/21 (48%)
		WD40 repeat	1241..1263	CDD:293791
Traf7	XP_006246044.1	mRING-HC-C3HC3D_TRAF7	129..165	CDD:319558	7/35 (20%)
		Sina	207..>281	CDD:418524	17/122 (14%)
		DD_cGKI	282..322	CDD:418404	8/65 (12%)
		PRK03918	283..>373	CDD:235175	21/120 (18%)
		WD40	388..668	CDD:238121	84/328 (26%)
		WD40 repeat	443..477	CDD:293791	11/33 (33%)
		WD40 repeat	482..517	CDD:293791	5/34 (15%)
		WD40 repeat	527..556	CDD:293791	7/28 (25%)
		WD40 repeat	562..596	CDD:293791	9/33 (27%)
		WD40 repeat	604..639	CDD:293791	11/34 (32%)
		WD40 repeat	646..668	CDD:293791	8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810