DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and caf4

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_001342939.1	Gene:	caf4 / 3361526	PomBaseID:	SPAC664.15	Length:	651	Species:	Schizosaccharomyces pombe

Alignment Length:	676	Identity:	143/676 - (21%)
Similarity:	247/676 - (36%)	Gaps:	197/676 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   712 FDMDAMDPD-EPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEV 775
            ||...:.|. .||||.:...|..|..:.|:          |.:|||..|...|...|...:..:
pombe    47 FDSSPVTPQRNPISLFVRGLSHPFLRHRLS----------KSQFNEWFLSHNGVDPVQAQTLPD- 100

  Fly   776 GGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVLSVTPSSH-------LTSSTPGSALGRRTPR 833
                         .:.:|......:|..|  ....|||...|       :|||....  |::...
pombe   101 -------------PLLFDIPDHQETSYSL--LEGYSVTAHDHSDTSPLPITSSNQKE--GKKNVS 148

  Fly   834 SV------PSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIE-PQFQRDF 891
            |:      .|.:..|..|||                 ::|:..|:..:::.::...| .|...:.
pombe   149 SIDVSMVSDSSEFKPDSLQH-----------------EKLVKKCNQLRLQKLINSSELAQIDLEL 196

  Fly   892 ISLLP-RELALFVLSYLEPKDLLRAAQTCRSWRFLCD---------------------------- 927
            ..|.. |...|..||.:|.::|...::.....:.:.|
pombe   197 SKLYSRRRQVLERLSKIEEQNLKYTSKLASVEKLMLDSDAQDLYSSYSHDLIPSQIEAGKNGANP 261

  Fly   928 -----------DNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPW--------KAAYMRQH 973
                       |||       .|:.:: ||:.||....:     :.|.:        ||....:.
pombe   262 DVFDDTHDKYTDNL-------SARAIS-PRAPRPSTASE-----VVSDYFEQNSAFSKAPENTES 313

  Fly   974 IIEMNWRSRPVRKPKVLKGHDDHVITCLQFSG--NRIVSGSDDNTLKVWSAVNGKCLRTLVGHTG 1036
            .:..|:....:  .|..:.|.:: ||.|.||.  ..:.:.|.|.|:|||.......|.:|.||:.
pombe   314 SVNQNYIVGNL--VKQFQAHSEY-ITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSD 375

  Fly  1037 GVWSSQMSGNIIISGSTDRTLKVWDMDSGA---------------------CVHTLQGHTSTVRC 1080
            .|....:..:.|.:||.|.|:::|::|:..                     ..:.|..||:.|..
pombe   376 YVSCLAIQDSFIATGSMDTTVRLWNLDNDVLHKDNPVEESLNSPPDQPVDNATNVLTSHTAPVTA 440

  Fly  1081 MHLHGSKV-VSGSRDATLRVWDIEQGSCL----------------HVLVG-------HLAAVRCV 1121
            :.|....| ::|:.|.|:|.|||..|.|:                .:||.       .:.|:.|:
pombe   441 LALSSDDVLITGADDKTVRQWDIVTGRCIQTLDFVWAETHDTSTSQILVSDTYKQEPFIRALDCL 505

  Fly  1122 QYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGN 1186
            .   ..:.||..|.:::||.......:.:..|||..:.|||||..|:.|||.|.|:|:||:.:|:
pombe   506 D---AAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQFDSNHLYSGSYDNSVRIWDLRSGS 567

  Fly  1187 CKHTLMGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPN--------------KH 1237
            ..:.:...:.:.| :.|.|..|...:.:..|:::|        |:|..|              :.
pombe   568 PINIIPMEKKVNS-LRLYQGRLAVASDEPNVRIFD--------TVSNRNWICSIPSHSDSIAAEP 623

  Fly  1238 HSAVTCLQFNSRFVVTSSDDGTVKLW 1263
            :|..|.:|:..||:|....||:|.::
pombe   624 NSVPTSVQYKDRFLVDGKSDGSVSVF 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	11/85 (13%)
		WD40	<981..1274	CDD:225201	85/344 (25%)
		WD40	988..1264	CDD:238121	85/337 (25%)
		WD40 repeat	998..1033	CDD:293791	13/36 (36%)
		WD40 repeat	1039..1073	CDD:293791	8/54 (15%)
		WD40 repeat	1078..1112	CDD:293791	12/50 (24%)
		WD40 repeat	1119..1152	CDD:293791	6/32 (19%)
		WD40 repeat	1158..1192	CDD:293791	15/33 (45%)
		WD40 repeat	1200..1232	CDD:293791	6/31 (19%)
		WD40 repeat	1241..1263	CDD:293791	8/21 (38%)
caf4	NP_001342939.1	WD40	324..650	CDD:238121	85/341 (25%)
		WD40 repeat	336..372	CDD:293791	12/35 (34%)
		WD40 repeat	377..431	CDD:293791	8/53 (15%)
		WD40 repeat	439..473	CDD:293791	11/33 (33%)
		WD40 repeat	484..533	CDD:293791	9/51 (18%)
		WD40 repeat	539..573	CDD:293791	15/33 (45%)
		WD40 repeat	578..600	CDD:293791	5/22 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910