DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and Fbxw8

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001100615.2 Gene:Fbxw8 / 304522 RGDID:1306032 Length:596 Species:Rattus norvegicus


Alignment Length:536 Identity:113/536 - (21%)
Similarity:188/536 - (35%) Gaps:192/536 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   823 PGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQ-----VRHMMKV 882
            |....||...:.|.||...||                     ||  |..:|..     :|.:.::
  Rat    66 PAPRPGRTDRKDVSSRSRSPP---------------------DR--DAAEPEPLVDQLIRDLNEM 107

  Fly   883 IEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRS 947
            .:..|   |...||.|||:.:..||..::|...||..::|:.:.:|.:||...||          
  Rat   108 DDVPF---FDVHLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCR---------- 159

  Fly   948 DRPKRGRDGNMPPIA----SPWK----AAYMRQHIIEMNWRSRPVRKPKVLKG------HDDHVI 998
                  ::|::|...    :.||    ....|:|.:..||::|        ||      |....:
  Rat   160 ------QEGHLPHSRFSDYTCWKLILQECLAREHKLRANWKNR--------KGAVSELEHVPDAV 210

  Fly   999 TCLQFSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDM- 1062
            .|                             .:..|.|          ::|:|.|...::|||. 
  Rat   211 LC-----------------------------DVRSHDG----------VVIAGYTSGEVRVWDTR 236

  Fly  1063 ----------------DSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVL 1111
                            |.|     :|.:.|.||   ::.|..|:...|..|.|||:..|......
  Rat   237 TWDYVAPFLESESEEEDPG-----MQPYVSFVR---INSSLAVAAYEDGILNVWDLRTGRFPIFR 293

  Fly  1112 VGHLAAVRCV---QYDGKLIVSGAYDYMVKI------WHP----ERQECLHTLQ--GHTNR---- 1157
            ..|.|.::.:   |....:..:.|:|.::..      ||.    |.|:.:..|:  .:|.|    
  Rat   294 FEHDARIQALALSQEKPVVATASAFDVVMLYPNEEGNWHVASEFEVQKLVDYLEIVPNTGRYPVA 358

  Fly  1158 -------VYSLQFDG----LHVVSGS----LDTS-------------------IRVWDVETGNCK 1188
                   ||.|:.:.    ||.|.|.    ||.|                   |.|:.:|...|.
  Rat   359 IATAGDLVYLLKAEDSARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCL 423

  Fly  1189 HTL---MGHQSLTSGMELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRF 1250
            ..|   :|..:..:..:...|::||||.|..|::.|:.|.:...:||.   |...|:.:|.:...
  Rat   424 SKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRLHDLRTDKIALSLSA---HQLGVSAVQMDDWK 485

  Fly  1251 VVTSSDDGTVKLWDVK 1266
            :|:..::|.|.:||.:
  Rat   486 IVSGGEEGLVSVWDYR 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689 15/45 (33%)
WD40 <981..1274 CDD:225201 74/365 (20%)
WD40 988..1264 CDD:238121 71/354 (20%)
WD40 repeat 998..1033 CDD:293791 1/34 (3%)
WD40 repeat 1039..1073 CDD:293791 8/50 (16%)
WD40 repeat 1078..1112 CDD:293791 10/33 (30%)
WD40 repeat 1119..1152 CDD:293791 7/45 (16%)
WD40 repeat 1158..1192 CDD:293791 15/63 (24%)
WD40 repeat 1200..1232 CDD:293791 9/31 (29%)
WD40 repeat 1241..1263 CDD:293791 5/21 (24%)
Fbxw8NP_001100615.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 21..95 12/51 (24%)
F-box-like 116..158 CDD:403981 14/41 (34%)
WD40 186..568 CDD:225201 77/374 (21%)
WD 1 195..243 13/94 (14%)
WD 2 251..292 14/48 (29%)
WD40 repeat 256..295 CDD:293791 12/41 (29%)
WD 3 295..334 7/38 (18%)
WD40 repeat 300..347 CDD:293791 7/46 (15%)
WD40 repeat 355..418 CDD:293791 12/62 (19%)
WD40 repeat 421..470 CDD:293791 12/48 (25%)
WD 4 428..468 10/39 (26%)
WD 5 471..508 8/34 (24%)
WD40 repeat 476..500 CDD:293791 6/23 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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