DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and Fbxw2

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:XP_006498180.1 Gene:Fbxw2 / 30050 MGIID:1353435 Length:491 Species:Mus musculus


Alignment Length:464 Identity:118/464 - (25%)
Similarity:189/464 - (40%) Gaps:120/464 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   844 ELQHWL----AQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVL 904
            :.:.||    ..|...:.:::...||.||......|:||:...:|...:|||:.|||.||:.::|
Mouse    42 DFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLL 106

  Fly   905 SYLEPKDLLRAAQTCRSWRFL---CDDNLLWKEKCRKA--QILAEPRSDRPKRGRDGNMPPIASP 964
            .:|:|:.||......:.|..:   |.:  :|:..|:..  ||             |.::.. :..
Mouse   107 KWLDPQTLLTCCLVSKQWNKVISACTE--VWQTACKNLGWQI-------------DDSVQD-SLH 155

  Fly   965 WKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLR 1029
            ||..|::. |:.|          |.|:.|:....:                              
Mouse   156 WKKVYLKA-ILRM----------KQLEDHEAFETS------------------------------ 179

  Fly  1030 TLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRD 1094
            :|:||:..|::......::.:||.|.:.|:||:.:|.||:.:|.||..  .:.....|:|:||.|
Mouse   180 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQKLVTGSFD 242

  Fly  1095 ATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKL--IVSGAYDYMVKIWHPERQECLHTLQGHTNR 1157
            .|:..|:...|:......||..||..|.|..:|  :|||:.|:.||:|......||:||.|||..
Mouse   243 NTVACWEWSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEW 307

  Fly  1158 VYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADS-TVKVWD 1221
            |..                     |....||...:.|..       ...||:|  ||. .:|:|.
Mouse   308 VTK---------------------VVLQKCKVKSLLHSP-------GDYILLS--ADKYEIKIWP 342

  Fly  1222 I---TTGQCLQTLSGPNKHHSAVTCLQ----FNSRFVVTSSDDGTVKLWDVKTGDFIR------- 1272
            |   ...:||:|||   .......|||    |:.:::|.||..|..: ||..:.|.:|       
Mouse   343 IGREINCKCLKTLS---VSEDRSICLQPRLHFDGKYIVCSSALGLYQ-WDFASYDILRVIKTPEV 403

  Fly  1273 -NLVALDSG 1280
             ||..|..|
Mouse   404 ANLALLGFG 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689 14/48 (29%)
WD40 <981..1274 CDD:225201 78/310 (25%)
WD40 988..1264 CDD:238121 74/285 (26%)
WD40 repeat 998..1033 CDD:293791 1/34 (3%)
WD40 repeat 1039..1073 CDD:293791 9/33 (27%)
WD40 repeat 1078..1112 CDD:293791 8/33 (24%)
WD40 repeat 1119..1152 CDD:293791 13/34 (38%)
WD40 repeat 1158..1192 CDD:293791 4/33 (12%)
WD40 repeat 1200..1232 CDD:293791 11/35 (31%)
WD40 repeat 1241..1263 CDD:293791 8/25 (32%)
Fbxw2XP_006498180.1 FBOX 97..131 CDD:197608 10/33 (30%)
WD40 177..484 CDD:392136 79/302 (26%)
WD40 repeat 188..222 CDD:293791 10/33 (30%)
WD40 repeat 225..260 CDD:293791 9/36 (25%)
WD40 repeat 266..302 CDD:293791 14/35 (40%)
WD40 repeat 318..356 CDD:293791 12/46 (26%)
WD40 repeat 364..399 CDD:293791 12/35 (34%)
WD40 repeat 414..454 CDD:293791
WD40 repeat 460..482 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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