DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and Fbxw2

DIOPT Version :10

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001393196.1 Gene:Fbxw2 / 30050 MGIID:1353435 Length:491 Species:Mus musculus


Alignment Length:464 Identity:118/464 - (25%)
Similarity:189/464 - (40%) Gaps:120/464 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   844 ELQHWL----AQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVL 904
            :.:.||    ..|...:.:::...||.||......|:||:...:|...:|||:.|||.||:.::|
Mouse    42 DFETWLDNISVTFLSLTDLQKNETLDHLISLSGAVQLRHLSNNLETLLKRDFLKLLPLELSFYLL 106

  Fly   905 SYLEPKDLLRAAQTCRSWRFL---CDDNLLWKEKCRKA--QILAEPRSDRPKRGRDGNMPPIASP 964
            .:|:|:.||......:.|..:   |.:  :|:..|:..  ||             |.::.. :..
Mouse   107 KWLDPQTLLTCCLVSKQWNKVISACTE--VWQTACKNLGWQI-------------DDSVQD-SLH 155

  Fly   965 WKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSAVNGKCLR 1029
            ||..|::. |:.|          |.|:.|:....:                              
Mouse   156 WKKVYLKA-ILRM----------KQLEDHEAFETS------------------------------ 179

  Fly  1030 TLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRD 1094
            :|:||:..|::......::.:||.|.:.|:||:.:|.||:.:|.||..  .:.....|:|:||.|
Mouse   180 SLIGHSARVYALYYKDGLLCTGSDDLSAKLWDVSTGQCVYGIQTHTCA--AVKFDEQKLVTGSFD 242

  Fly  1095 ATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKL--IVSGAYDYMVKIWHPERQECLHTLQGHTNR 1157
            .|:..|:...|:......||..||..|.|..:|  :|||:.|:.||:|......||:||.|||..
Mouse   243 NTVACWEWSSGARTQHFRGHTGAVFSVDYSDELDILVSGSADFAVKVWALSAGTCLNTLTGHTEW 307

  Fly  1158 VYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNADS-TVKVWD 1221
            |..                     |....||...:.|..       ...||:|  ||. .:|:|.
Mouse   308 VTK---------------------VVLQKCKVKSLLHSP-------GDYILLS--ADKYEIKIWP 342

  Fly  1222 I---TTGQCLQTLSGPNKHHSAVTCLQ----FNSRFVVTSSDDGTVKLWDVKTGDFIR------- 1272
            |   ...:||:|||   .......|||    |:.:::|.||..|..: ||..:.|.:|       
Mouse   343 IGREINCKCLKTLS---VSEDRSICLQPRLHFDGKYIVCSSALGLYQ-WDFASYDILRVIKTPEV 403

  Fly  1273 -NLVALDSG 1280
             ||..|..|
Mouse   404 ANLALLGFG 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box_FBXW7 875..933 CDD:438905 19/60 (32%)
WD40 <979..1267 CDD:441893 76/297 (26%)
WD40 repeat 998..1033 CDD:293791 1/34 (3%)
WD40 repeat 1039..1073 CDD:293791 9/33 (27%)
WD40 repeat 1078..1112 CDD:293791 8/33 (24%)
WD40 repeat 1119..1152 CDD:293791 13/34 (38%)
WD40 repeat 1158..1192 CDD:293791 4/33 (12%)
WD40 repeat 1200..1232 CDD:293791 11/35 (31%)
WD40 repeat 1241..1263 CDD:293791 8/25 (32%)
Fbxw2NP_001393196.1 F-box_FBXW2 92..131 CDD:438903 13/38 (34%)
WD40 177..484 CDD:475233 79/302 (26%)
WD40 repeat 188..222 CDD:293791 10/33 (30%)
WD40 repeat 225..260 CDD:293791 9/36 (25%)
WD40 repeat 266..302 CDD:293791 14/35 (40%)
WD40 repeat 318..356 CDD:293791 12/46 (26%)
WD40 repeat 364..399 CDD:293791 12/35 (34%)
WD40 repeat 414..454 CDD:293791
WD40 repeat 460..482 CDD:293791
Blue background indicates that the domain is not in the aligned region.

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