DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and pop1

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_001342944.1	Gene:	pop1 / 2540511	PomBaseID:	SPBC1718.01	Length:	775	Species:	Schizosaccharomyces pombe

Alignment Length:	862	Identity:	207/862 - (24%)
Similarity:	337/862 - (39%)	Gaps:	246/862 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 EENVSASVSYSSVGSQTSQESGCSRTTAINPTAACSTGSACLGDSQASTSASTSSGAGASNRCQY 590
            ||....|:.:.|.|||.|.               ..|.:.||.|.:...:.         ....|
pombe    62 EELSRVSLQFDSKGSQQSM---------------IFTNNRCLSDKENLENL---------QNLLY 102

  Fly   591 ATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANPTASVRQRRNGSSDVVHLEVVVEEG 655
            ......:........::.:|:.|.|.|       .|:.:|..|:.|...|..||
pombe   103 LHCDLNRPHLSCELPSEHREKCLKRRN-------SSLSSNLHANKRFLFNSQSD----------- 149

  Fly   656 AGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEICTCQNGNGSSYGGSNASLSETFDMDAMDPD 720
              |.......|     ...::|....||| |.:|:.:                ..||.:||  |:
pombe   150 --GNKKNETFP-----STNYSNVFYPNNC-DSKEVAS----------------ETTFSLDA--PN 188

  Fly   721 EPISLSLSSASAGFTEYSLTNPSSLMSHQRKRKFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDN 785
            ..::            ||..:|:.|.:..:.|:          .:....|||..         ::
pombe   189 NSVN------------YSYFSPNLLGNDSKTRQ----------SFPPHSSSSSH---------NS 222

  Fly   786 CRKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLA 850
            ..:.:.|||:|.       .|    |:.||:||:                 |:.|...:|...::
pombe   223 LHEPVIYDFSSE-------NP----SIHPSNHLS-----------------SQKNAVLKLAQLIS 259

  Fly   851 QFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRA 915
            .|::.....|...|..|:..|....|:::.|::.|.||::|::..|.|:...||::|:...|...
pombe   260 SFEKLPESVRQYLLFHLLSRCGKHAVQNIHKILLPIFQKNFLTGFPAEITNLVLTHLDAPSLCAV 324

  Fly   916 AQTCRSWRFLCDDN-LLWKE------------------KCRKAQILAEPRSDRPKRGRDGNMPPI 961
            :|....|..|...| .|||.                  .|.:..:.|
pombe   325 SQVSHHWYKLVSSNEELWKSLFLKDGFFWDSIDSKIRTMCLEQSLSA------------------ 371

  Fly   962 ASPWKAAYMRQHIIEMNWRSRPVRKPKVLKG-----HDDHVITCLQFSGNRIVSGSDDNTLKVWS 1021
            .:..|..|.|    ..|.|.|.:..|:.:|.     |...:||.|||..::|:..:....:.::.
pombe   372 CAIMKRVYFR----HFNLRERWLHAPEKIKRCSFPIHGVRLITKLQFDDDKIIVSTCSPRINIYD 432

  Fly  1022 AVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHL-HG 1085
            ...|..:|:|..|.|.||:.:..|:.:::||||||::|||:.:|.|.....|||||:||:.: .|
pombe   433 TKTGVLIRSLEEHEGDVWTFEYVGDTLVTGSTDRTVRVWDLRTGECKQVFYGHTSTIRCIKIVQG 497

  Fly  1086 SK-------------------------VVSGSRDATLRVWDIEQGSCL----------------- 1108
            ::                         ::|.|||.|:|:|.:   .||
pombe   498 NQSTTDTDDVEKENRPASNDANSMPPYIISSSRDCTIRLWSL---PCLDDPPFVNVNENPDQNND 559

  Fly  1109 -----------HVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQ 1162
                       ..|.||..:||.|...|.||||.:||..:::|......|||.|:||..||||:.
pombe   560 FTSATTNPFYIRTLRGHTDSVREVACLGDLIVSASYDGTLRVWKASTGVCLHVLRGHVGRVYSVT 624

  Fly  1163 FD--GLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVSGNA--DSTVKVWDIT 1223
            .:  ....:|...|..||:|::|:|....||.||.:|.|.:...||||||.:|  |::::|||:.
pombe   625 INPSRQQCISAGTDAKIRIWNLESGELLQTLHGHSNLVSQVTFNQNILVSASAPPDTSLRVWDLN 689

  Fly  1224 TGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVKTGDFIRNLVA-LDSGGSGGVVW 1287
            ||.|...|..|..|    ...|.:...||:.| ..|::|||:::|..:|:|:. ||      ::|
pombe   690 TGSCRDILKCPLGH----IFFQHDESKVVSGS-HSTLQLWDIRSGKLVRDLLTDLD------IIW 743

  Fly  1288 RIRANDTKLICAVGSRN 1304
            ::..|:...:.||...|
pombe   744 QVAYNENVCVAAVLRNN 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	14/64 (22%)
		WD40	<981..1274	CDD:225201	110/355 (31%)
		WD40	988..1264	CDD:238121	104/338 (31%)
		WD40 repeat	998..1033	CDD:293791	9/34 (26%)
		WD40 repeat	1039..1073	CDD:293791	13/33 (39%)
		WD40 repeat	1078..1112	CDD:293791	12/87 (14%)
		WD40 repeat	1119..1152	CDD:293791	13/32 (41%)
		WD40 repeat	1158..1192	CDD:293791	11/35 (31%)
		WD40 repeat	1200..1232	CDD:293791	14/33 (42%)
		WD40 repeat	1241..1263	CDD:293791	5/21 (24%)
pop1	NP_001342944.1	F-box-like	305..346	CDD:315592	13/40 (33%)
		WD40	409..725	CDD:238121	102/323 (32%)
		WD40 repeat	409..444	CDD:293791	9/34 (26%)
		WD40 repeat	450..484	CDD:293791	13/33 (39%)
		WD40 repeat	489..574	CDD:293791	12/87 (14%)
		WD40 repeat	582..614	CDD:293791	12/31 (39%)
		WD40 repeat	620..656	CDD:293791	11/35 (31%)
		WD40 repeat	662..706	CDD:293791	18/47 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47372
orthoMCL	1	0.900	-	-		OOG6_101649
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710