DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and Fbxw8

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_766309.2 Gene:Fbxw8 / 231672 MGIID:1923041 Length:598 Species:Mus musculus


Alignment Length:585 Identity:119/585 - (20%)
Similarity:196/585 - (33%) Gaps:212/585 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   787 RKRIAYDFASTPRSSQHLGPTAVLSVTPSSHLTSSTPGSALGRRTP------------------R 833
            |:|:......:||.     |.|.....|:|.......|...|...|                  |
Mouse    26 RRRLEAGERRSPRR-----PEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSR 85

  Fly   834 SVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRE 898
            |.|.||...||                     .|:|..    :|.:.::.:..|   |...||.|
Mouse    86 SPPDRDATEPE---------------------PLVDQL----IRDLNELDDVPF---FDVRLPYE 122

  Fly   899 LALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIA- 962
            ||:.:..||..::|...||..::|:.:.:|.:||...||                ::|::|... 
Mouse   123 LAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCR----------------QEGHLPHSRF 171

  Fly   963 ---SPWK----AAYMRQHIIEMNWRSRPVRKPKVLKG------HDDHVITCLQFSGNRIVSGSDD 1014
               :.||    ....::|.:..||::|        ||      |....:.|              
Mouse   172 SDYTCWKLILQECLAKEHTLRANWKNR--------KGAVSELEHVPDAVLC-------------- 214

  Fly  1015 NTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDM----------------- 1062
                           .:..|.|          ::|:|.|...::|||.                 
Mouse   215 ---------------DVRSHDG----------VVIAGYTSGDVRVWDTRTWDYVAPFLESESEEE 254

  Fly  1063 DSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQY-DGK 1126
            |.|     :|.:.|.||   ::.|..|:...|..|.:||:..|........|.|.::.:.. ..|
Mouse   255 DPG-----MQPYVSFVR---INSSLAVAAYEDGILNIWDLRTGRFPIFRFEHDARIQALALSQEK 311

  Fly  1127 LIVSGAYDYMVKIWHPERQECLHT--------------LQGHTNR-----------VYSLQFDG- 1165
            .||:.|..:.|.:.:|..:...|.              :..:|.|           ||.|:.|. 
Mouse   312 PIVATASAFDVVMLYPNEEGHWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDS 376

  Fly  1166 ---LHVVSGS----LDTS-------------------IRVWDVETGNCKHTL---MGHQSLTSGM 1201
               ||.|.|.    ||.|                   |.|:.:|...|...|   :|..:..:..
Mouse   377 ARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIR 441

  Fly  1202 ELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDVK 1266
            :...|::||||.|..|::.|:.:.:...:||.   |...|:.:|.:...||:..::|.|.:||.:
Mouse   442 DSPPNLMVSGNMDRRVRIHDLRSDKIALSLSA---HQLGVSAVQMDDWKVVSGGEEGLVSVWDYR 503

  Fly  1267  1266
            Mouse   504  503

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689 15/45 (33%)
WD40 <981..1274 CDD:225201 73/365 (20%)
WD40 988..1264 CDD:238121 70/354 (20%)
WD40 repeat 998..1033 CDD:293791 1/34 (3%)
WD40 repeat 1039..1073 CDD:293791 8/50 (16%)
WD40 repeat 1078..1112 CDD:293791 9/33 (27%)
WD40 repeat 1119..1152 CDD:293791 7/47 (15%)
WD40 repeat 1158..1192 CDD:293791 16/63 (25%)
WD40 repeat 1200..1232 CDD:293791 8/31 (26%)
WD40 repeat 1241..1263 CDD:293791 6/21 (29%)
Fbxw8NP_766309.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 20..97 18/96 (19%)
F-box-like 118..162 CDD:289689 16/59 (27%)
WD 1 197..245 13/94 (14%)
WD40 209..501 CDD:295369 67/341 (20%)
WD40 repeat 213..252 CDD:293791 9/77 (12%)
WD 2 253..294 13/48 (27%)
WD40 repeat 262..297 CDD:293791 10/37 (27%)
WD40 263..>588 CDD:225201 57/247 (23%)
WD 3 297..336 9/38 (24%)
WD 4 430..470 9/39 (23%)
WD40 repeat 436..472 CDD:293791 8/35 (23%)
WD 5 473..510 9/34 (26%)
WD40 repeat 478..510 CDD:293791 8/26 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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