DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and Traf7

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001165584.1 Gene:Traf7 / 224619 MGIID:3042141 Length:669 Species:Mus musculus


Alignment Length:275 Identity:85/275 - (30%)
Similarity:125/275 - (45%) Gaps:46/275 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   992 GHDDHV-ITCLQFSGNRIVSGSDDNTLKVW-SAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTD 1054
            ||...| ..|:...|:.:.|||.|.|:||| :....||.:||.||.|.|.:..:.|..:.|||.|
Mouse   393 GHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSAD 457

  Fly  1055 RTLKVWDMDSGACVHTLQGHTSTVRCMHLHGSKVVSGSRDA------------------------ 1095
            .|:.|||:.:...|:|::.|.:.|..:....:.:.|||..|                        
Mouse   458 CTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNMLFSGSLKAIKVWDIVGTELKLKKELTGLNHWV 522

  Fly  1096 ----------------TLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPER 1144
                            |:::|||....|:|||.....:|..:......||.|.|:.::.:|..|.
Mouse   523 RALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIES 587

  Fly  1145 QECLHTLQGHTNRVYSLQF----DGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQ 1205
            :|.:.||.||...||:|..    |...|.|.|.|.|:|||.::...|..||:.||...:.:.:.:
Mouse   588 KEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSR 652

  Fly  1206 NILVSGNADSTVKVW 1220
            ..|.||..|||||||
Mouse   653 GRLFSGAVDSTVKVW 667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689
WD40 <981..1274 CDD:225201 85/275 (31%)
WD40 988..1264 CDD:238121 85/275 (31%)
WD40 repeat 998..1033 CDD:293791 14/35 (40%)
WD40 repeat 1039..1073 CDD:293791 11/33 (33%)
WD40 repeat 1078..1112 CDD:293791 12/73 (16%)
WD40 repeat 1119..1152 CDD:293791 8/32 (25%)
WD40 repeat 1158..1192 CDD:293791 14/37 (38%)
WD40 repeat 1200..1232 CDD:293791 10/21 (48%)
WD40 repeat 1241..1263 CDD:293791
Traf7NP_001165584.1 RING 130..162 CDD:214546
Sina 206..>279 CDD:302762
DD_cGKI 281..321 CDD:213458
WD40 <379..667 CDD:225201 83/273 (30%)
WD40 387..667 CDD:238121 83/273 (30%)
WD40 repeat 442..476 CDD:293791 11/33 (33%)
WD40 repeat 481..516 CDD:293791 5/34 (15%)
WD40 repeat 526..555 CDD:293791 7/28 (25%)
WD40 repeat 561..595 CDD:293791 9/33 (27%)
WD40 repeat 603..638 CDD:293791 11/34 (32%)
WD40 repeat 645..667 CDD:293791 8/21 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0274
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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