DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and mec-15

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_496207.1	Gene:	mec-15 / 174587	WormBaseID:	WBGene00003177	Length:	406	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	74/360 - (20%)
Similarity:	129/360 - (35%)	Gaps:	71/360 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 LPRELALFVLSYLEPKDLL-RAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNM 958
            ||.||...:.:||..:.|: .....||.:..:.:|:..|..:.|..|.:..|..:...
Worm    12 LPSELLCHLFTYLPQRQLITEIPLVCRRFNTILNDDKFWSRRIRTEQKVRLPDCELKH------- 69

  Fly   959 PPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNR---IVSGSDDNTLKVW 1020
             |...|.|:.| ..|.....||:...:......||...|.:.:.|..|.   .:|||.|.|:::|
Worm    70 -PEYEPKKSFY-AMHRQRDRWRAWETQTVITAPGHSATVDSVMLFENNNKQFCLSGSRDRTIRLW 132

  Fly  1021 SAVNGK-----------CLRTLVGHTGGVW--SSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQ 1072
            |..|.:           ..:....|:|.:|  :.:.:.....:.|.|.|:|.|.:.....:..|.
Worm   133 SIENARNGEDTEQNPWTVAKDDTAHSGWIWNMAQESTSTNFYTTSWDSTVKSWHITDNGALQNLN 197

  Fly  1073 GHT--STVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDY 1135
            ...  |..:|:                        ||    .|:...|.|..:..::.|..:..:
Worm   198 SVNVGSAAQCI------------------------SC----SGNENEVVCTTFAKRVAVIDSRTF 234

  Fly  1136 MVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLT-- 1198
            .|...|          :.|...|.:|...|..:.:...|..:.:  |:..|....::...|.|
Worm   235 QVVADH----------KLHKRAVIALAVQGDKIFTSGEDRLMMM--VDRRNFSKPVLFEYSPTAY 287

  Fly  1199 -SGMELRQNILVSGNADSTVKVWDITTGQCLQTLS 1232
             |.:.|:.|.|::..:|..||::|......|||.|
Worm   288 KSCLSLQCNQLLTSTSDGKVKLYDANNFNVLQTYS 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	11/43 (26%)
		WD40	<981..1274	CDD:225201	53/273 (19%)
		WD40	988..1264	CDD:238121	53/266 (20%)
		WD40 repeat	998..1033	CDD:293791	10/48 (21%)
		WD40 repeat	1039..1073	CDD:293791	7/35 (20%)
		WD40 repeat	1078..1112	CDD:293791	3/33 (9%)
		WD40 repeat	1119..1152	CDD:293791	4/32 (13%)
		WD40 repeat	1158..1192	CDD:293791	6/33 (18%)
		WD40 repeat	1200..1232	CDD:293791	10/31 (32%)
		WD40 repeat	1241..1263	CDD:293791
mec-15	NP_496207.1	F-box-like	9..52	CDD:315592	11/39 (28%)
		WD40	88..322	CDD:330360	54/273 (20%)
		WD40 repeat	106..154	CDD:293791	11/47 (23%)
		WD40 repeat	162..197	CDD:293791	6/34 (18%)
		WD40 repeat	204..241	CDD:293791	9/74 (12%)
		WD40 repeat	247..286	CDD:293791	7/40 (18%)
		WD40 repeat	290..310	CDD:293791	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810