DRSC/TRiP Functional Genomics Resources

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Protein Alignment ago and lin-23

DIOPT Version :9

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001300561.1 Gene:lin-23 / 174058 WormBaseID:WBGene00003009 Length:667 Species:Caenorhabditis elegans


Alignment Length:553 Identity:161/553 - (29%)
Similarity:238/553 - (43%) Gaps:115/553 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   800 SSQHLGPT----AVLSVTPSSHLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVER 860
            ||.|...|    |.||:|...|          ....|.|:.........::..|    :||..|:
 Worm     2 SSPHRASTTQQLADLSLTEGEH----------DEGKPLSIDYLQGHEGLIEEVL----KWSEHEQ 52

  Fly   861 LLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFL 925
            |..:|:::......|:..:...|.|..||||||.||..|...:|..:....|....:...|||  
 Worm    53 LDFMDKIVHRLSHYQLGKVDNFIRPMLQRDFISNLPAHLVELILFNVNSDSLKSCEEVSTSWR-- 115

  Fly   926 C-----------------DDNLLW--KEK------------------CRKAQILAEPRSDR---- 949
            |                 .|:|.|  .||                  |.|.......:.|:    
 Worm   116 CALARGQHWKKLIEKNVRSDSLWWGLSEKRQWDKFLNISRDMSVRRICEKFNYDVNIKRDKLDQL 180

  Fly   950 -----------PKRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKV-LKGHDDHVITCLQ 1002
                       ||..||                .|.|:.||:....:..:: .:..:...:.|||
 Worm   181 ILMHVFYSKLYPKIIRD----------------IHNIDNNWKRGNYKMTRINCQSENSKGVYCLQ 229

  Fly  1003 FSGNRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGAC 1067
            :..::||||..|||:|:|...:..|.|.|.||||.|...|....:|||||:|.|::|||:::|.|
 Worm   230 YDDDKIVSGLRDNTIKIWDRKDYSCSRILSGHTGSVLCLQYDNRVIISGSSDATVRVWDVETGEC 294

  Fly  1068 VHTLQGHTSTVRCMHLHGSKVVSGSRDATLRVWDI---EQGSCLHVLVGHLAAVRCVQYDGKLIV 1129
            :.||..|...|..:......:|:.|:|.::.|||:   ...:...|||||.|||..|.:|.:.||
 Worm   295 IKTLIHHCEAVLHLRFANGIMVTCSKDRSIAVWDMVSPRDITIRRVLVGHRAAVNVVDFDDRYIV 359

  Fly  1130 SGAYDYMVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGH 1194
            |.:.|..:|:|..:..|.:.||.||...:..||:.|..|||||.|.:||:||:.:|.|...|.||
 Worm   360 SASGDRTIKVWSMDTLEFVRTLAGHRRGIACLQYRGRLVVSGSSDNTIRLWDIHSGVCLRVLEGH 424

  Fly  1195 QSLTSGMELRQNILVSGNADSTVKVWD---------ITTGQCLQTLSGPNKHHSAVTCLQFNSRF 1250
            :.|...:...:..:|||..|..:||||         :::..||.:|.   :|...|..|||:...
 Worm   425 EELVRCIRFDEKRIVSGAYDGKIKVWDLQAALDPRALSSEICLCSLV---QHTGRVFRLQFDDFQ 486

  Fly  1251 VVTSSDDGTVKLWDVKTGDFIRNLVALDSGGSG 1283
            :|:||.|.|:.:||.           ||:..||
 Worm   487 IVSSSHDDTILIWDF-----------LDAPPSG 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box-like 892..938 CDD:289689 17/82 (21%)
WD40 <981..1274 CDD:225201 106/305 (35%)
WD40 988..1264 CDD:238121 104/288 (36%)
WD40 repeat 998..1033 CDD:293791 15/34 (44%)
WD40 repeat 1039..1073 CDD:293791 15/33 (45%)
WD40 repeat 1078..1112 CDD:293791 8/36 (22%)
WD40 repeat 1119..1152 CDD:293791 10/32 (31%)
WD40 repeat 1158..1192 CDD:293791 15/33 (45%)
WD40 repeat 1200..1232 CDD:293791 10/40 (25%)
WD40 repeat 1241..1263 CDD:293791 9/21 (43%)
lin-23NP_001300561.1 Beta-TrCP_D 41..80 CDD:198096 9/42 (21%)
WD40 168..515 CDD:225201 119/371 (32%)
WD40 222..500 CDD:238121 104/280 (37%)
WD40 repeat 225..260 CDD:293791 15/34 (44%)
WD40 repeat 266..300 CDD:293791 15/33 (45%)
WD40 repeat 305..342 CDD:293791 8/36 (22%)
WD40 repeat 349..382 CDD:293791 10/32 (31%)
WD40 repeat 388..422 CDD:293791 15/33 (45%)
WD40 repeat 428..471 CDD:293791 10/42 (24%)
WD40 repeat 477..499 CDD:293791 9/21 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D150270at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R947
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

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