DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ago and FBXO16

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	NP_758954.1	Gene:	FBXO16 / 157574	HGNCID:	13618	Length:	292	Species:	Homo sapiens

Alignment Length:	181	Identity:	49/181 - (27%)
Similarity:	80/181 - (44%)	Gaps:	27/181 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   845 LQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRHMMKVIE---PQFQRDFISLLPRELALFVLSY 906
            |..|   |.:|:..:|...|..|::.|..||.:...:.::   |....||.:.|||.|:|::.|:
Human    42 LGKW---FDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSLYIFSF 103

  Fly   907 LEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILAEPRSDRPKRGRDGNMPPIASPWKAAYMR 971
            |:|:.|.|.||.|..|:.|.:.:.||..||.:.....             |..|  :|::....:
Human   104 LDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYI-------------NFSP--TPFEQGIWK 153

  Fly   972 QHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLKVWSA 1022
            :|.|:| .:...:.|||. ...|..||..:|.    :.|.|.:......||
Human   154 KHYIQM-VKELHITKPKT-PPKDGFVIADVQL----VTSNSPEEKQSPLSA 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	19/45 (42%)
		WD40	<981..1274	CDD:225201	11/42 (26%)
		WD40	988..1264	CDD:238121	9/35 (26%)
		WD40 repeat	998..1033	CDD:293791	6/25 (24%)
		WD40 repeat	1039..1073	CDD:293791
		WD40 repeat	1078..1112	CDD:293791
		WD40 repeat	1119..1152	CDD:293791
		WD40 repeat	1158..1192	CDD:293791
		WD40 repeat	1200..1232	CDD:293791
		WD40 repeat	1241..1263	CDD:293791
FBXO16	NP_758954.1	F-box-like	92..129	CDD:315592	15/36 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..224		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..292
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0274
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900