Protein Alignment ago and Btrc

DIOPT Version :10

• Sequence 1: NP_523922.1
• Gene: ago / 38516
• FlyBaseID: FBgn0041171
• Length: 1326
• Species: Drosophila melanogaster
• Sequence 2: NP_001347049.1
• Gene: Btrc / 12234
• MGIID: 1338871
• Length: 619
• Species: Mus musculus
• Alignment Length: 453
• Identity: 157/453 - (34%)
• Similarity: 233/453 - (51%)
• Gaps: 52/453 - (11%)

  Fly   852 FQRWSHVERLLALDRLIDHCDPSQVRHMMKVIEPQFQRDFISLLPR----ELALFVLSYLEPKDL 912
            |::||..:::..::.||......|..|:...::|..|||||:.||.    .:|..:||||:.|.|
Mouse   155 FEQWSESDQVEFVEHLISQMCHYQHGHINSYLKPMLQRDFITALPARGLDHIAENILSYLDAKSL 219

  Fly   913 LRAAQTCRSWRFLCDDNLLWKEKCRKA-------QILAEPR-------SDRPKRGRDGNMPPIAS 963
            ..|...|:.|..:..|.:|||:...:.       :.|||.|       .::|.   |.|.|| .|
Mouse   220 CAAELVCKEWYRVTSDGMLWKKLIERMVRTDSLWRGLAERRGWGQYLFKNKPP---DENAPP-NS 280

  Fly   964 PWKAAYMR--QHI--IEMNWR------SRPVRKPKVLKGHDDHVITCLQFSGNRIVSGSDDNTLK 1018
            .::|.|.:  |.|  ||.|||      .|...:.:..||     :.|||:...:||||..|||:|
Mouse   281 FYRALYPKIIQDIETIESNWRCGRHSLQRIHCRSETSKG-----VYCLQYDDQKIVSGLRDNTIK 340

  Fly  1019 VWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHTLQGHTSTVRCMHL 1083
            :|.....:|.|.|.||||.|...|....:||:||:|.|::|||:::|..::||..|...|..:..
Mouse   341 IWDKSTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVNAGEMLNTLIHHCEAVLHLRF 405

  Fly  1084 HGSKVVSGSRDATLRVWDIEQGSCL---HVLVGHLAAVRCVQYDGKLIVSGAYDYMVKIWHPERQ 1145
            :...:|:.|:|.::.|||:...:.:   .|||||.|||..|.:|.|.|||.:.|..:|:|:....
Mouse   406 NNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWNTSTC 470

  Fly  1146 ECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSGMELRQNILVS 1210
            |.:.||.||...:..||:....|||||.|.:||:||:|.|.|...|.||:.|...:......:||
Mouse   471 EFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVS 535

  Fly  1211 GNADSTVKVWDITTG---------QCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWD 1264
            |..|..:||||:...         .||:||.   :|...|..|||:...:|:||.|.|:.:||
Mouse   536 GAYDGKIKVWDLMAALDPRAPAGTLCLRTLV---EHSGRVFRLQFDEFQIVSSSHDDTILIWD 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box_FBXW7	875..933	CDD:438905	22/61 (36%)
		WD40	<979..1267	CDD:441893	111/304 (37%)
		WD40 repeat	998..1033	CDD:293791	15/34 (44%)
		WD40 repeat	1039..1073	CDD:293791	13/33 (39%)
		WD40 repeat	1078..1112	CDD:293791	8/36 (22%)
		WD40 repeat	1119..1152	CDD:293791	11/32 (34%)
		WD40 repeat	1158..1192	CDD:293791	15/33 (45%)
		WD40 repeat	1200..1232	CDD:293791	11/40 (28%)
		WD40 repeat	1241..1263	CDD:293791	9/21 (43%)
Btrc	NP_001347049.1	Beta-TrCP_D	153..191	CDD:463465	8/35 (23%)
		F-box_FBXW1A	189..248	CDD:438953	21/58 (36%)
		WD40	317..595	CDD:238121	106/285 (37%)
		WD40 repeat	320..355	CDD:293791	15/34 (44%)
		WD40 repeat	361..395	CDD:293791	13/33 (39%)
		WD40 repeat	400..437	CDD:293791	8/36 (22%)
		WD40 repeat	444..477	CDD:293791	11/32 (34%)
		WD40 repeat	483..517	CDD:293791	15/33 (45%)
		WD40 repeat	523..566	CDD:293791	11/42 (26%)
		WD40 repeat	572..594	CDD:293791	9/21 (43%)