DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ago and Fbxw7

DIOPT Version :10

Sequence 1:NP_523922.1 Gene:ago / 38516 FlyBaseID:FBgn0041171 Length:1326 Species:Drosophila melanogaster
Sequence 2:NP_001406457.1 Gene:Fbxw7 / 100360914 RGDID:2321145 Length:713 Species:Rattus norvegicus


Alignment Length:769 Identity:434/769 - (56%)
Similarity:513/769 - (66%) Gaps:81/769 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 LGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANP 631
            :|..:..|..|....|.:|.      ....:..|.|....|.|.|.  :.....|.....|||:|
  Rat     8 VGSKRRRTGGSLRGNASSSQ------VDEEQMNRVVEEDPQQQPRH--QEEEHTARNGELVGADP 64

  Fly   632 TASVRQRRNGSSDVVHLE------VVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEI 690
                |......|....:|      |.|:|.:.|......|..:.:.|:     :||....:.||.
  Rat    65 ----RPGAQNDSQQGQVEENNNRFVSVDEDSSGNQEEQEEDEEHAGEQ-----EEEEEEEEEEEE 120

  Fly   691 CTCQNGNGSSYGGSNASLSE---TFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKR 752
            ....:.....:..|:.|..|   |.:.:..:....:.|.::..|:.|  |:.|.       :.||
  Rat   121 EEEMDQESDDFDQSDDSSREDEHTHNSNVTNCTSVVDLPINQLSSPF--YTKTT-------KMKR 176

  Fly   753 KFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVL--SVTPS 815
            |.:.|..:          .|..:|.....||         |:.||         |.::  |.||:
  Rat   177 KLDHGSEV----------RSFSLGKKPCKVS---------DYTST---------TGLVPCSATPT 213

  Fly   816 S--HLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRH 878
            :  .|.::. |....||...||    .||..||.||..||.||..|:|||||.|||.|:|:||:|
  Rat   214 TFGDLRAAN-GQGQQRRRITSV----QPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKH 273

  Fly   879 MMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILA 943
            ||:|||||||||||||||:||||:|||:|||||||:||||||.||.|.:|||||:|||::..|  
  Rat   274 MMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGI-- 336

  Fly   944 EPRSDRP---KRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSG 1005
                |.|   ||.:......|.||||:||:|||.|:.|||...:|.|||||||||||||||||.|
  Rat   337 ----DEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELRSPKVLKGHDDHVITCLQFCG 397

  Fly  1006 NRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHT 1070
            ||||||||||||||||||.|||||||||||||||||||..|||||||||||||||:.::|.|:||
  Rat   398 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHT 462

  Fly  1071 LQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDY 1135
            |.||||||||||||..:||||||||||||||||.|.|||||:||:||||||||||:.:||||||:
  Rat   463 LYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF 527

  Fly  1136 MVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSG 1200
            |||:|.||.:.|||||||||||||||||||:|||||||||||||||||||||.|||.||||||||
  Rat   528 MVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 592

  Fly  1201 MELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDV 1265
            |||:.|||||||||||||:|||.||||||||.||:||.|||||||||..||:||||||||||||:
  Rat   593 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 657

  Fly  1266 KTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVE 1319
            |||:||||||.|:|||||||||||||::|||:||||||||||||||:||||||:
  Rat   658 KTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVD 711

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
agoNP_523922.1 F-box_FBXW7 875..933 CDD:438905 47/57 (82%)
WD40 <979..1267 CDD:441893 241/287 (84%)
WD40 repeat 998..1033 CDD:293791 32/34 (94%)
WD40 repeat 1039..1073 CDD:293791 25/33 (76%)
WD40 repeat 1078..1112 CDD:293791 28/33 (85%)
WD40 repeat 1119..1152 CDD:293791 23/32 (72%)
WD40 repeat 1158..1192 CDD:293791 31/33 (94%)
WD40 repeat 1200..1232 CDD:293791 27/31 (87%)
WD40 repeat 1241..1263 CDD:293791 18/21 (86%)
Fbxw7NP_001406457.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..150 32/158 (20%)
F-box_FBXW7 270..328 CDD:438905 47/57 (82%)
WD40 317..698 CDD:441893 302/386 (78%)
WD 1. /evidence=ECO:0000255 384..424 37/39 (95%)
WD40 repeat 390..425 CDD:293791 32/34 (94%)
WD 2. /evidence=ECO:0000255 426..462 27/35 (77%)
WD40 repeat 431..465 CDD:293791 25/33 (76%)
WD 3. /evidence=ECO:0000255 465..504 33/38 (87%)
WD40 repeat 470..504 CDD:293791 28/33 (85%)
WD 4. /evidence=ECO:0000255 506..542 25/35 (71%)
WD40 repeat 511..544 CDD:293791 23/32 (72%)
WD 5. /evidence=ECO:0000255 545..584 36/38 (95%)
WD40 repeat 550..584 CDD:293791 31/33 (94%)
WD 6. /evidence=ECO:0000255 586..624 33/37 (89%)
WD40 repeat 592..624 CDD:293791 27/31 (87%)
WD 7. /evidence=ECO:0000255 628..665 30/36 (83%)
WD40 repeat 633..655 CDD:293791 18/21 (86%)

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