DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ago and Fbxw7

DIOPT Version :9

Sequence 1:	NP_523922.1	Gene:	ago / 38516	FlyBaseID:	FBgn0041171	Length:	1326	Species:	Drosophila melanogaster
Sequence 2:	XP_038959667.1	Gene:	Fbxw7 / 100360914	RGDID:	2321145	Length:	713	Species:	Rattus norvegicus

Alignment Length:	769	Identity:	434/769 - (56%)
Similarity:	513/769 - (66%)	Gaps:	81/769 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   567 LGDSQASTSASTSSGAGASNRCQYATTSTTKAARQVNASAQTQERFLTRSNPPAASGAGSVGANP 631
            :|..:..|..|....|.:|.      ....:..|.|....|.|.|.  :.....|.....|||:|
  Rat     8 VGSKRRRTGGSLRGNASSSQ------VDEEQMNRVVEEDPQQQPRH--QEEEHTARNGELVGADP 64

  Fly   632 TASVRQRRNGSSDVVHLE------VVVEEGAGGGDGGVVEPGDFSAEEPWANCDEENNCSDLEEI 690
                |......|....:|      |.|:|.:.|......|..:.:.|:     :||....:.||.
  Rat    65 ----RPGAQNDSQQGQVEENNNRFVSVDEDSSGNQEEQEEDEEHAGEQ-----EEEEEEEEEEEE 120

  Fly   691 CTCQNGNGSSYGGSNASLSE---TFDMDAMDPDEPISLSLSSASAGFTEYSLTNPSSLMSHQRKR 752
            ....:.....:..|:.|..|   |.:.:..:....:.|.::..|:.|  |:.|.       :.||
  Rat   121 EEEMDQESDDFDQSDDSSREDEHTHNSNVTNCTSVVDLPINQLSSPF--YTKTT-------KMKR 176

  Fly   753 KFNEGRLLDGGDYSVTISSSGEVGGPGSGVSDNCRKRIAYDFASTPRSSQHLGPTAVL--SVTPS 815
            |.:.|..:          .|..:|.....||         |:.||         |.::  |.||:
  Rat   177 KLDHGSEV----------RSFSLGKKPCKVS---------DYTST---------TGLVPCSATPT 213

  Fly   816 S--HLTSSTPGSALGRRTPRSVPSRDNPPPELQHWLAQFQRWSHVERLLALDRLIDHCDPSQVRH 878
            :  .|.::. |....||...||    .||..||.||..||.||..|:|||||.|||.|:|:||:|
  Rat   214 TFGDLRAAN-GQGQQRRRITSV----QPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKH 273

  Fly   879 MMKVIEPQFQRDFISLLPRELALFVLSYLEPKDLLRAAQTCRSWRFLCDDNLLWKEKCRKAQILA 943
            ||:|||||||||||||||:||||:|||:|||||||:||||||.||.|.:|||||:|||::..|
  Rat   274 MMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGI-- 336

  Fly   944 EPRSDRP---KRGRDGNMPPIASPWKAAYMRQHIIEMNWRSRPVRKPKVLKGHDDHVITCLQFSG 1005
                |.|   ||.:......|.||||:||:|||.|:.|||...:|.|||||||||||||||||.|
  Rat   337 ----DEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELRSPKVLKGHDDHVITCLQFCG 397

  Fly  1006 NRIVSGSDDNTLKVWSAVNGKCLRTLVGHTGGVWSSQMSGNIIISGSTDRTLKVWDMDSGACVHT 1070
            ||||||||||||||||||.|||||||||||||||||||..|||||||||||||||:.::|.|:||
  Rat   398 NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHT 462

  Fly  1071 LQGHTSTVRCMHLHGSKVVSGSRDATLRVWDIEQGSCLHVLVGHLAAVRCVQYDGKLIVSGAYDY 1135
            |.||||||||||||..:||||||||||||||||.|.|||||:||:||||||||||:.:||||||:
  Rat   463 LYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDF 527

  Fly  1136 MVKIWHPERQECLHTLQGHTNRVYSLQFDGLHVVSGSLDTSIRVWDVETGNCKHTLMGHQSLTSG 1200
            |||:|.||.:.|||||||||||||||||||:|||||||||||||||||||||.|||.||||||||
  Rat   528 MVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSG 592

  Fly  1201 MELRQNILVSGNADSTVKVWDITTGQCLQTLSGPNKHHSAVTCLQFNSRFVVTSSDDGTVKLWDV 1265
            |||:.|||||||||||||:|||.||||||||.||:||.|||||||||..||:||||||||||||:
  Rat   593 MELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 657

  Fly  1266 KTGDFIRNLVALDSGGSGGVVWRIRANDTKLICAVGSRNGTEETKLMVLDFDVE 1319
            |||:||||||.|:|||||||||||||::|||:||||||||||||||:||||||:
  Rat   658 KTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVD 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ago	NP_523922.1	F-box-like	892..938	CDD:289689	36/45 (80%)
		WD40	<981..1274	CDD:225201	245/292 (84%)
		WD40	988..1264	CDD:238121	235/275 (85%)
		WD40 repeat	998..1033	CDD:293791	32/34 (94%)
		WD40 repeat	1039..1073	CDD:293791	25/33 (76%)
		WD40 repeat	1078..1112	CDD:293791	28/33 (85%)
		WD40 repeat	1119..1152	CDD:293791	23/32 (72%)
		WD40 repeat	1158..1192	CDD:293791	31/33 (94%)
		WD40 repeat	1200..1232	CDD:293791	27/31 (87%)
		WD40 repeat	1241..1263	CDD:293791	18/21 (86%)
Fbxw7	XP_038959667.1	F-box-like	287..331	CDD:403981	34/43 (79%)
		WD40	380..656	CDD:238121	235/275 (85%)
		WD40 repeat	390..425	CDD:293791	32/34 (94%)
		WD40 repeat	431..465	CDD:293791	25/33 (76%)
		WD40 repeat	470..504	CDD:293791	28/33 (85%)
		WD40 repeat	511..544	CDD:293791	23/32 (72%)
		WD40 repeat	550..584	CDD:293791	31/33 (94%)
		WD40 repeat	592..624	CDD:293791	27/31 (87%)
		WD40 repeat	633..655	CDD:293791	18/21 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338065
Domainoid	1	1.000	101	1.000	Domainoid score	I6797
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	817	1.000	Inparanoid score	I446
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002731
OrthoInspector	1	1.000	-	-		oto98238
orthoMCL	1	0.900	-	-		OOG6_101649
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2103
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790