Protein Alignment pav and KIF20B

DIOPT Version :9

• Sequence 1: NP_477025.1
• Gene: pav / 38515
• FlyBaseID: FBgn0011692
• Length: 887
• Species: Drosophila melanogaster
• Sequence 2: NP_001271188.1
• Gene: KIF20B / 9585
• HGNCID: 7212
• Length: 1820
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 262/1062 - (24%)
• Similarity: 444/1062 - (41%)
• Gaps: 290/1062 - (27%)

  Fly    30 SDKARDPVNVFCRVRPL-QSDADLTS---LRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFK 90
            |.:::|.:.|..|:||. ||:.:|.|   :.:.:|.|:.|.....:|......:..|...::.|.
Human    52 SFESKDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFS 116

  Fly    91 HVFQPDATQQDVY-AAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLF 154
            .||.|..||::.: ..:.|| |::||||::.|:||||:|.||||||..|...:.||:||.|:|||
Human   117 KVFGPATTQKEFFQGCIMQP-VKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLF 180

  Fly   155 RTISDYQAKKFVFKPDKLNGFEILSEE---------DALLERQHEMNQRFAGSGRFAFRHKDSDP 210
            .::.:....|...||.:...:..||.|         .|||.:..|:..           |.|||.
Human   181 DSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTV-----------HNDSDD 234

  Fly   211 EIAS-----------QASVEPIPLLGLDEDN--MYSVFVTYIEIYNNSVYDLL--EDSGIQKTLQ 260
            .:..           :.|::......|:..|  .:||:|::.||||..:|||.  ..|..||
Human   235 TLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQK--- 296

  Fly   261 SKIIR--EDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQ 323
            .|::|  :|...:.|:..:..::|...::|..:.::|.|.:.:..|.||..||||||:|.::::|
Human   297 RKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQ 361

  Fly   324 APTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRE 388
            . .||:...|::      ||:|||.|||||||:.:|:|.|.||||.||||.||:||..|:..|:.
Human   362 I-EDSEMSRVIR------VSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKN 419

  Fly   389 NQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEV- 452
            ::.:...    :.||:|:||:||.|:::|:|:|::.|||.|:.....|||.:.|:||:.:.|:|
Human   420 SEKSKFQ----QHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVC 480

  Fly   453 ---------------------------------QIARAT-------------------------- 458
                                             .:.|||
Human   481 VPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEET 545

  Fly   459 ------PMKQDLGLTPGRRKA-------NKLFKIAVNNLNELGIPEAKD-LEVDVGLVYSLGPDF 509
                  .:.:||..|....||       .||..: :.:|.:..|.|.|: |.::..:...:..:|
Human   546 QNVETKLLDEDLDKTLEENKAFISHEEKRKLLDL-IEDLKKKLINEKKEKLTLEFKIREEVTQEF 609

  Fly   510 PAY----EMDSPEAQIKIRELMHYLEQRIEKRKKLRANLDIKCDS-------------------- 550
            ..|    |.|..|..::.||:   ||:..|:|..:..:|..|||:
Human   610 TQYWAQREADFKETLLQEREI---LEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHN 671

  Fly   551 ---FRQMLMNLDRDNL--------------------------------QLRTELASLKA------ 574
               |..::.:| :||:                                |::.|||..|.
Human   672 YVGFEDIIDSL-QDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTK 735

  Fly   575 --VYKQERDRSAALE------KKVRIHESSIDVLNNTLSKQERQIEEL---------TFKLNEK- 621
              :.|:|.:..:.::      ||:......|..|.|.:.::|..|.|.         |||.|:|
Human   736 EELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKA 800

  Fly   622 --------ENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVK---------LQERM 669
                    ..::..:..|..|..|   ||:..|. |...|.||:..|...|         :.|..
Human   801 DTSSLIINNKLICNETVEVPKDSK---SKICSER-KRVNENELQQDEPPAKKGSIHVSSAITEDQ 861

  Fly   670 RIKDEKLRLVSNILQSEDLPSLPRSQSS--------ENIL-NEKDRGAYTAR-----------TE 714
            : |.|::|  .||.:.||:..|..:...        ||.| |||:..|...:           :|
Human   862 K-KSEEVR--PNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSE 923

  Fly   715 ESSVPATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGT------IMQPYLKNRK 773
            :.::..::........:..|.|....::|::...:....:.:|.:...|      :.|..|.:
Human   924 KKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMH-- 986

  Fly   774 SVTKLTDLKELTAHGTTKYCLVSQDADTD----GDVETKLYKGNVIPTCGGGAQVVFNDVECLKQ 834
              ||:.:|:.|.:        |||.::.|    .|:.....:.|:..|   ...::.||....||
Human   987 --TKIDELRTLDS--------VSQISNIDLLNLRDLSNGSEEDNLPNT---QLDLLGNDYLVSKQ 1038

  Fly   835 --KSPVHSPTRKRPSNGNISAL 854
              :..:..|.|:...:.:|.|:
Human  1039 VKEYRIQEPNRENSFHSSIEAI 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	150/445 (34%)
		Kinesin	42..452	CDD:278646	149/440 (34%)
		MKLP1_Arf_bdg	735..837	CDD:293148	21/113 (19%)
KIF20B	NP_001271188.1	KISc_KIF23_like	57..477	CDD:276819	150/445 (34%)
		Kinesin	64..479	CDD:278646	149/440 (34%)
		Smc	629..1455	CDD:224117	88/458 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	829..866		9/38 (24%)
		Necessary and sufficient for interaction with SHTN1. /evidence=ECO:0000250|UniProtKB:Q80WE4	1050..1107		2/11 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1247..1275
		DUF342	<1268..1357	CDD:302792
		Interaction with PIN1. /evidence=ECO:0000269|PubMed:11470801	1560..1820
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1760..1781

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850