DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pav and kif20a

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_002936881.1	Gene:	kif20a / 496538	XenbaseID:	XB-GENE-967269	Length:	910	Species:	Xenopus tropicalis

Alignment Length:	757	Identity:	208/757 - (27%)
Similarity:	353/757 - (46%)	Gaps:	136/757 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKARDPVNVFCRVRP-----LQSDADLTSLRVKNSTTIALN-PQDQLLQHHKPHNGAQREVQYIF 89
            :::.|.|.|:.|:||     |:...|...:.|:|..|:.|. |:|.....:......|...::.|
Frog    57 EESNDKVMVYVRIRPFVDGELEKKEDQGCVEVENEETLVLRAPKDSFAMKNTERGLGQSVHKFTF 121

  Fly    90 KHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLF 154
            ..:|.|:..|:..:....:.:|::.|.|:|.|::|||||.||||:|:.|..:.|||:||.:.::|
Frog   122 SQLFGPEVDQKQFFDGTMRQVVKDALNGQNWLIYTYGVTNSGKTFTIQGTSKDRGILPRSIALIF 186

  Fly   155 RTISDYQAKKFVFKP---------------DKLNGFEILS---EEDAL--LERQHEMNQRFAG-- 197
            .:..|...|....||               ::|....:||   ||:.:  |:|....:|..||
Frog   187 NSAQDRLYKSSDLKPLSNEVMWLDSKQVRQEELKKVSLLSNLREEELMTPLKRSGNESQVRAGTS 251

  Fly   198 ------------SGRFAFRHKDSDPEIASQASVEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLL 250
                        :.:|..:......|..|:.:.:.:..|....|...|::|:|.||||..|||||
Frog   252 VSFDSGIGGLSSTSQFVNQTCSQLEETCSRWNDQEVVSLQEAADVQLSIWVSYYEIYNEFVYDLL 316

  Fly   251 E--DSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRS 313
            :  .||..:...:..:.||.|.:.:|..:|.:.|.:.|:|.::.::|:|.:....|.||..||||
Frog   317 DFMPSGPNRKRTTLRLCEDRNGNPYVKDLTWINVHSAEEAWKILRVGRKNQSFASTHLNQNSSRS 381

  Fly   314 HSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLREAGNINNSLMT 378
            ||:|:||::.    .||:|.:..:    :|:||..||||||| .:.:.:|.||:||.|||.||.|
Frog   382 HSIFSIRILH----MQGKNDLTPK----ISELSFCDLAGSER-CKDQRSGDRLKEATNINTSLHT 437

  Fly   379 LRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVM 443
            |..|:..||:||   ...|....||:||||:|.:|:.||.|.|:..|||.||.....|||.:..|
Frog   438 LGRCITVLRQNQ---QQKLRQNVVPFRDSKLTRIFQAYFTGRGKSCMIVNINQCASTYDETLYAM 499

  Fly   444 KFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFKIAVNN--LNELGIPEAKDLEVDVGLVYSLG 506
            ||:.:..  |:.:|.|:|.::   |..:...|...:..|.  .:|....|..|.|.:
Frog   500 KFSAIAS--QLVQAPPVKVNI---PSIQSLIKESTMLANRSYTDEEDADENSDEESE-------- 551

  Fly   507 PDFPAYEMDSPEAQIKIRELMHYLE---QRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQLRTE 568
                    ::..|:....||:..:|   :.|.|.::.:.|::|                 |:|.|
Frog   552 --------ETDIAKFNREELLQVIENMKELIVKERQEKLNMEI-----------------QIRKE 591

  Fly   569 LAS--LKAVYKQERDRSAALEKK----VRIHESSIDVLNNTLS--------KQERQIEELTFKLN 619
            :.|  :..:.:|::..|.:||.:    ..|:|..::.|..:|:        :::.:||||...|.
Frog   592 VCSEMMDMMQQQQKQHSESLEDERELLEEIYEGRLENLKESLTNYYKHELEERDERIEELEAALK 656

  Fly   620 EK----ENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVKLQERMRIKDEKLRLVS 680
            |.    .:|.:|....:|....:.|.:||.....|..:|:.:|...:::||.    |:|:   :.
Frog   657 EAMESVHSMPSQPTQREESLSVRRSKRLATAEASNTDKFKQELLNLKMELQS----KNEE---IE 714

  Fly   681 NILQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATR 722
            ...:.::.|...||              |||..::..|...|
Frog   715 KYKKMQEPPVSARS--------------YTADVDKKIVEGQR 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	150/456 (33%)
		Kinesin	42..452	CDD:278646	147/451 (33%)
		MKLP1_Arf_bdg	735..837	CDD:293148
kif20a	XP_002936881.1	KISc_KIF23_like	61..506	CDD:276819	150/456 (33%)
		Smc	<559..881	CDD:224117	46/222 (21%)
		GrpE	640..>721	CDD:383227	19/87 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920