DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and Klp54D

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001303355.1	Gene:	Klp54D / 47216	FlyBaseID:	FBgn0263076	Length:	760	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	172/786 - (21%)
Similarity:	303/786 - (38%)	Gaps:	236/786 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DPVNVFCRVRPL----QSDADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKH--VF 93
            |.:||..|||||    :.|...::|:...:..:.|...|  :...:.||   |:...:|.:  ||
  Fly   165 DNINVVVRVRPLNDKEKRDRHGSTLQFPGNGQVILEGND--VGQKRSHN---RDSVRVFTYNVVF 224

  Fly    94 QPDATQQDV--YAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRT 156
            :|.|||:|:  |:.:.: ::|..::|.:...|.||.||||||:|:||        |..|
  Fly   225 EPGATQEDILDYSGIKR-IIEMGIEGFSCTAFCYGQTGSGKTHTLTG--------PPDL------ 274

  Fly   157 ISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVEPI 221
                    ||.||:.                                  ||....:..::.:...
  Fly   275 --------FVGKPNP----------------------------------KDPRHGLIFRSFLYLF 297

  Fly   222 PLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVE 286
            .|:...:|..|.:..:::||||..|.|||.....:|.|..:..::...  .||..:..|:.:.::
  Fly   298 QLIKNRKDVNYVLKASFMEIYNERVIDLLNPGSARKPLAVRWSKKSGG--FFVENLFTVDCEELD 360

  Fly   287 DALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLA 351
            |.|.|.:.|.:.:.:|...:|..|||||::..:.::   :|.|.:..|...::   .:::.||||
  Fly   361 DLLAVLEEGMRNRAVGSHAMNDHSSRSHTILTVHIL---SDQQTDGGVFLSKH---GKINFVDLA 419

  Fly   352 GSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNY 416
            |||.:.:|.:.|..|.||.|||.|||.|..|:..|.:::....:      :|||||::|.:..:.
  Fly   420 GSELTKKTMSEGKTLEEANNINKSLMVLGYCISSLSDSKKRTGH------IPYRDSQLTKLLADS 478

  Fly   417 FDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATP-MKQDLGLTPGRRKANKLFKIA 480
            ..|.|...||.|::|...::.|.:..:::|...:.:   |..| :|.|      .|:|
  Fly   479 LAGNGVTLMIACVSPAHYNHAETLNTLRYASRAKRI---RTKPVIKMD------PREA------- 527

  Fly   481 VNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKKLRANLD 545
                                |:.||..|..|.:|::...:..:.  :|:  |.......:...|:
  Fly   528 --------------------LILSLKRDIHALQMENDHLKAALN--LHH--QAAPNGGPVENLLE 568

  Fly   546 IKCDSFR------------QMLMNLDRDNLQLRTELASLKAVYKQERDRSAALEKKVRIHESSID 598
            ::.|...            |.|..||      .:|||.|..:|..|
  Fly   569 LQLDRVSSGGGVPVPKVDLQRLPELD------GSELAELVKLYMVE------------------- 608

  Fly   599 VLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRV 663
              |.:|    ||         |..::.|.:                          |..||:|.:
  Fly   609 --NESL----RQ---------ENNHLFTVR--------------------------ETILRDQEI 632

  Fly   664 KLQERMRIKDEKLRLVSNI-LQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATRTDIYA 727
            ..:|..|:. :||..|:.: ::|..:|:.|.                .:.|.....|.  |:|:.
  Fly   633 VCRENERLL-KKLEDVNKVCVRSPLIPARPA----------------ISPTTGKETPG--TEIWT 678

  Fly   728 TPRH-----------GAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDL 781
            .|..           ....:.|.:||:.:|..:..:.|.|..:.:  :...:.|....:||..:|
  Fly   679 NPEPLQSPPGPDLPIEQRMSENANRRTDTAQKRIDQKRIAKNILI--MANAFRKPDSDITKELNL 741

  Fly   782 KELTAH 787
            ....||
  Fly   742 NPEEAH 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	111/422 (26%)
		Kinesin	42..452	CDD:278646	108/417 (26%)
		MKLP1_Arf_bdg	735..837	CDD:293148	12/53 (23%)
Klp54D	NP_001303355.1	KISc	166..520	CDD:214526	112/432 (26%)
Klp54D	NP_001303355.1	KISc	166..512	CDD:276812	110/421 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437883
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940