DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and Klp64D

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	188/758 - (24%)
Similarity:	319/758 - (42%)	Gaps:	207/758 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DKARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQ-YIFKHVFQ 94
            |...:.|.|..|.||:    |...|.....:.|:::..::.:...||:..|....: |.|.:||.
  Fly    15 DDEIENVRVVVRTRPM----DKNELSAGALSAISVDKINRAITVMKPNATANEPPKTYYFDNVFD 75

  Fly    95 PDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGN---LRHRGIMPRCLDVLFRT 156
            ..:.|.|:|...|:|:|:.:|:|.|..:..||.||:||||||:||   .:.:||:|.....:|..
  Fly    76 GGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGH 140

  Fly   157 ISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVEPI 221
            |:  :||:                           ||:|.
  Fly   141 IA--KAKE---------------------------NQKFL------------------------- 151

  Fly   222 PLLGLDEDNMYSVFVTYIEIYNNSVYDLL-EDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTV 285
                        |.|:|:||||..|.||| :|.|  |:|:   ::|..:..:||..::...|...
  Fly   152 ------------VRVSYMEIYNEEVRDLLGKDVG--KSLE---VKERPDIGVFVKDLSGYVVHNA 199

  Fly   286 EDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDL 350
            :|...:.::|.|.:.:|.|.:|.||||||::|:|.:.::   ..||.   |.|::.:.:|.||||
  Fly   200 DDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERS---ELGEG---DVQHVRMGKLQLVDL 258

  Fly   351 AGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKN 415
            |||||.|:|:.:|.||:||..||.||..|...:..|.:.:        ...:|||:||:|.:.::
  Fly   259 AGSERQSKTQASGQRLKEATKINLSLSVLGNVISALVDGK--------STHIPYRNSKLTRLLQD 315

  Fly   416 YFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFKIA 480
            ...|..:..|...|:|...:|.|.:..:::|...:.:|                    |::
  Fly   316 SLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQ--------------------NRM---- 356

  Fly   481 VNNLNELGIPEAKDL--------------EVDVGLVYSLGPDFPAYEM------DSPEAQIKIRE 525
              ::||    |.||.              :::.|  .||..:.|:.|.      |..||.::| |
  Fly   357 --HINE----EPKDALLRHFQEEIARLRKQLEEG--DSLEEEPPSSEEEEDTADDELEAPLEI-E 412

  Fly   526 LMHYLEQRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQLRTELASLKAVYKQERDRSAALEKKV 590
            |.....|.:||:.|.:..   |.|:.::.|.....::   :.|:...|...:..|::..:||.|:
  Fly   413 LESSTIQAVEKKPKKKRE---KTDAEKEELAKRKNEH---QKEIEHAKTEQETLRNKLVSLEGKI 471

  Fly   591 RI-------------------------HESSIDVLNNTLSKQ--ER-QIEELTFKLNEKENMLTQ 627
            .:                         ||.|.:.|..||.::  || .|||....|.:....:|:
  Fly   472 LVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATERIDIEERYSTLQDASTGITK 536

  Fly   628 KEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVKLQERMRIKDEKLRLVSNILQSEDLPSLP 692
            |.|...:......|:||.:..:::||.|        .:.|.:|....:|.|...:|.|    .:|
  Fly   537 KIHRVMQMLMGVKSELADQQQEHQREKE--------GIYENIRSLSRELALCELVLNS----YVP 589

  Fly   693 RSQSSENILNE-----KDRG-------AYTARTEESSVPATRT 723
            :...|  ::|:     :|.|       |||.......:.|.:|
  Fly   590 KEYQS--MINQYTHWNEDIGEWQLKCVAYTGNNMRKHISAHKT 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	119/419 (28%)
		Kinesin	42..452	CDD:278646	117/414 (28%)
		MKLP1_Arf_bdg	735..837	CDD:293148
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	119/421 (28%)
		Kinesin	26..352	CDD:278646	117/414 (28%)
		RILP-like	<437..556	CDD:304877	25/121 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940