DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and Klp3A

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster

Alignment Length:	1005	Identity:	215/1005 - (21%)
Similarity:	359/1005 - (35%)	Gaps:	325/1005 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 ARDP--VNVFCRVRPL-QSDADL-TSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKHVF 93
            :.||  |.|..||||| ||:.|. ..:.|:.|...|            |.....|...|.:.:||
  Fly     3 SEDPSCVAVALRVRPLVQSELDRGCRIAVERSADGA------------PQVTVNRNESYTYNYVF 55

  Fly    94 QPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTM----TGNL-RHRGIMPRCLDVL 153
            ..|.:|:|::....|..|:.||.|.|..:..||.|||||||||    .|.| .|.|::||.:..:
  Fly    56 DIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDI 120

  Fly   154 FRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASV 218
            |..|::.|::                                       ||
  Fly   121 FTAIAEMQSE---------------------------------------FR-------------- 132

  Fly   219 EPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVK 283
                         ::|..:::|:|....|||.......|....  |||..|| :.:.|:||:.|.
  Fly   133 -------------FAVTCSFVELYQEQFYDLFSSKTRDKATVD--IREVKNR-IIMPGLTELVVT 181

  Fly   284 TVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLV 348
            :.:...:....|...:.:..|.:|..|||||::|.:.||....|.        :|::|.|:.:||
  Fly   182 SAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKLDG--------KQSVTTSRFNLV 238

  Fly   349 DLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMF 413
            |||||||.|:|..:|.|.:|..|||..|:.|...:.       |..:|.|...:|||.||:|.:.
  Fly   239 DLAGSERCSKTLASGDRFKEGVNINKGLLALGNVIN-------ALGSGQAAGYIPYRQSKLTRLL 296

  Fly   414 KNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQ------------------------- 453
            ::...|.....||.|::|...:..|.:..:::|:...:::
  Fly   297 QDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLR 361

  Fly   454 ----------------------------------IARATPMK---------QD------------ 463
                                              :|.|..::         ||
  Fly   362 VELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQS 426

  Fly   464 -LGLTPGRRKA------------------NKL---FKIAVNNLNELGIPEAKDLEVDVGLVYSLG 506
             |.||....:|                  |||   .:....|.|..|..|.:|..:.|..|:
  Fly   427 LLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVH--- 488

  Fly   507 PDFPAYEMDSPEAQI-------------------------KIRELMH-YLEQRIEKR-------K 538
                 .|:...:.::                         ::.|::| :.|:...|:       :
  Fly   489 -----VELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELR 548

  Fly   539 KLRANLDIKCDSFRQMLMN---LDRDNLQLRTELASLKAVYKQERDRSAALEKKVRIHESSI--- 597
            .:...||:|.:...:::.|   ||.|:..::..|.:.| :...|.:|...:::...|....|
  Fly   549 NINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQK-IDDLEAERRDLMDQLRNIKSKDISAK 612

  Fly   598 --DVLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLRE 660
              :.....|...|::|.:|..||..:.|:|..::.|:|| .:..|:::..            ::|
  Fly   613 LAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREK-IQNLSTEIRT------------MKE 664

  Fly   661 QRVKLQERMRIKDEKLRLVSNILQSE--DLPSLPRSQSSENI----LNEKDRGAYTARTEESSVP 719
            .:|||...||.:.||.|....:.:.|  .|.|..|...||.:    |:.|.|.....:.|| ::.
  Fly   665 SKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEE-ALA 728

  Fly   720 ATRTDIYATPRHGAAAANNRHRRSRSAG------------DKWLEHRAANPVPLGTIMQPYLKNR 772
            |.:....|..|..:|.| .||:...:.|            |.|::..          ::..|...
  Fly   729 ANKRLKDALERQASAQA-QRHKYKDNGGSAAGSSNANAKTDSWVDRE----------LEIILSLI 782

  Fly   773 KSVTKLTDLKELTAHGTTKYCLVSQDADTD-----------GDVETKLYKGNVIPTCGGGAQVVF 826
            .:...|..|.|..|.....|.|:.|:..:|           ..:|.:|...|.
  Fly   783 DAEHSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRNA------------ 835

  Fly   827 NDVECLKQK-SPVHSPTRKRPSNGNISALG 855
             .:..|:|| .|....:|.|.....:.:||
  Fly   836 -QISDLQQKVCPTDLDSRIRSLAEGVQSLG 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	117/423 (28%)
		Kinesin	42..452	CDD:278646	113/416 (27%)
		MKLP1_Arf_bdg	735..837	CDD:293148	21/125 (17%)
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	115/424 (27%)
		Kinesin	14..335	CDD:278646	113/416 (27%)
		Smc	<396..>994	CDD:224117	98/516 (19%)
		FlaC	522..633	CDD:225888	21/111 (19%)
		TCR	1075..1110	CDD:281618
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437965
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840