DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and Kif20b

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_006231343.1	Gene:	Kif20b / 309523	RGDID:	1308497	Length:	1781	Species:	Rattus norvegicus

Alignment Length:	989	Identity:	261/989 - (26%)
Similarity:	434/989 - (43%)	Gaps:	213/989 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KARDPVNVFCRVRPL-QSDADLTS---LRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFKHV 92
            ::::.:.|..|:||. ||:....:   ::|.:|.|:.|.....:|.|....:..|...::.|..|
  Rat    54 ESKNYLQVCLRIRPFTQSEKGHEAEGCVQVLDSQTVLLKDPQSILGHLSEKSSGQMAQKFSFSRV 118

  Fly    93 FQPDATQQDVY-AAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRT 156
            |.|:.:|::.: ..:.|| |::||||.:.|:||||:|.||||||..|...:.||:||.|:|||.:
  Rat   119 FGPETSQKEFFQGCIMQP-VKDLLKGHSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDS 182

  Fly   157 ISDYQAKKFVFKPDKLNGFEILS-----EEDA----LLERQHEMNQRFAGSGRFAFRHKDS---- 208
            :.:....|..|||.:...:..||     ||.|    ||.:..|:.           .|.||
  Rat   183 LQERLYTKMSFKPHRCREYLQLSSDQEKEESANKNTLLRQIKEVT-----------IHNDSYDIL 236

  Fly   209 ---------DPEIASQASVEPIPLLGLDEDNM-YSVFVTYIEIYNNSVYDLL--EDSGIQKTLQS 261
                     .||.  :.::.......|:.||: |||:|::.||||.|:|||.  ..|.:||   .
  Rat   237 CGRLTNSLTIPEF--EETMNNCEQSSLNVDNIKYSVWVSFFEIYNESIYDLFVPVSSKLQK---R 296

  Fly   262 KIIR--EDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQA 324
            |::|  :|...:.|:..:..::|...::|..:.::|.|.:.:..|.||..||||||:|.||::|.
  Rat   297 KMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGVKHQSVAFTKLNNASSRSHSIFTIRILQI 361

  Fly   325 PTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLREN 389
             .||:...|.:      ||:|||.||||||||.:|::.|.|||||||||.||:||..|:..|:.
  Rat   362 -EDSEIPRVTR------VSELSLCDLAGSERSMKTQSEGERLREAGNINTSLLTLGKCISVLKN- 418

  Fly   390 QLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQI 454
               :......:.||:|:||:||.|:::|.|:|::.||:.|:.....|||.:.|:||:.:.|:|.:
  Rat   419 ---SDKSKIQQHVPFRESKLTHYFQSFFTGKGKICMIINISQCCSAYDETLNVLKFSTVAQKVYV 480

  Fly   455 A-----------RATPMKQDLGLTPGRRKANKLFKIA------VNNLNELGIPEAKDLEVDV--- 499
            .           .:|...||:.|  |....||:..:.      .|:|.:  :.|.:||..|:
  Rat   481 PDTLSSSQEKSFGSTKSLQDVSL--GSNLDNKILNVKRKTVSWENSLED--VVENEDLVEDLEEN 541

  Fly   500 GLVYSLGPDFPAYEMDSP--EAQI--------KIRELMHYLEQRI--EKRKKLRANLDIKCD--- 549
            ....::..:....:.|.|  |..:        |:.:|:..|::|:  ||::||.....|:.:
  Rat   542 EETQNMETELTDEDSDKPLEEGGVCAGHGKNKKLLDLIENLKKRLINEKKEKLTLEFKIREEVTQ 606

  Fly   550 -----------SFRQMLMNLDRDNLQLRTE--LASLKAVY-----KQERDRSAALEKKVRIHESS 596
                       .|::.|:: :|:.|:...|  ||..|.:.     .|:...|.....::...||.
  Rat   607 EFTQYWSQREADFKETLLH-EREILEENAERRLAIFKDLVGKPGESQDEPASRFCTMELETEESH 670

  Fly   597 --------IDVLNNTLSKQERQIEE-----------------LTFKLNE--------KENMLTQK 628
                    .|.|.:.::..::|.|.                 |..|.|:        ||.::..:
  Rat   671 NYVGVEDIFDSLEDDVTDIKKQAELAHLYITSLVDPQEAIACLQLKYNQVKAELAETKEELIKAQ 735

  Fly   629 EHEKEK------QKKKFSSKLAVESDKNK------REFELKLREQRVKLQERMRIKDEKLRL--- 678
            |..|.|      |..|.|||:......||      .|...|.|.|  ...||.|:.::.|:|
  Rat   736 EELKNKESDSLVQALKTSSKVDTSLISNKSTGNETTEMPKKSRTQ--THSERKRLNEDGLQLGEP 798

  Fly   679 ---VSNILQSEDLPSLPRSQSS-ENILNEKDRGAYTARTEESSVPATRTDIYATPRHGAAAANNR 739
               ...||.|   |.:...|.. |.:......||    .|:|.|...:              |..
  Rat   799 PAKKGLILIS---PPITEDQDKREEMQQSVSEGA----EEDSRVLQEK--------------NEE 842

  Fly   740 HRRSRSAGDKWL-----EHRAANPVPLGTIMQPYLKNRKSVTKLTDLKELTAHGTTKYCLVSQDA 799
            .:|..:.|:..|     |....|...:....|......|:.:...:::::.|    .|.|.:.:.
  Rat   843 LKRLLTIGENELRNAKEEKAELNKQVVSLQQQLCFFEEKNSSLRAEVEQIQA----SYDLAAAEL 903

  Fly   800 DTDGDVETKLYKGNVIPTCG---GGAQVVFNDVECLKQKSPVHSPTRKRPSNGNISALGGGAVPS 861
            .|...|..: .|..::...|   ..|:.:.::|..:||........|...|..:||.:
  Rat   904 HTQRAVNQE-QKDRILQLSGKMETAARRIESNVSQIKQMQTKIDELRSLDSPSHISKI------- 960

  Fly   862 TVTSAQDVASRCNL 875
            .:.:.||::|..||
  Rat   961 DLLNLQDLSSGANL 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	155/446 (35%)
		Kinesin	42..452	CDD:278646	155/441 (35%)
		MKLP1_Arf_bdg	735..837	CDD:293148	19/109 (17%)
Kif20b	XP_006231343.1	KISc_KIF23_like	58..476	CDD:276819	155/445 (35%)
		Kinesin	64..478	CDD:278646	155/441 (35%)
		COG1340	1048..1337	CDD:224259
		Rootletin	1097..>1248	CDD:291694
		DUF4349	1180..1332	CDD:305044
		Ax_dynein_light	<1227..1302	CDD:287215
		Tropomyosin	1251..1479	CDD:278679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820