DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and kif23

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_021323261.1	Gene:	kif23 / 30627	ZFINID:	ZDB-GENE-991019-4	Length:	982	Species:	Danio rerio

Alignment Length:	1008	Identity:	371/1008 - (36%)
Similarity:	539/1008 - (53%)	Gaps:	182/1008 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KAVPRTPMRVVPKTPRVHQTVEKQRRDTSDKARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALN 66
            :|..:||.|..||.|             |:..:|||.|:||||||.::.:...:.|.::|||.|:
Zfish     4 QAKGKTPRRPPPKKP-------------SNNQKDPVGVYCRVRPLGAEDEECCIEVISNTTIQLH 55

  Fly    67 PQDQLLQHHKPHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSG 131
            ..|.|..:   .||..:|.||.||.||....||::::..||:||.::|:.|:|.|||||||||||
Zfish    56 APDGLKAN---RNGEFKETQYSFKKVFGIKTTQRELFEDVAKPLAQDLIHGKNGLLFTYGVTGSG 117

  Fly   132 KTYTMTGNLRHRGIMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQ--- 193
            ||:||||:....|::||.||::|.:|..||||::|||||..||.|:.::.||||:||...:|
Zfish   118 KTHTMTGSPGQGGLLPRSLDMIFNSIGPYQAKRYVFKPDDKNGMEVQNQVDALLDRQKRDSQTSV 182

  Fly   194 -RFAGSGRFAFRHKDSDPEIASQAS-VEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDS--- 253
             :...:.|.       |||.|...| .|.....|:|||:.|||||:|||||||.:|||||::
Zfish   183 PKTPNTRRV-------DPEFADMISPEEACKAEGVDEDSSYSVFVSYIEIYNNYIYDLLEETPFD 240

  Fly   254 --------------GIQKTL--QSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRKRMG 302
                          .|.:.:  ||||:|||.|.:|:|.|.||||||:.|:|.|||..|||::|:.
Zfish   241 PIKPKWNGAGTPVRNITEFIPPQSKILREDQNHNMYVAGCTEVEVKSTEEAFEVFWRGQKKRRIA 305

  Fly   303 HTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGVRLR 367
            :|.||.|||||||||.::|.|||.|:.|:||:||:..:.||||.|||||||||:|||:..|.|||
Zfish   306 NTQLNRESSRSHSVFIVKLAQAPLDADGDNVLQDKNQVNVSQLCLVDLAGSERTSRTRAEGNRLR 370

  Fly   368 EAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCINPR 432
            ||||||.||||||||:|.|||||:..:|    |.|||||||:||:|||||||||:|.|:||:||:
Zfish   371 EAGNINQSLMTLRTCIEVLRENQMCGTN----KMVPYRDSKVTHLFKNYFDGEGKVRMVVCVNPK 431

  Fly   433 IEDYDENMQVMKFAEMTQEVQIARATPMKQDL-GLTPGRRKANKLFKIAV-NNLNELGIPEAKDL 495
            .:||:|.:.||:||||||||::||  |:.:.: |...|||:.|:.||..: ..|.|.|.|...|.
Zfish   432 ADDYEETLLVMRFAEMTQEVEVAR--PVDRPICGFAAGRRQRNQAFKEELTRRLEERGGPVDGDC 494

  Fly   496 EVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKKLRANLDIKCDSFRQMLMN--- 557
            ...:..:....|..|..|:..|...:.:..|:    :.:|||.|:|..:..:.:....||.:
Zfish   495 PTVLNQLLQAFPPLPPCEISGPNDDVTLPRLI----EALEKRHKIRQMMIEEYNKTATMLKSVLQ 555

  Fly   558 ------LDRDNL--QLRTELASLKAVYKQERDRSAALEKKVRIHESSIDVLNNTLSKQERQIEEL 614
                  |.::|:  :.|.:|.....:.:.:::....||||.::.|..||:|..|.:..|.....|
Zfish   556 EQDGNILSKENVIQEQRGKLGEKDKMLQNQKNEIDRLEKKSKMLEYKIDILQKTTNIYEEDKRSL 620

  Fly   615 TFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQRVKLQERMRIKDEKLRLV 679
            ..:|..:|..|.::..||.:.:.:....::....|.::|.|.::..:::::|.::.:|||||:.:
Zfish   621 QNELESREQRLQREMSEKRRIEARMQGMVSDTKLKWEKECERRVNAKQLEMQNKLWVKDEKLKQL 685

  Fly   680 SNIL---------------QSEDLP------------SLPRSQSS----ENILN----------- 702
            ..|:               :.:.:|            |...||||    |.|.|
Zfish   686 KAIVTEGKTENRQPQRPSREKDKVPPKRSASPSPAPSSYNGSQSSLSSLEPIYNFSQTVRPDTHF 750

  Fly   703 -------------EKDRGAYTARTEES-SVPATRTDIYATP-----RHGAAAANN---------- 738
                         |.::|...:|.:.| |.|..|......|     |.|...|..
Zfish   751 PRAGSVSVASCISEWEQGVPQSRRQGSQSPPDCRNRTQGLPDSLSRRRGRCWAREVPVQPADVDL 815

  Fly   739 -------------RHRRSRSA-GDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKELTAHGT 789
                         .||||.|| |::|::|:....|.|.|:|||.:.|   ..|:....|......
Zfish   816 EETVHWTGPPVRPLHRRSHSAGGERWVDHKPTTNVDLDTVMQPNIPN---AIKVNAPNEKALSKC 877

  Fly   790 TKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKR--------- 845
            .||.|..|:..:||:::|||.||.|..|.|||..|.|.|:|.|||::||.:..::|
Zfish   878 DKYVLTHQEVASDGEIQTKLIKGEVFKTRGGGQSVQFTDIETLKQETPVAASRKRRSSESGPDSE 942

  Fly   846 PSNGNISALGGGAVPSTVTSAQDVASRCNLGIE 878
            |..||.:               ||.:||::.:|
Zfish   943 PMEGNWT---------------DVETRCSVAVE 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	230/438 (53%)
		Kinesin	42..452	CDD:278646	227/433 (52%)
		MKLP1_Arf_bdg	735..837	CDD:293148	42/125 (34%)
kif23	XP_021323261.1	KISc_KIF23_like	24..449	CDD:276819	230/438 (53%)
		SMC_N	<526..699	CDD:330553	37/176 (21%)
		MKLP1_Arf_bdg	825..928	CDD:318691	43/105 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592159
Domainoid	1	1.000	425	1.000	Domainoid score	I594
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11491
Inparanoid	1	1.050	584	1.000	Inparanoid score	I972
OMA	1	1.010	-	-		QHG50087
OrthoDB	1	1.010	-	-		D161187at33208
OrthoFinder	1	1.000	-	-		FOG0006430
OrthoInspector	1	1.000	-	-		oto40305
orthoMCL	1	0.900	-	-		OOG6_104864
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	1	1.000	-	-		X5390
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300