DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pav and kif20bb

DIOPT Version :9

Sequence 1:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster
Sequence 2:	XP_021335955.1	Gene:	kif20bb / 100007502	ZFINID:	ZDB-GENE-030131-9684	Length:	1547	Species:	Danio rerio

Alignment Length:	907	Identity:	243/907 - (26%)
Similarity:	394/907 - (43%)	Gaps:	213/907 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KTPRVHQ-TVEKQRRDT----SDKARDPVN-------VFCRVRPLQS-------DADLTSLRVKN 59
            |..||.. |||..|:|.    |..:||.|:       |:.||||..|       ..|..|:...:
Zfish     9 KPDRVDSITVEDLRKDLFSEFSKLSRDSVSLEKEHLQVYLRVRPFTSTERAEGESQDCISIEPPD 73

  Fly    60 STTIALNPQDQLLQHHKPHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFT 124
             |.|...|:..|...|....|.|...::.|..|:.|:.||::::....:.||:.:|.|.|||:||
Zfish    74 -TVILKAPKASLTARHSERFGPQLAQRFQFSQVYGPETTQKEIFDGTTKSLVKEVLDGGNSLIFT 137

  Fly   125 YGVTGSGKTYTMTGNLRHRGIMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQH 189
            ||||.:|||:|..|.....||:||.|:|:|.:|......:...||.:...|..|::|....|..:
Zfish   138 YGVTNAGKTFTFLGPESDGGILPRSLNVIFNSIEGRIYLQNNIKPHRCVDFTRLTKEQQDEEATN 202

  Fly   190 EMN--QRFAGSGRFAFRHKDSDPEIASQASVEPIPL------------LGLDEDN--MYSVFVTY 238
            :.|  :|        |:..||...::|.:|......            :.||||:  .:||:|::
Zfish   203 KRNLLRR--------FKDNDSQKTLSSMSSSSCSSFDSSTSSDMNGDSVYLDEDSHVKFSVWVSF 259

  Fly   239 IEIYNNSVYDLLE----DSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEVFQMGQKRK 299
            .||||.|::|||:    .|..:..|:   :.:|...:.||..:..|:|.:.::||:|.::|:|.:
Zfish   260 CEIYNESIHDLLDFVPNGSHRRNALR---LAQDVKSNSFVKDLKWVQVNSADEALKVVKIGRKNQ 321

  Fly   300 RMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERSSRTKNTGV 364
            ....|.||..||||||:|:||:::  .:..|...||     |:|:|||.|||||||.:||:|.|.
Zfish   322 SFSSTKLNNISSRSHSIFSIRMLR--IEDVGVPRVQ-----TISELSLCDLAGSERCARTQNRGE 379

  Fly   365 RLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEGQVSMIVCI 429
            ||:||||||.||:||..|:..||.||   :.....:.:|:|:||:||..:.||.|.|:..||:.|
Zfish   380 RLKEAGNINTSLLTLGKCINALRLNQ---TQSKFHQHIPFRESKLTHYLQGYFCGRGKACMIINI 441

  Fly   430 NPRIEDYDENMQVMKFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFKIAVNNLN--------- 485
            |.....|||.:.|:||:.:.|:|.:....| ...:.|   :|.|..:..| :||.:
Zfish   442 NQCASVYDETLNVLKFSAVAQKVVVLNPKP-APSIAL---KRSARDVSMI-INNADKKDWTRRSS 501

  Fly   486 ----ELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSP-------------------EAQIKIRELM 527
                |:.:.:.::.|.|        .|....|::|.                   |.|:||.||.
Zfish   502 IMGWEMSLEDVQEDEND--------EDMDEEEVESDDESIVDRTVLETVENQELCELQVKIEELQ 558

  Fly   528 HYLEQRIEKRKKLRANLDIK---CDSFRQMLMNLDRD---NLQLRTELASLKA------------ 574
            ..|.:  |:.:||.....|:   ...|.::..|:::|   .||...|:...:|
Zfish   559 EKLIK--EESEKLTLEARIREEVTTEFMELFSNMEKDYSERLQREKEIVEERAERRLEILKNLVN 621

  Fly   575 --VYKQERDRSAALEKKVRIHESSIDVLNNTLSK-----------------QERQIEELTFKLNE 620
              :.:...|.:||.|.|:.:.::.|:.:.:.|:|                 ...::..|..:|.|
Zfish   622 RTIEEMTTDENAAKEAKMELLDTMIEAMRSDLTKIKGDAESVQLCLANVPESPGKLSHLRTELEE 686

  Fly   621 KENMLTQKEHEKEKQKKKFSSKLAVESDKN------KREFELKLREQRVKLQERMRIKDEKLRLV 679
            .:..|.:.:.:...:.|:|........|.|      .|.:|    .|:|:.||.|.|..||..:|
Zfish   687 IKAELLKSQQQLSLKSKEFEESCIQMQDLNDQLLQATRNYE----NQKVRCQELMSICQEKDDMV 747

  Fly   680 SNIL----QSEDLPSLPR-----------------------------SQSSENILNE-------- 703
            |.:.    |:::..|..|                             ||.::.:..|
Zfish   748 SKLQTALEQNDEAASKDRALINNIREEILHFKNSCKCKLNEEHDEMTSQKNQQLQQELKMKDDQL 812

  Fly   704 -----------------KDRGAYTARTEESSVPATRTDIYATPRHGAAAANNRHRRSRSAGD 748
                             .||.:...:|.|::|...|.::........|.||......:.|.:
Zfish   813 NQLKLEHASLEKAMRDISDRLSELTQTHEATVAMERAEVNKVTNENKALANELDELQQRANE 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	156/448 (35%)
		Kinesin	42..452	CDD:278646	154/436 (35%)
		MKLP1_Arf_bdg	735..837	CDD:293148	3/14 (21%)
kif20bb	XP_021335955.1	Motor_domain	42..462	CDD:328930	154/441 (35%)
		SMC_N	<544..1161	CDD:330553	62/337 (18%)
		TOP2c	<1287..1532	CDD:330395
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820