DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14997 and AIFM1

DIOPT Version :9

Sequence 1:	NP_647877.1	Gene:	CG14997 / 38514	FlyBaseID:	FBgn0035515	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_004199.1	Gene:	AIFM1 / 9131	HGNCID:	8768	Length:	613	Species:	Homo sapiens

Alignment Length:	365	Identity:	74/365 - (20%)
Similarity:	126/365 - (34%)	Gaps:	129/365 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LVVGGGTGGCAMAAKLSSR-LGSDKVVVLEPEDKHYYQPMFTLIGGGMKRLDQSHRQMADVLPTK 110
            |::||||...|.|..:.:| .|:..::|.|..:..|.:|..:      |.|..|.    |...||
Human   135 LLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLS------KELWFSD----DPNVTK 189

  Fly   111 A----KW-VKEKALEFDPDNNTVSTSGGKTIKYDFLIIATGLQLNYGKIPGLVEALETPDSNVCS 170
            .    :| .||:::.|.|.:..||......|:...:.:.||.:         |..|:..|:.|
Human   190 TLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKK---------VVQLDVRDNMV-- 243

  Fly   171 IYSPKYVDHVYECLRRTNKGNAIFTFPNCPIKCAGAPQKIAYISE---------HYFRKMG---- 222
                           :.|.|:.| |:..|.|...|.|:.::.|..         ..|||:|
Human   244 ---------------KLNDGSQI-TYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRS 292

  Fly   223 ----RRD--NVNII----YNTSLPVIFGVKHYAEAL--------------------------MKL 251
                .|:  ::.||    ..:.|....|.|  |.||                          |:.
Human   293 LEKISREVKSITIIGGGFLGSELACALGRK--ARALGTEVIQLFPEKGNMGKILPEYLSNWTMEK 355

  Fly   252 IKRRNI---------TLNVQRNLVEVRHKDNIAVFEDLAKPGVHYEETYSMLHVTPPMSTPDVVA 307
            ::|..:         ::.|....:.::.||...|..|.....|..|              |:|.
Human   356 VRREGVKVMPNAIVQSVGVSSGKLLIKLKDGRKVETDHIVAAVGLE--------------PNVE- 405

  Fly   308 NCKKLVTPTGFVDVD------QLTLQHNKYSNVFAIGDSA 341
                 :..||.:::|      ::..:....||::..||:|
Human   406 -----LAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAA 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14997	NP_647877.1	Pyr_redox_2	59..342	CDD:285266	68/353 (19%)
AIFM1	NP_004199.1	Mitochondrial localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z0X1	1..31
		AIF-MLS	52..>133	CDD:317386
		Mitochondrial localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z0X1	63..89
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..127
		FAD-dependent oxidoreductase. /evidence=ECO:0000250	134..483		74/365 (20%)
		Pyr_redox_2	150..462	CDD:311792	67/350 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	446..451
		AIF_C	465..593	CDD:317164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810