DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14997 and AIFM3

DIOPT Version :9

Sequence 1:	NP_647877.1	Gene:	CG14997 / 38514	FlyBaseID:	FBgn0035515	Length:	457	Species:	Drosophila melanogaster
Sequence 2:	NP_001373743.1	Gene:	AIFM3 / 150209	HGNCID:	26398	Length:	605	Species:	Homo sapiens

Alignment Length:	411	Identity:	91/411 - (22%)
Similarity:	148/411 - (36%)	Gaps:	134/411 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 VLVVGGGTGGCAMAAKLSSRLGSDKVVVLEPEDKH--YYQPMFTLIGGGMKRLDQSHRQMA---- 104
            ||:||.|..|...|..|.....||: :||...|:|  |.:|..:      |.||....|:|
Human   197 VLIVGAGAAGLVCAETLRQEGFSDR-IVLCTLDRHLPYDRPKLS------KSLDTQPEQLALRPK 254

  Fly   105 --------DVLPTKAKWVKEKALEFDPDNNTVSTSGGKTIKYDFLIIATGLQLNYGKI---PGLV 158
                    :|| |:|:.|            ||.....|.:..|      |.:|.|.|:   ||
Human   255 EFFRAYGIEVL-TEAQVV------------TVDVRTKKVVFKD------GFKLEYSKLLLAPG-- 298

  Fly   159 EALETPDS---------NVCSIYSPKYVDHVYECLRRTNKGNAIFTFPNCPIKCAGA----PQKI 210
               .:|.:         ||.:|.:|:..:.|....|..|            :...||    .:..
Human   299 ---SSPKTLSCKGKEVENVFTIRTPEDANRVVRLARGRN------------VVVVGAGFLGMEVA 348

  Fly   211 AYISEHYFRKMGRRDNVNIIYNTSLPV-IFGVKHYAEALMKLIKRRNITLNVQRNLVEVRH---- 270
            ||::|       :..:|:::.....|. .|..:....||||:.:...:...:|..:.|:|.
Human   349 AYLTE-------KAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYMQTEVSELRGQEGK 406

  Fly   271 ------KDNIAVFEDLAKPGVHYEETYSMLHVTPPMSTPDVVANCKKLVTPTGFVDVDQLTLQHN 329
                  |.:..|..|:...|:      ..:..|..:....:..:.:      ||:.|::: :|.|
Human   407 LKEVVLKSSKVVRADVCVVGI------GAVPATGFLRQSGIGLDSR------GFIPVNKM-MQTN 458

  Fly   330 KYSNVFAIGDSASSP-----NSKTA----AAAAAQSPVVFKNVMA-------------AIEGKAP 372
             ...|||.||:.:.|     |.|..    ..|.||..|..:|::|             |:.||:.
Human   459 -VPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEMSTVPYLWTAMFGKSL 522

  Fly   373 TDIYDGYSSCPIVTGYSSCIL 393
            .  |.||..     |:...|:
Human   523 R--YAGYGE-----GFDDVII 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14997	NP_647877.1	Pyr_redox_2	59..342	CDD:285266	68/323 (21%)
AIFM3	NP_001373743.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..45
		Rieske_AIFL_N	70..164	CDD:239560
		Pyr_redox_2	195..493	CDD:400379	79/359 (22%)
		Reductase_C	512..>562	CDD:405449	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810