DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and dscama

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_021334866.1	Gene:	dscama / 568643	ZFINID:	ZDB-GENE-050310-7	Length:	2025	Species:	Danio rerio

Alignment Length:	249	Identity:	57/249 - (22%)
Similarity:	94/249 - (37%)	Gaps:	64/249 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DSNDVDNSIEAEEEKPRNRAFEADWLKFTKTPPTKLQQAD------GATIEIVCEMMGSQVP-SI 90
            |..:....::.:.:..:|::....    .|.||. :|..:      |..:.:.|.:....:| ||
Zfish   570 DEGEYSCHVQVQPQLFKNQSVHVT----VKVPPF-IQPFEFPRYSIGHRVFVPCVVRSGDLPISI 629

  Fly    91 QWVV-GHLPRSEL----DDLD---SNQVAEEAPSAIVRVRSSHIIDHVLSEARTYTCVGRTGSKT 147
            .|.. |....:.|    |::|   |.::     |.:.||.:.           ||||:.:..:..
Zfish   630 TWEKDGKSINASLGVTIDNIDFTSSLRI-----SNLQRVHNG-----------TYTCIAQNDAAV 678

  Fly   148 I-YASTVV--HPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEITWLN 209
            : |.|.::  .|||.      |..|..|.           .:.|.::.|.|.....||..|.|..
Zfish   679 VKYQSQLIVRVPPRF------KVQPQDQD-----------GIYGKSVILNCSADGEPRPTIEWKY 726

  Fly   210 NENKEIVQ--------GHRHRVLANGDLLISEIKWEDMGNYKCIARNVVGKDTA 255
            ::...:.|        |.|.::|.||.|||..:..||.|.|.|...|.||.|.:
Zfish   727 SKGAGVPQFQPIALNSGFRVQLLGNGSLLIKHVLEEDAGYYLCKVSNDVGADVS 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	22/71 (31%)
dscama	XP_021334866.1	Ig	124..217	CDD:325142
		I-set	236..311	CDD:254352
		IG_like	321..402	CDD:214653
		I-set	408..502	CDD:333254
		IGc2	524..579	CDD:197706	1/8 (13%)
		Ig	614..679	CDD:319273	17/80 (21%)
		Ig_DSCAM	708..787	CDD:143211	24/73 (33%)
		Ig	805..898	CDD:325142
		FN3	894..988	CDD:238020
		FN3	995..1092	CDD:238020
		fn3	1100..1186	CDD:306538
		fn3	1199..1282	CDD:306538
		Ig	1312..1377	CDD:319273
		fn3	1405..1471	CDD:306538
		FN3	1492..1563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900