DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpL2 and robo4

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	270	Identity:	61/270 - (22%)
Similarity:	98/270 - (36%)	Gaps:	56/270 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAKMNLHVCALALLLFGSIATVRGR------AVDLVDDSNDVDNSIEAEEEKPRNRAFEADWLK 59
            |:|:....|.....|.|.|:  |.||      ||......|.:.|:..      ||.:.....|:
Zfish   116 MDAQSQPIVLPDGSLFFFSV--VPGRKGQSHEAVYACIAHNSIGNATS------RNASLHIAALR 172

  Fly    60 FT-KTPPTKLQQADGATIEIVCE-MMGSQVPSIQWVVGHLPRSELDDL---DSNQVAEEAPSAIV 119
            .. :..|:.::.|.|....|.|. .:|...|::.|        ..|.:   .||:...|....::
Zfish   173 EDFRVQPSDVEVAIGEMATINCSPPVGHPEPNVTW--------RKDGILINSSNEHYTELKGKLI 229

  Fly   120 RVRSSHIIDHVLSEARTYTCVGRTGSKTIYASTV--VHPPRSSRLTPEKTYPGAQKPRIIYTEKT 182
                  |.....:::..|:|:         ||.:  |...|::||:........:||..:..:
Zfish   230 ------IAPAQKNDSGVYSCI---------ASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQ-- 277

  Fly   183 HLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGD--LLISEIKWEDMGNYKCI 245
                :|.:.|..|.....|...|.| :.|...:..|   |.|.|.|  |.|..:..:|||.|.|.
Zfish   278 ----LGESAQFFCEADGDPMPSIEW-SREQGPLPNG---RYLINPDHSLQIHYVTAQDMGRYSCT 334

  Fly   246 ARNVVGKDTA 255
            ..|.:|...|
Zfish   335 VENKLGVSVA 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	20/65 (31%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	15/60 (25%)
		I-set	71..168	CDD:254352	15/59 (25%)
		I-set	175..261	CDD:254352	21/108 (19%)
		Ig2_Robo	177..261	CDD:143201	21/106 (20%)
		I-set	265..350	CDD:254352	24/90 (27%)
		Ig	282..350	CDD:299845	21/67 (31%)
		FN3	373..448	CDD:214495
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900