DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and lrit1a

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001018174.2	Gene:	lrit1a / 553943	ZFINID:	ZDB-GENE-040924-5	Length:	643	Species:	Danio rerio

Alignment Length:	244	Identity:	43/244 - (17%)
Similarity:	78/244 - (31%)	Gaps:	76/244 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 GSQVPSIQW-VVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHVLSEARTYT--------- 138
            |:.:.|..| .:..:|...|.|:.:||::.....|.:.:::...:|  ||.....|
Zfish   116 GNSLSSFPWESLMDMPSLRLLDIHNNQLSSLPSEAALYMKNITYLD--LSSNNLLTVPAEVLNTW 178

  Fly   139 -----CVGRTGSKTIY-----------------------ASTVVHPPRSSRLTPEKTYPG----- 170
                 .:|...||.|.                       :.:|.......|....::..|
Zfish   179 LTIKPTLGAESSKLILGLHDNPWLCDCRLYDLVQFQKSPSLSVAFIDTRLRCADPESLSGVLFSD 243

  Fly   171 -----AQKPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLL 230
                 .|.||:..........:|:|:.|.|.....|..|:.|...:.|.:          ||.:|
Zfish   244 AELRRCQGPRVHTAVARVRSAVGNNVLLRCGTVGVPIPELAWRRADGKPL----------NGTVL 298

  Fly   231 ISE--------------IKWEDMGNYKCIARNVVGKDTADTFVYPVLNE 265
            :..              :.:.|.|.|.|.|.|..|  :|:..:..::|:
Zfish   299 LENSKEGIVWSILSVPAVSYRDTGKYICKATNYAG--SAEAVISLIIND 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	17/77 (22%)
lrit1a	NP_001018174.2	leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..119	CDD:290566	1/2 (50%)
		LRR_RI	<77..175	CDD:238064	13/60 (22%)
		leucine-rich repeat	85..108	CDD:275378
		LRR_8	108..167	CDD:290566	12/52 (23%)
		leucine-rich repeat	109..132	CDD:275378	3/15 (20%)
		leucine-rich repeat	133..156	CDD:275378	5/22 (23%)
		leucine-rich repeat	157..170	CDD:275378	3/14 (21%)
		LRRCT	199..243	CDD:214507	3/43 (7%)
		I-set	252..343	CDD:254352	21/102 (21%)
		Ig	259..333	CDD:299845	17/83 (20%)
		fn3	448..515	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900