DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and NCAM2

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_011527877.1	Gene:	NCAM2 / 4685	HGNCID:	7657	Length:	874	Species:	Homo sapiens

Alignment Length:	206	Identity:	49/206 - (23%)
Similarity:	83/206 - (40%)	Gaps:	43/206 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PTKLQQADGATIEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDH 129
            |.:.:|.:.|  |:||.:..|..|::.|:..:   .|:..:..|:.|..|.:.:      .|::.
Human   148 PQEFKQGEDA--EVVCRVSSSPAPAVSWLYHN---EEVTTISDNRFAMLANNNL------QILNI 201

  Fly   130 VLSEARTYTCVGRTGSK--TIYASTVV---HPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGS 189
            ..|:...|.|.||..::  ..:...:|   .||..|  .|:|::....:             .|.
Human   202 NKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIS--MPQKSFNATAE-------------RGE 251

  Fly   190 NIQLPCRVHARPRAEITWLNN-----EN-KEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARN 248
            .:...||....|...|:|..|     || |.|::|      :|.:|.:..|...|.|.|.|.|.|
Human   252 EMTFSCRASGSPEPAISWFRNGKLIEENEKYILKG------SNTELTVRNIINSDGGPYVCRATN 310

  Fly   249 VVGKDTADTFV 259
            ..|:|....|:
Human   311 KAGEDEKQAFL 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	21/69 (30%)
NCAM2	XP_011527877.1	Ig1_NCAM-2	46..137	CDD:143274
		I-set	47..136	CDD:254352
		I-set	142..218	CDD:254352	19/80 (24%)
		IGc2	153..214	CDD:197706	16/71 (23%)
		Ig	233..326	CDD:299845	29/110 (26%)
		I-set	240..323	CDD:254352	25/101 (25%)
		Ig5_NCAM-2	325..422	CDD:143278
		IG_like	333..420	CDD:214653
		IG_like	438..515	CDD:214653
		IGc2	439..507	CDD:197706
		FN3	521..613	CDD:238020
		fn3	619..703	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900