DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and ncam1a

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_009293555.1	Gene:	ncam1a / 30447	ZFINID:	ZDB-GENE-990415-31	Length:	1010	Species:	Danio rerio

Alignment Length:	221	Identity:	53/221 - (23%)
Similarity:	85/221 - (38%)	Gaps:	50/221 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 LKFTKTP-PTKLQQADGATIEIVCEMMGSQVPSIQWVVGHL---PRSE--LDDLDSNQVAEEAPS 116
            |.|...| |.:..:.|.|  :|:|:::.|..|:|.|....:   |.::  |..|.:|.
Zfish   115 LTFQYAPSPQEFNEGDDA--DIICDVISSPPPTIIWRYKKMRIQPETDVRLKVLSNNH------- 170

  Fly   117 AIVRVRSSHIIDHVLSEARTYTCVGRTGS------KTIYASTVVHPPRSSRLTPEKTYPGAQKPR 175
              :::|.....|.     ..|||.||..:      :.|.....|.|...:|
Zfish   171 --LQIRGIKKTDE-----GDYTCEGRIMARGEIDLRVIKVIVNVLPSIRTR-------------- 214

  Fly   176 IIYTEKTHLDLMGSNIQLPCRVHARPRAEITWLNNENKEIVQGHRHRVLANG-DLLISEIKWEDM 239
              |||......:...:.|.|.....|...:.|... |.|:....::.:..:| :|.|.::...|.
Zfish   215 --YTELNATADINQAVTLACHADGYPEPTVKWARG-NTELESDEKYSLNEDGSELTIKDVNKLDE 276

  Fly   240 GNYKCIARNVVGKD----TADTFVYP 261
            |:|||||||..|:.    |.:.||.|
Zfish   277 GDYKCIARNKAGERSEEVTLNVFVQP 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	18/64 (28%)
ncam1a	XP_009293555.1	Ig	20..112	CDD:299845
		I-set	21..111	CDD:254352
		IG_like	121..200	CDD:214653	21/94 (22%)
		IGc2	128..189	CDD:197706	17/76 (22%)
		Ig	208..301	CDD:299845	26/109 (24%)
		IG_like	219..298	CDD:214653	20/79 (25%)
		Ig	300..406	CDD:299845	2/3 (67%)
		IG_like	308..406	CDD:214653
		ig	413..498	CDD:278476
		IG_like	415..498	CDD:214653
		fn3	505..589	CDD:278470
		FN3	624..715	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900