DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ImpL2 and Sdk2

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_766388.2	Gene:	Sdk2 / 237979	MGIID:	2443847	Length:	2176	Species:	Mus musculus

Alignment Length:	264	Identity:	65/264 - (24%)
Similarity:	93/264 - (35%)	Gaps:	72/264 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALLLFGSIATV-RGRAVDLVDDSNDV---DNSIEAEEEKPRNRAFEADWLKFTKTPPTKLQQADG 73
            |:|...|:|.| ||..:.:::....|   :..|.||.||
Mouse   290 AMLRSSSVAPVTRGAYLSVLEPPQFVREPERHITAEMEK-------------------------- 328

  Fly    74 ATIEIVCEMMGSQVPSIQWV-------VGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHVL 131
             .::|.|...|...|||.|.       ||.|.|.:.......|::...|.           |..:
Mouse   329 -VVDIPCRAKGVPPPSITWYKDAALVEVGKLTRFKQRSDGGLQISGLLPD-----------DTGM 381

  Fly   132 SEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSNIQLPCR 196
            .:...:...|...:.|..|.|.:.|    .:|        :.|    .:.|.:|  |.::.|.|.
Mouse   382 LQCFAHNAAGEAQTSTYLAVTSIAP----NIT--------RGP----LDSTVID--GMSVVLACE 428

  Fly   197 VHARPRAEITWLNNEN---KEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNVVGKD--TAD 256
            ....||..|||...|.   ...||..|..:|.:|.||||.....|.|.|.|:|.|..|.|  :||
Mouse   429 TSGAPRPAITWQKGERILASGSVQLPRFTLLESGSLLISPTHISDAGTYTCLATNSRGVDEASAD 493

  Fly   257 TFVY 260
            ..|:
Mouse   494 LVVW 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	24/66 (36%)
Sdk2	NP_766388.2	IG_like	44..113	CDD:214653
		IGc2	44..102	CDD:197706
		IG_like	124..207	CDD:214653
		Ig	136..192	CDD:299845
		IG_like	226..308	CDD:214653	7/17 (41%)
		IGc2	237..290	CDD:197706	65/264 (25%)
		I-set	312..401	CDD:254352	22/126 (17%)
		Ig	330..398	CDD:143165	15/78 (19%)
		I-set	406..496	CDD:254352	33/107 (31%)
		Ig	420..496	CDD:299845	28/75 (37%)
		Ig	506..590	CDD:299845
		IG_like	506..590	CDD:214653
		FN3	594..685	CDD:238020
		FN3	697..790	CDD:238020
		FN3	798..894	CDD:238020
		FN3	899..987	CDD:238020
		FN3	997..1091	CDD:238020
		FN3	1103..1198	CDD:238020
		FN3	1205..1294	CDD:238020
		FN3	1305..1398	CDD:238020
		FN3	1404..1488	CDD:238020
		FN3	1507..1620	CDD:238020
		FN3	1630..1723	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1712..1734
		FN3	1728..1809	CDD:238020
		FN3	1841..1920	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2013..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2043..2070
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2102..2176
		PDZ-binding. /evidence=ECO:0000269\|PubMed:20219992	2170..2176
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900