DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and Ptprq

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001357916.1	Gene:	Ptprq / 237523	MGIID:	1096349	Length:	2301	Species:	Mus musculus

Alignment Length:	291	Identity:	56/291 - (19%)
Similarity:	94/291 - (32%)	Gaps:	98/291 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALLLFGSIATVRGRAVDLVDDSNDVDNSIEAEEEKPRNRAFEADWLKFTKTPP--TKLQQADGAT 75
            ::::...:..|.|...|....:..:..::|:..:.|.|.      :.|.|.|.  ||.|.
Mouse  1611 SVVITAFVGNVSGAYTDGKSSAEVIITTLESVPKDPPNN------MTFQKIPDEVTKFQL----- 1664

  Fly    76 IEIVCEMMGSQVPSIQWVVGHLPRSELDDLDSNQVAEEAPSAIVRVRSSHIIDHVLSEARTYTCV 140
                     |.:|..|      |...:....:....|:.|:| |::.:..||.      :|.|.|
Mouse  1665 ---------SFLPPSQ------PNGNIQVYQALVYREDDPTA-VQIHNLSIIQ------KTDTSV 1707

  Fly   141 ---------GRTGSKTIYA--STVVHPPRSSRLTPEKTYPG--AQKPRIIYTEKTHLDLMGSNIQ 192
                     |.|.:.::||  |....|....|:|.:...|.  ..||..|:.....|.:..:.|.
Mouse  1708 IAMLEGLKGGHTYNISVYAINSAGAGPKVQMRITMDIKAPARPKTKPIPIHDATGKLLVTSTTIT 1772

  Fly   193 LPCRVHARPRAEITWLNNENKEIVQGHRHRVLANGDLLISE---------IKW------------ 236
            :        |..|.:.|::         |..:.|..:|::|         .||
Mouse  1773 I--------RMPICYYNDD---------HGPIRNVQVLVAEAGAQQDGNVTKWYDAYFNKARPYF 1820

  Fly   237 --EDMGNYKCIARN----------VVGKDTA 255
              |...|..||...          |:|.|.|
Mouse  1821 TNEGFPNPPCIEGKTKFSGNEEIYVIGADNA 1851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	15/96 (16%)
Ptprq	NP_001357916.1	FN3	57..151	CDD:238020
		FN3	308..393	CDD:238020
		fn3	399..>441	CDD:365830
		FN3	570..654	CDD:238020
		fn3	668..744	CDD:365830
		FN3	762..850	CDD:238020
		fn3	857..934	CDD:365830
		FN3	951..1049	CDD:238020
		FN3	1056..1137	CDD:238020
		FN3	1152..1233	CDD:238020
		FN3	1247..1337	CDD:238020
		FN3	1342..1421	CDD:238020
		FN3	1432..1535	CDD:238020
		FN3	1542..1638	CDD:238020	3/26 (12%)
		FN3	1645..1734	CDD:238020	26/121 (21%)
		UP_III_II	1759..1928	CDD:297589	19/110 (17%)
		R-PTPc-Q	2033..2256	CDD:350464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900