DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	223	Identity:	54/223 - (24%)
Similarity:	85/223 - (38%)	Gaps:	52/223 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FTKTPPTKLQQADGATIEIVCEMMGSQVPSIQW-----VVGHLPRSELDD--LDSNQVAEEAPSA 117
            ||:|||..::..:|.:|.:.|...|:..|.:.|     ::|...:.::.|  |....|:.|
Human   141 FTETPPQYIEAKEGGSITMTCTAFGNPKPIVTWLKEGTLLGASGKYQVSDGSLTVTSVSRE---- 201

  Fly   118 IVRVRSSHIIDHVLSEARTYTCVGRTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKT 182
                      |......|.|:..|.          .||          .|:...|.|..|.:...
Human   202 ----------DRGAYTCRAYSIQGE----------AVH----------TTHLLVQGPPFIVSPPE 236

  Fly   183 HLDL-MGSNIQLPCRVHARP-RAEITWLNNENKEIVQGH---RHRVLANGDLLISEIKWEDMGNY 242
            ::.: :..:..|.||..|.| ....||...:.....|..   |.|:|.:|.|:|..:|.||.|.|
Human   237 NITVNISQDALLTCRAEAYPGNLTYTWYWQDENVYFQNDLKLRVRILIDGTLIIFRVKPEDSGKY 301

  Fly   243 KCIARNVVGKDTAD----TFVYP--VLN 264
            .|:..|.:|:..:.    |..||  |||
Human   302 TCVPSNSLGRSPSASAYLTVQYPARVLN 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	21/67 (31%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653
		Ig	41..115	CDD:143165
		I-set	139..225	CDD:254352	23/117 (20%)
		IGc2	153..210	CDD:197706	12/70 (17%)
		I-set	229..321	CDD:254352	23/91 (25%)
		Ig	235..321	CDD:299845	22/85 (26%)
		IG_like	331..414	CDD:214653
		Ig	<353..414	CDD:299845
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900