DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and rig-4

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	313	Identity:	64/313 - (20%)
Similarity:	99/313 - (31%)	Gaps:	110/313 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VDDSNDVDNSIEAEE----------EKP-----RNRAFEADWLK---FTKTP-PTKLQQADG--- 73
            :||.:..|.|::.|.          .:|     ||......|:|   ...|| .|....:||
Worm   115 LDDFDASDESVQYEVTTGVGRYFVLRRPTLLASRNLDISYSWIKDDSHQVTPDATHFVTSDGNLV 179

  Fly    74 ---------------ATIEIVCEMMGSQV--------PSIQ-------------WVVGHLPRSEL 102
                           |:.:.:.|::..:.        ||:|             .:...||..|:
Worm   180 VTGVKRDDFGAYKLMASSDDLKEIVSKEYNVRDNGLSPSLQNTLSIVYFPTDRTIIESTLPHDEI 244

  Fly   103 DD----------------LDSNQVAEEAPSAIVRVRSSHII----------DHVLSEARTYTCVG 141
            .|                |:..|::.........:.:..:|          :|.| |.|....:|
Worm   245 FDCVTSFGSKDDVRIRWFLNGQQISGSEVGMTTTLNNRRLIISNPSSFTRGEHKL-ECRADAAMG 308

  Fly   142 RTGSKTIYASTVVHPPRSSRLTPEKTYPGAQKPRIIYTEKTHLDLMGSNIQLPCRVHARPRAEIT 206
            ||..:.....|.:..|....|..|             .:||    :||::.|.|.|..:...:|.
Worm   309 RTSDQKSAYMTFISRPILKDLPNE-------------IQKT----VGSSLSLKCSVKKKSSMDIK 356

  Fly   207 WLNNENKEIVQGHRHRVLANGDLLISEIKWEDMGNYKCIARNVVGKDTADTFV 259
            |..|......|        .|.|.|..||.:|.|.|:|.|.|..|.|.|..:|
Worm   357 WYKNGLMMTTQ--------RGKLTIDRIKQDDFGLYQCEATNAAGADLASVWV 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	20/63 (32%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	27/97 (28%)
		IGc2	338..393	CDD:197706	20/62 (32%)
		I-set	459..543	CDD:254352
		IGc2	478..534	CDD:197706
		IG_like	553..639	CDD:214653
		Ig	564..635	CDD:143165
		FN3	643..747	CDD:238020
		FN3	756..850	CDD:238020
		FN3	858..954	CDD:238020
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810