DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ImpL2 and lrit3b

DIOPT Version :9

Sequence 1:	NP_728961.2	Gene:	ImpL2 / 38513	FlyBaseID:	FBgn0001257	Length:	267	Species:	Drosophila melanogaster
Sequence 2:	XP_009305418.1	Gene:	lrit3b / 100144406	ZFINID:	ZDB-GENE-070424-130	Length:	487	Species:	Danio rerio

Alignment Length:	221	Identity:	45/221 - (20%)
Similarity:	78/221 - (35%)	Gaps:	72/221 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 FTKTPPTKLQQADGATIEIVCEMMGSQVPSIQWV---------VGHLPRSELDDLDSNQ------ 109
            :..|..||:....|:|:.:.||..|...|::.|:         .|...::: ..||:.:
Zfish   280 YVVTSATKITALLGSTVLLRCEATGHPTPALMWIKSAKRNLYNQGCCKQTQ-SSLDTERFPKKLF 343

  Fly   110 -VAEEAPSAIVR--VRSSHIIDHVLSEARTYTCVGRTG---SKTIYASTVV-------------- 154
             ..:|:|...||  |.|.:.|.:  |:|..|.|..:..   |:.:.:..||
Zfish   344 GYVQESPRVGVRWSVVSLNGISY--SDAGEYRCRAQNMAGISEAVVSLNVVGVMAEYTDFKNSDQ 406

  Fly   155 ------------HPPRSSRLTPEKTYPGAQKP--RIIYTEKTHLDLMGSNIQLPCRVHARPRAEI 205
                        .|.:.|:....:...|:..|  |::.|.|...|.|           .|.|..:
Zfish   407 QQTTTKSDSKRTKPKQKSKAMMPRNMTGSLSPLKRVLKTPKAGRDKM-----------KRDRTAV 460

  Fly   206 TWLNNENKEIVQGHRHRVLANGDLLI 231
            ..|:         |||.:.|:.|.|:
Zfish   461 QKLS---------HRHFLTASDDSLL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ImpL2	NP_728961.2	IGc2	187..251	CDD:197706	10/45 (22%)
lrit3b	XP_009305418.1	LRRNT	51..92	CDD:214470
		leucine-rich repeat	69..89	CDD:275380
		LRR_8	112..172	CDD:290566
		leucine-rich repeat	114..137	CDD:275378
		leucine-rich repeat	138..161	CDD:275378
		LRR_8	160..214	CDD:290566
		LRR_4	160..201	CDD:289563
		leucine-rich repeat	162..185	CDD:275378
		leucine-rich repeat	186..199	CDD:275378
		leucine-rich repeat	215..230	CDD:275378
		Ig	278..391	CDD:299845	25/113 (22%)
		I-set	279..391	CDD:254352	25/113 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900