DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT4 and krt7

DIOPT Version :9

Sequence 1:	NP_002263.3	Gene:	KRT4 / 3851	HGNCID:	6441	Length:	520	Species:	Homo sapiens
Sequence 2:	XP_002935788.2	Gene:	krt7 / 100101751	XenbaseID:	XB-GENE-876869	Length:	523	Species:	Xenopus tropicalis

Alignment Length:	535	Identity:	320/535 - (59%)
Similarity:	389/535 - (72%)	Gaps:	55/535 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    15 FSCGSAIVGGGKRGAFSSV------SMSGGAGRCSSGG-FGSRSLYNLRG--NKSISMSVAGSRQ 70
            ||..||:    ...:||.:      |.|||||...:|| |.|.||.|:.|  .||:|..|:..|.
Frog    11 FSTRSAV----PAASFSQMRISSTRSSSGGAGLGRAGGSFSSSSLSNIGGGVRKSVSYGVSSGRS 71

Human    71 -GACFGGAGGFGTGGFGG-GFGGSFSGKG----GPGFPVCPAGGIQEVTINQSLLTPLHVEIDPE 129
             ||.|||| |||..|||| ||||:..|.|    ||        ||||||||||||.||::||||.
Frog    72 GGAGFGGA-GFGGAGFGGAGFGGAGFGGGVAYSGP--------GIQEVTINQSLLAPLNLEIDPT 127

Human   130 IQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSV 194
            ||.||.|||||||.||||||||||||:|||||||||||||.|||.|.:..:| |:.|||:.|::.
Frog   128 IQHVRQEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQNQKSAKAS-NVGPLFDAYIAN 191

Human   195 LRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELE 259
            ||:|||.|..|||:|:.||:.|||.|||||.|||:||||||:|||:||||||||||||:||||||
Frog   192 LRRQLDGLTGDKGKLEGELRNMQDLVEDFKNKYEDEINKRTSAENEFVVLKKDVDAAYMNKVELE 256

Human   260 AKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKA 324
            ||:::|.||||||:.||:|||.::|..:|||||||||||||.||:|||||||:||||:||.:|:|
Frog   257 AKMEALTDEINFLRALYEAELRELQEQISDTSVVLSMDNNRALDMDSIIAEVKAQYEDIANKSRA 321

Human   325 EAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQR 389
            .|||:||.|.|:||.:..:|||:|:.||:||:||||.:|||:||||::|.|...|:..:|:||:|
Frog   322 NAEAVYQNKFQELQATAGRHGDDLRTTKTEISELNRAMQRLQAEIESVKAQRAKLEAQIAEAEER 386

Human   390 GENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGEC 454
            ||.|||||.:|..|||||||:||:::||.||||||||:||||||||||||||||||||.|:| |.
Frog   387 GELALKDARTKLAELEAALQKAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEETRIS-EG 450

Human   455 QSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVS--------------GS 505
            ...||:|||:.::|:.|           |.|||:|:|.|||||.|||.|              ||
Frog   451 PGPVSVSVVNSTSSSMG-----------GSSSGYGAGYGSGFGAGGSFSSGGFGSSSTKFGSGGS 504

Human   506 SSSKIISTTTLNKRR 520
            |..|..|.||.:..|
Frog   505 SGVKSYSVTTSSSSR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT4	NP_002263.3	Head	1..136		68/135 (50%)
		Keratin_2_head	14..133	CDD:406589	66/132 (50%)
		Filament	136..449	CDD:365827	219/312 (70%)
		Coil 1A	137..172		31/34 (91%)
		Linker 1	173..191		7/17 (41%)
		Coil 1B	192..284		64/91 (70%)
		Linker 12	285..307		16/21 (76%)
		Coil 2	308..447		92/138 (67%)
		Tail	448..520		32/85 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..520		10/33 (30%)
krt7	XP_002935788.2	Keratin_2_head	<106..131	CDD:374433	20/24 (83%)
krt7	XP_002935788.2	Filament	134..446	CDD:365827	219/312 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D265795at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X62
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020