DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG43367 and LRBA

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_005263429.1 Gene:LRBA / 987 HGNCID:1742 Length:2868 Species:Homo sapiens


Alignment Length:3072 Identity:681/3072 - (22%)
Similarity:1066/3072 - (34%) Gaps:1108/3072 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   447 LFTSLQEYGS-PTVELLDTCFML----GYDESEHFLLLPEVMLRLLNWVPTLQEREQLHVTSLVL 506
            :.|.|.|.|. ...::::|.|.|    .:|...:|:               :||.|.::....:|
Human    50 VLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFI---------------IQEGESINCMVDLL 99

  Fly   507 KGCTDNYRTKTVACGSHIIK------AVCGCLLTAESLAENC------VQN-----LIKLIEELS 554
            :.|....:.:..:..:.|:|      .||    |...|.|..      |.|     |:.::..|:
Human   100 EKCDITCQAEVWSMFTAILKKSIRNLQVC----TEVGLVEKVLGKIEKVDNMIADLLVDMLGVLA 160

  Fly   555 KLSIVPAELKCIFSLLRQGTK--FPQ--------FKQLQQTLVVIALQSLRGSNSCAEFFSIEQP 609
            ..::...|||..||.| ||.|  :|.        .|.:.|.....|..:..|.::.|        
Human   161 SYNLTVRELKLFFSKL-QGDKGRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAA-------- 216

  Fly   610 TDGILVPDIRNWTISGSYGFIFHILVRFNQLK--EQSNSRRMLLTLQTASGSGFEV-FVQPNGNV 671
               |.:|.|..|....  ||.||..:|.:.:.  .....:..|...:|:.|.|:.. ||  .|.:
Human   217 ---IALPPIAKWPYQN--GFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV--GGCL 274

  Fly   672 VVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPK----------RPFSYSQINIYVDFVQKLS 726
            :|            |:.|:...|..|.:.....|.|          ..:..|::..||:      
Human   275 IV------------TSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVN------ 321

  Fly   727 ATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVS 791
                                      ||:|..|.:                              
Human   322 --------------------------GELASYGEI------------------------------ 330

  Fly   792 NYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQT-CLNGHLGGVLL---ADPTTSLKTIFDAGANF 852
               |..:.|...||   |.| :|..:|....:. |  |.:..|.|   |.....:..|:..|..:
Human   331 ---TWFVNTSDTFD---KCF-LGSSETADANRVFC--GQMTAVYLFSEALNAAQIFAIYQLGLGY 386

  Fly   853 SSI--FSQDNDLL------------ELNSRFVFCYAPGAIWHGTCQDLIPGGK------YPGRIN 897
            ...  |..::||.            :|:|...|.|.|.|.....|.:..|...      .|..:.
Human   387 KGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALM 451

  Fly   898 AQHCKIV---KIQETINSIGGISAILPMLHRL---ITLDQTTDISIGSVSEESLSCAPTPSAEEF 956
            .|..|.|   .||..::||||:..:.|:..:|   ..|....|::|.|                 
Human   452 LQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICS----------------- 499

  Fly   957 TDWEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFD- 1020
                                  :.|..:..|.......|||:|:.:...::|..|::...|... 
Human   500 ----------------------TLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSR 542

  Fly  1021 --VNALMATHLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDR 1083
              :...:|....:.:||.     |..||..|..|::.:.|||.....::.|....|||.......
Human   543 AVLELCLAFSKYLSNLQN-----GMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTV 602

  Fly  1084 KFFR--KRYG-VQFVLDVVRQYY----------STPDSI-----SDDDAKTIRATLFGIIKFYLQ 1130
            ..:.  :|.| |..::..::.||          .||..:     :..:..::||.|...||..:.
Human   603 NIYNTIRRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVM 667

  Fly  1131 KDVNIK--EVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVD 1193
            ||..:|  |:.:::.:|.::.:|..|::.|:::...:  ....:.|:....:.....::|.....
Human   668 KDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALM--SEHPNSMIPAFDQRNGLRVIYKLLAS 730

  Fly  1194 KSYSNEIQE-AAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSST----- 1252
            ||....:|. .|:.:....||..|              ..|..:..|.||.:....:..|     
Human   731 KSEGIRVQALKAMGYFLKHLAPKR--------------KAEVMLGHGLFSLLAERLMLQTNLITM 781

  Fly  1253 ----ILFHLVDEMLGLQ--------PD-------------------------------------- 1267
                :||.::.|.:|.|        ||                                      
Human   782 TTYNVLFEILIEQIGTQVIHKQHPDPDSSVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDM 846

  Fly  1268 --------------------------------------------YAGLIFLVYH----------- 1277
                                                        ||....|:||           
Human   847 IKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRV 911

  Fly  1278 ----VSSCDLPVKLEIAKRLLQTTFVKQQSTV----AMAKQTGWQESIARLLIRKPIT----SSP 1330
                :|.....|..||.|..|...|.:||..|    .:...|..|.:..   ||:.|.    |..
Human   912 WVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASG---IRRDINVSVGSQQ 973

  Fly  1331 PDEEK-----------RRSFGINLDVLLEDNSNFLAQADLITFSEQEIGLAQLQQQQQEELSDSG 1384
            ||.:.           ..:..|.....||..||...|....::.|.:      .:|:.:||.|.|
Human   974 PDTKDSPVCPHFTTNGNENSSIEKTSSLESASNIELQTTNTSYEEMK------AEQENQELPDEG 1032

  Fly  1385 ----------------------------------------LILNEIQASVTEAATVIESEIKELA 1409
                                                    :.::|:.||::..:....||:.|..
Human  1033 TLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTASISSPSEEDASEMPEFL 1097

  Fly  1410 E---------------SVSGAVVENAN---------------------SLFS------------- 1425
            :               .|.|:..|.||                     .:|.             
Human  1098 DKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPV 1162

  Fly  1426 VIRQTTHDLQDTFESLTQGSSTDTADGSQTPS--------------------------IQREESL 1464
            ..:||..:.||:.:|   |..|.||.||...|                          :.||..|
Human  1163 TEKQTDTETQDSKDS---GIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKL 1224

  Fly  1465 SSDTSSQSPHGPPKKSDSLESTSAFDFVADGDVDTEEQLVYLVSNTLFNIFWRGIPN-------- 1521
            .:|.     ||...::.|.:..:..| |::...|||            .:..:..||        
Human  1225 INDC-----HGSVSEASSEQKIAKLD-VSNVATDTE------------RLELKASPNVEAPQPHR 1271

  Fly  1522 -------DHPQCWQ-------------ERGQVLGC--INLLALNNELITSHLSLRLRILEMAVQA 1564
                   .|.|..|             .|..|...  .|...::..|:|.        |..:::.
Human  1272 HVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTD--------LLFSIET 1328

  Fly  1565 SLFDLSEHGSQTLVNQENAS----------HILRMVYELVVL--------------GSNEDE--- 1602
            .:.....|.::|:::..|:|          |::..|.:.:|:              .::|.|   
Human  1329 DIQMWRSHSTKTVMDFVNSSDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIE 1393

  Fly  1603 -----SKKCSTKLLDGVLALLDALMI--------FQQGSSDDWSDMIRLCLGLL--------LKC 1646
                 |.:.|...|..:::|:|.|:.        .:...|.....::|.||.|:        |:|
Human  1394 PTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGILRQCLRLVCAVAVRNCLEC 1458

  Fly  1647 SHH------------PNPGIVAM--ATAK---------------LHAILQS-----------RST 1671
            ..|            |...::.:  :.||               |..:||.           |..
Human  1459 QQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDI 1523

  Fly  1672 EDPAELSYLLYSI--------------------NRALDNAIEVGN-----------PEEYSFL-- 1703
            ||..:..:|..::                    .|...:..|.|:           |..:|.|  
Human  1524 EDSKQAQFLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTT 1588

  Fly  1704 ----------------------------------------------------------------- 1703
                                                                             
Human  1589 ASVEESESTSSARRRDSGIGEETATGLGSHVEVTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPE 1653

  Fly  1704 ---------------------------------------MPVMKALL------------------ 1711
                                                   :.|..|||                  
Human  1654 TKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGDLSVEQPVQ 1718

  Fly  1712 ------------EKCRVA---FN-------------LDST------------------LPDLP-- 1728
                        :|..|:   ||             :||.                  ||.:|  
Human  1719 FRSFDRSVIVAAKKSAVSPSTFNTSIPTNAVSVVSSVDSAQASDMGGESPGSRSSNAKLPSVPTV 1783

  Fly  1729 -STSSGPV----------------------FFNDFQ----------------------------- 1741
             |.|..||                      .|.||.                             
Human  1784 DSVSQDPVSNMSITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSS 1848

  Fly  1742 ------MYSTSKKWRNFIER--------MVKP--LYDRYQRDIELHLWEPINRFWAECYEACKAA 1790
                  |...|::|:|.|::        :|..  |..:..:|   ||....|       ||....
Human  1849 SVVELVMLLCSQEWQNSIQKNAGLAFIELVNEGRLLSQTMKD---HLVRVAN-------EAEFIL 1903

  Fly  1791 SKQRATN---QAENRRLFQQKIYMPWKVRQVEEM--QRLQAAALQ-HKTIDSHIRKRWKTAKRFL 1849
            |:|||.:   .||...|..|  |...| |:.|:|  ..::||..: |.|....|:|    ....|
Human  1904 SRQRAEDIHRHAEFESLCAQ--YSADK-REDEKMCDHLIRAAKYRDHVTATQLIQK----IINIL 1961

  Fly  1850 YGPRGPWYTGEVDE--EFWKLSQHENVARMRLKLEPQLYPNKHENAA-----------NLRDNAT 1901
            ....|.|....|..  |||:|...|:..|.|.:.......:.|..|.           .||:| :
Human  1962 TDKHGAWGNSAVSRPLEFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHVCIFKLREN-S 2025

  Fly  1902 SAYDTKEISEFDSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQQDVA-LEKLV----MSQDCE 1961
            .|.|...:::...:|::..:     .:::|:.|..|....||.:..|.. ||.|.    :|...:
Human  2026 KATDEDILAKGKQSIRSQAL-----GNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLSTPAQ 2085

  Fly  1962 LITLMTKVKGRIEVNQSVFTF-VDLSPPT-----------EDGSKYDFRFSTNKIREVHLRKYNL 2014
            |:.....|||.:.|..|...| ||...|.           .:|....:.|:  :||.:..|:|.|
Human  2086 LVAPSVVVKGTLSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFT--EIRSIFSRRYLL 2148

  Fly  2015 RRSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGLPLPNILYGSG-----------RSPAELLRAS 2068
            :.:|||||:.::.:...||......|   |:|.. ||.:..|:.           .||.:|.:||
Human  2149 QNTALEIFMANRVAVMFNFPDPATVK---KVVNY-LPRVGVGTSFGLPQTRRISLASPRQLFKAS 2209

  Fly  2069 GLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIG 2133
            .:||||.:||||||||||:||||||||||||:|||||||::.:|.|:.||||.|.:|||||||||
Human  2210 NMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPTNFRDLSKPIG 2274

  Fly  2134 CINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVAD 2198
            .:|||..|....:|:|:||..  :||||||||||.::.||.:|||:||||:..::||.|:||.||
Human  2275 ALNPKRAAFFAERYESWEDDQ--VPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHAD 2337

  Fly  2199 RQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTPE 2263
            |.|.||.:.|:....:.:|:|||||||:|.||...|.|.::||.:. ....|.||.||.||.|.|
Human  2338 RTFSSISRAWRNSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMD-DGTVVSDVELPPWAKTSE 2401

  Fly  2264 EFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREA 2328
            ||:.|:|.|||||:||..||.||||||||||:||:|..|||||||.:|||||:|:.||:||.|||
Human  2402 EFVHINRLALESEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREA 2466

  Fly  2329 VEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIV 2393
            ||..|.:|||.|||||.||||.|.:..:..| |:::.|      .|.||..|         |.|:
Human  2467 VEAQIRSFGQTPSQLLIEPHPPRGSAMQVYL-LLQSPL------MFTDKAQQ---------DVIM 2515

  Fly  2394 YLSPPRSPPRSFLQ------LSPDVLVSISKSTILGCNSWLSFDKDQGFL--------LEIDATT 2444
            .|..|.:.|.:.:.      |:...:::::.:.:...|.|.:....||.:        :|||...
Human  2516 VLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLI 2580

  Fly  2445 ANL--KNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDI 2507
            |:.  .:|::|......|.|.|||.|.:::|.:.:...|.||.|.|||:.:.|:.:..|..|.|:
Human  2581 ASNTGMHRRQITDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDV 2645

  Fly  2508 ITCIALD------NCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNT 2566
            :||:|..      ||  |:::||||.|.::|.......|.|                      :.
Human  2646 VTCLARSESYIGGNC--YILSGSRDATLLLWYWNGKCSGIG----------------------DN 2686

  Fly  2567 QNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQ 2631
            ..|.:..|..:|.|||..::..|:..||.||:|||.:|...:::: .|..:|||:.   .|:|::
Human  2687 PGSETAAPRAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSM-NGDLLRTLEG---PENCLK 2747

  Fly  2632 ISFVTLSYHGHIAF---SALDDTSHSVHVYSINGCSLGSKYVSGRVTGLASASD--YLVVADDAG 2691
            ...:..|..||...   :.|..|      :|:||....:......:..:..:.|  ||:...|.|
Human  2748 PKLIQASREGHCVIFYENGLFCT------FSVNGKLQATMETDDNIRAIQLSRDGQYLLTGGDRG 2806

  Fly  2692 DITMSRLHGLKPVFDIP 2708
            .:.:.::..||.:|..|
Human  2807 VVVVRQVSDLKQLFAYP 2823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 17/119 (14%)
DUF4704 906..1162 CDD:292415 56/281 (20%)
DUF4800 1650..1899 CDD:292675 83/566 (15%)
PH_BEACH 1952..2046 CDD:275391 29/109 (27%)
Beach 2072..2351 CDD:280327 172/278 (62%)
WD40 <2428..2734 CDD:225201 78/302 (26%)
WD40 repeat 2465..2503 CDD:293791 13/37 (35%)
WD40 2468..2687 CDD:295369 59/229 (26%)
WD40 repeat 2509..2580 CDD:293791 17/76 (22%)
WD40 repeat 2585..2621 CDD:293791 12/35 (34%)
LRBAXP_005263429.1 LamG 229..376 CDD:304605 39/233 (17%)
DUF4704 446..717 CDD:292415 61/316 (19%)
DUF1088 1880..2058 CDD:284000 48/200 (24%)
PH_BEACH 2084..2181 CDD:291510 27/102 (26%)
Beach 2213..2489 CDD:280327 172/278 (62%)
WD40 <2595..2862 CDD:225201 70/263 (27%)
WD40 repeat 2605..2641 CDD:293791 11/35 (31%)
WD40 <2610..2850 CDD:295369 64/248 (26%)
WD40 repeat 2647..2700 CDD:293791 17/76 (22%)
WD40 repeat 2705..2740 CDD:293791 12/35 (34%)
WD40 repeat 2745..2774 CDD:293791 7/34 (21%)
WD40 repeat 2787..2821 CDD:293791 7/33 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1787
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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