DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and Lyst

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_038952047.1 Gene:Lyst / 85419 RGDID:621837 Length:3840 Species:Rattus norvegicus


Alignment Length:3321 Identity:712/3321 - (21%)
Similarity:1165/3321 - (35%) Gaps:1115/3321 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 LEEQAIEEVAI-LVDCLVIVCRHFDNILSIIKYEYKPNLIAILSRVFKQQMELPQSVPAISHLFS 152
            |...::|.|.: ..:||    .|..:|.|:.::.|      :|:.||::|.          |...
  Rat   940 LPRLSLENVVLPSPECL----HHAADIWSMCRWIY------MLNSVFQKQF----------HRLG 984

  Fly   153 SFSAFLEVMYDPYLTWRSFVRGQSADYSRLSYKPHSVHVEIVPFIYDCFQEEKLIRYAEIGESLL 217
            .|....|::   ::..:...|..:.|..|..                             ||..:
  Rat   985 GFQVCHELI---FMIIQKLFRSHTEDQGRRQ-----------------------------GEMSV 1017

  Fly   218 NILGAVICGSQLQLKVQKSLNSTST-------LTNRNTNALTTSSLAPCSGDGLLDCDNLRNGMK 275
            |....::..||.::.:::.::|::.       .:....:.|.:..:.|.|.:.:|          
  Rat  1018 NKNQGLMRISQPEMILKEDVSSSTAPEPGFLKKSADRVSELESQHMLPTSAEQIL---------- 1072

  Fly   276 AICPATVSI---TMSILRQWESANNLRRVALQCYALMVIVLQKSSPEERQIDL------VTLVQL 331
                ||.||   ..:.:.| ||...|:.:.| ..:|:.|.|..:...:::::|      ::|..:
  Rat  1073 ----ATKSIPGEAKTFMNQ-ESETCLQSIRL-LESLLAICLHSARASQQKMELELPSQSLSLENI 1131

  Fly   332 YCDALQELLATKHFDSGDAN--FDITSDADQDVAIDMAALSSTVAAVKFFVTGDAGVSEAVSDSN 394
            .|:....|..:|..::..|.  ||         |:...||.:..|.:.   .||. |:|....|.
  Rat  1132 LCELRDHLSQSKVAETELAKPLFD---------ALLRVALGNHSADLD---PGDT-VTEKSHPSE 1183

  Fly   395 LLELLTNLPKLIKPWHISHSS--SLCSTMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSP 457
              |||:      :|...|..:  |.|..::.|.....:...|.|....||        .|:.|  
  Rat  1184 --ELLS------QPGDFSEETEDSQCCNLKLLGEEEGYEADSESNPEDGE--------TQDDG-- 1230

  Fly   458 TVELLDTCFMLGYDESEHF--LLLPEVMLRLLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVAC 520
             |||         .|:|.|  .::|..:|..|.           |                    
  Rat  1231 -VEL---------PEAEGFSGSIVPNNLLESLT-----------H-------------------- 1254

  Fly   521 GSHIIKAVC--GCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLRQGT--------- 574
            |..|...:|  |..|.:.|.|:  :..|..:.|  |.|.|...:.|.|..|::|||         
  Rat  1255 GEIIYPEICILGLNLLSGSKAK--LDVLAHVFE--SFLKIARQKEKNISLLMQQGTVKILLGGFL 1315

  Fly   575 -----KFPQFKQLQQTLV--VIALQSLRGSNS----CAEFFSIEQPTDGILVPDIR-----NWTI 623
                 ....|:..|:.||  :::|.|.|.|:.    ....|..:.|...||:..|:     ::|:
  Rat  1316 NVLTQTNSDFQACQRVLVDLLVSLMSSRMSSEDLTLLLRIFLEKSPCTEILLHGIQKIVESDFTM 1380

  Fly   624 SGSYGFIFHIL----------------------------VRFNQLKEQSNSR----RMLLTLQTA 656
            |.|....|.:|                            .|.::.|::::..    |:|.:...|
  Rat  1381 SPSQYLTFPLLHTPSLSNGVSSQKPPGILNSKALGLLRRARISRGKKEADRESFPYRLLSSWYIA 1445

  Fly   657 S--------------GSGFEVFVQPNGNVV---VAALTRREYLTSSTATKTLMD-------GQWH 697
            .              ..||.|.:..|...:   .:|..|.:.:........|.|       |...
  Rat  1446 PIHLPLLGQNCWPHLSEGFSVSLWFNVEYIHESESAAERGKKVKKRNKPSVLEDSSFERAEGDRP 1510

  Fly   698 YLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEP------FTVCSIGAVVAPPQPGEVA 756
            .:|.:|:|..|......|::    :...|..|.:|...:|      |.||        ....:..
  Rat  1511 EVTESISPSDRLIEDGCIHL----ISLGSKALMIQVWADPHSGTFIFRVC--------VDSNDDM 1563

  Fly   757 KTGNMPRSSSQES-------------------GSSGYKGMLPSLLERTLSANVSNYFTLPMRTQT 802
            |...:.:..|||:                   |.....|.:...:......:|...|.||.:|..
  Rat  1564 KAVTLAQVESQENIFFPSSWQHLILTYIQHPQGKKNVHGEISIWVSGQRKTDVILDFVLPRKTSL 1628

  Fly   803 AFDPNVKNFPIGMQDTVFGEQTCLNGH----------------LGGVLLAD----PTTSLKTIFD 847
            :.|.| |.|             |:.||                ||.:||.:    .:.....::.
  Rat  1629 SSDSN-KTF-------------CMIGHCLTSQEEFLQLAGKWDLGNLLLFNGAKIGSQEAFYLYA 1679

  Fly   848 AGANFSSI-----------FSQ--DNDLL---ELNSRFV--------------------FCYAPG 876
            .|.|::||           :|:  :.::|   |:...|:                    :|.|..
  Rat  1680 CGPNYTSIMPCKYGKPVVDYSKYINKEILRCDEIRDLFMTKKDVDVGLLIESLSVVYTTYCPAQY 1744

  Fly   877 AIWHGTCQDLIPGGKYPGRINAQ---------------------------HCKIVKIQETINSIG 914
            .|:.       |..:..|::..|                           .||  .||..::.||
  Rat  1745 TIYE-------PVIRLKGQVKTQLSQRPFSSKEAQSILLEPSQLKSLQPTECK--TIQGILHEIG 1800

  Fly   915 GISAILPMLHRLITL---DQTTDISI--------------------------------------- 937
            |....:.:..|::.|   ::|..:::                                       
  Rat  1801 GAGIFVFLFARVVELSSCEETQALALRIILSLIKYSQQRTHELENCNGLSMIHQVLVKQKCVVGF 1865

  Fly   938 --------GSVSEESL-------------SCAPTPSA----EEFTDWEMLSSNSYTEWKMLQHPL 977
                    |...||.:             |.|.....    |...||::.:......|:.|   |
  Rat  1866 HILKTLLEGCCGEEVIFVNEHGEFKLDVESHAIIQDVKLLQELLLDWKIWNKAEQGVWETL---L 1927

  Fly   978 ASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALMATHLLM--ESLQGHK-- 1038
            |:...|:|....:.:.|..|||                      ||.:..|.|:  :.||.|:  
  Rat  1928 AALEVLIRVEHQQQQFNITQLL----------------------NARVVHHFLLTCQVLQEHREG 1970

  Fly  1039 -----------------AEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQ---YLSAMIKNDR 1083
                             ||..|...|.....::|:|.:.........:.|..   |.|..|  |.
  Rat  1971 QLTSMPREVCRSFVKIIAEVLGSPPDLELLSVIFNFLLAVHPPTNTYVCHNPANFYFSLHI--DG 2033

  Fly  1084 KFFRKRY------------GVQF------VLDVVRQYYSTPDSISDDD-------AKTIRA---- 1119
            |.|.::.            |..|      |:.......|.|:..|..:       |:.:|:    
  Rat  2034 KIFHEKVRSIMYLRHSSSGGQSFPSPGFMVISPSAFTASPPEGTSSSNIVPQRMAAQMVRSRSLP 2098

  Fly  1120 ------------TLFGIIKFYLQKDVNIKE--------VNSMITFLASVRQDVVLVEFLEMMTFY 1164
                        .|.|.:.|.:.|..||.:        :.|..|...|..:..:           
  Rat  2099 AFPTYSPLMQAQKLAGSLVFSVDKLQNIADASPEKRNPLGSPYTLKKSKEEAFI----------- 2152

  Fly  1165 VRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQEAAIRF---------------------- 1207
               .:|:....:...|.        |...::.:|.:...::||                      
  Rat  2153 ---SSCESAKTVCEMEA--------FLAAQASANGVSRGSLRFPMARIDHKDLGTEHRSDDDSPG 2206

  Fly  1208 ----------ISGLLATSRVHQKYKQVLRL----------------------------------- 1227
                      :.||.:..|.|..... |.|                                   
  Rat  2207 DESYPRRPDNLKGLASFQRSHSTIAS-LGLAFPSQNGSAVASRWPSLVDRNADDWENFTFSPAYE 2270

  Fly  1228 --YDQTT------EQSMFP---GFFSFITPLSLSSTILFHLVDEMLG------LQPDYAGLIFLV 1275
              |::.|      |..:.|   ||:      .|.|.:|..|.|.||.      :|.|.  |:.||
  Rat  2271 ANYNRATSTHSAIEDCLIPICCGFY------ELLSGVLLVLPDAMLEDVMDRIIQADI--LLVLV 2327

  Fly  1276 YHVSSCDLPVKLEIAKRLLQT-----------TFVKQQSTVAMAKQ----TGWQESI---ARLLI 1322
            .|.|    |...:...:|||.           .|:|.:....:|.|    .|.||.:   ..:..
  Rat  2328 NHPS----PAIQQGVIKLLQAYINRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFIEMFF 2388

  Fly  1323 RKPITSSPP---DEEKRRSFGINLDV-----LLEDN--SNFLAQADLITFSEQEIGLAQLQQQQQ 1377
            .:|......   ||.|.........|     |:|.:  .|.|....|:..    :.:.....:..
  Rat  2389 GRPFGLDEEFDLDEMKHMELFQKWSVIPILGLIETSLYDNILLHNSLLLL----LQVLNSCSKVA 2449

  Fly  1378 EELSDSGLI---------LNEIQASV-TEAATVIESEIKEL-------AESVSGA----VVENAN 1421
            :.|.|:||:         ||.::.:: .....::..:|::|       |.|.||:    |:|:..
  Rat  2450 DMLLDNGLLYVLCNTVAALNGLEKNIPLNEFRLLACDIQQLFIAVTIHACSSSGSQYFRVIEDLI 2514

  Fly  1422 SLFSVIRQTTHD-------------LQDTFESLTQGSSTDT---ADGSQTPSI------QREESL 1464
            .|...:..:.:.             ||...|.:...::.|:   .|..|:||.      |:..|:
  Rat  2515 VLLGYLHNSKNKRTQNMALALQLKVLQAALEFIRSTANHDSESPLDAVQSPSAYHHSVPQKRRSI 2579

  Fly  1465 SSD---TSSQSPHGP----------------PKKSDSLESTSA--------------FDFVADGD 1496
            :..   ..|.:||.|                |...||.:.:..              |..     
  Rat  2580 AGSIPVKGSVTPHLPRRHFGSYGQLPMPFFSPLNQDSPQLSPGCTTCVVPPRAGPRKFPL----- 2639

  Fly  1497 VDTEEQLVYL---VSNTLFNIFWRGIPNDHPQ--CWQERGQVLGCINLLALNNELITSHLSLRLR 1556
            ..||..|:.:   .|:.|.::..|.:..:||.  ...|..|.|..:.:||:|            |
  Rat  2640 AQTESLLMKMRSVASDELHSMMQRRMSQEHPSQASEAELAQRLQRLIILAVN------------R 2692

  Fly  1557 ILEMAVQASLFDL---SEHGSQ--TLVNQENAS----HILRMVYELVVLGSNEDESKKCSTKLLD 1612
            |:...:.:.:.|:   .|:.||  |.|:|...|    |     ||...: ||..: |:..|.|||
  Rat  2693 IIYQELNSDIIDILRTPENTSQSKTSVSQTETSEEDVH-----YEQPSV-SNPFQ-KEMFTYLLD 2750

  Fly  1613 GVLALLDALMIFQQGSS-DDWS-------DMIRLCLGLLLKCSHHPNPGIVAMATAKLHAILQSR 1669
            |....:.:   .:.|:| ..|:       :.:|:.||.||  :|..:|........::..|:...
  Rat  2751 GFKISIGS---SKTGTSKQQWTKILGSSKETLRVQLGRLL--AHILSPTHTVQERKQILEIVHEP 2810

  Fly  1670 STED---------PAELSYLLYSINRALDNAIEVGNPEEY---SFLMPVMKALLEKCRVAFNLDS 1722
            :.:|         |...:.|:..::..:.|..:..|.||.   ..||..:|....||        
  Rat  2811 AHQDILRDCLSPSPQHGAKLVLYLSELIHNHQDELNEEEMDTAELLMNALKLCGHKC-------- 2867

  Fly  1723 TLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQRDIELHLWEPINRFWAECYEAC 1787
             :|  ||..|.|...                 :::|....:|..:      |.::          
  Rat  2868 -IP--PSAPSKPELI-----------------KIIKEEQKKYDSE------ESVS---------- 2896

  Fly  1788 KAASKQRATNQAENRRLFQQKIYMPWKVRQVEEMQR--LQAAA----LQHKTIDSHIR------- 1839
            |.|.::..:|..::  |||:   :..|.:.:.::..  .||.:    |:.|.:..|||       
  Rat  2897 KVAWQKTVSNNQQS--LFQR---LDLKSKDISKIAADITQAVSLSQGLERKKVIQHIRGMYKVDL 2956

  Fly  1840 ---KRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKLEPQLY---PNKHENAANLRD 1898
               :.|:...:.|...|..||........|:|...|...|.|.:|: :.|   |||:    .|||
  Rat  2957 SASRHWQELIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQ-RCYLTIPNKY----LLRD 3016

  Fly  1899 NATS----------AYDTKEISEFDSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQQDVALEK 1953
            ...|          .::.|..|.|.||:|:.      |..||.::.   |:.|.....::.|.|.
  Rat  3017 RQKSEGVLKPPLSYLFEDKTHSSFSSTVKDK------AASESIRVN---RRCISVAPSRETAGEL 3072

  Fly  1954 LVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYDFRFSTNKIREVHLRKYNLRRSA 2018
            |:  ..|.:..:.......:|.:       .|....|..|   |.::..:|:|:|.|.:.||.:|
  Rat  3073 LL--GKCGMYFVEDNASDTVESS-------SLQGELEPAS---FSWTYEEIKEIHRRWWQLRDNA 3125

  Fly  2019 LEIFLVDQTSYFLNF-TTKTRNKVFTKIVGLPLPNIL-YGSGRSPAELLRASGLTQRWINREISN 2081
            :||||.:..:..|.| .||.|:.|:..|:...||::| ||:         .:.||..|...:|:|
  Rat  3126 VEIFLTNGRTLLLAFDNTKVRDDVYQSILTNNLPSLLEYGN---------ITALTNLWYTGQITN 3181

  Fly  2082 FEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGK 2146
            ||||.:||..||||:|||.||||||:||:||.|:.|||.||..:|:|||||.....:.|......
  Rat  3182 FEYLTHLNKHAGRSFNDLMQYPVFPFILSDYVSETLDLNDPSIYRNLSKPIAVQYKEKEDRYVDT 3246

  Fly  2147 YDSFE----------DPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQF 2201
            |...|          ||...:..:|||:|||||..|||:|:|:.|||.:.:..|...||:.||.|
  Rat  3247 YKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTF 3311

  Fly  2202 HSIPQTWKL-LMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWA-TTPEE 2264
            ||...||:| ..::..|||||||||||.||||.|...||.|..| ..|:|:.|.||.|| ..|..
  Rat  3312 HSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQ-NGERVNHVNLPPWARNDPRL 3375

  Fly  2265 FIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAV 2329
            ||.|||:||||::|||::.|||||:|||||||..:.:|:|||:..:|.| :|:..:.:||:|.|:
  Rat  3376 FILIHRQALESDHVSQNICHWIDLVFGYKQKGKASVQAINVFHPATYFG-MDVSAVEDPVQRRAL 3439

  Fly  2330 EGMINNFGQVPSQLLREPHPRRLTQDETALKL-VRAELRRPD----LTQFL-------DKVVQYY 2382
            |.||..:||.|.||....|..|     ...|| :..||  |.    |.||.       .|.:.|.
  Rat  3440 ETMIKTYGQTPRQLFHTAHASR-----PGAKLNIEGEL--PAAVGLLVQFAFRETREPIKEITYP 3497

  Fly  2383 CELSTPKD--------------PIVYLSPPRSPPRSFLQLSPD-VLVSISKSTILGCNSWLSFDK 2432
            ..||..|.              |:|..|.|.......||..|. .:..:|::..|    .:::.|
  Rat  3498 SPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSQNFCL----LMTYSK 3558

  Fly  2433 DQGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKA 2497
            :||                     ..|......|..|:.:.|   ||    ||.||:    |.|.
  Rat  3559 EQG---------------------VRSMNNTDIQWSAILSWG---YA----DNILRL----KSKQ 3591

  Fly  2498 -------VASVTRHLDIITCIAL-DNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTG 2554
                   :.|..:| .:.:|..: |:|  .|.|||:   |.|.:..||:...|:.:.|.:.:   
  Rat  3592 SEPPINFIQSSQQH-QVTSCAWVPDSC--QLFTGSK---CGVITAYTNRFTSGTPSEIEMES--- 3647

  Fly  2555 QSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRT 2619
            |.|                    ||||.:.|:|:.:.....:::|.|.|||..|:.|....:|::
  Rat  3648 QMH--------------------LYGHTEEITSLCVCKPYSVMISVSRDGTCIVWDLNRLCYVQS 3692

  Fly  2620 L-------KPIGCTESCVQISFVTLSYHGHIAFSALDDTSHSVHVYSINGCSLGSKYVSGRVTGL 2677
            |       ..:..:|:...|:.|..|..|          ...:.::::||..:|..:....:..:
  Rat  3693 LAGHKSPVTAVSASETSGDIATVCDSAGG----------GSDLRLWTVNGDLVGHVHCREIICSV 3747

  Fly  2678 ASAS-----DYLVVAD--DAGDITMSRLHGLKPVFDIPL---HVPIQTVVVTPGNTHILAPLRDG 2732
            |.::     ...|:|.  :.|.:.:.....||||.:|..   :.||.::..:....|:.....||
  Rat  3748 AFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSDG 3812

  Fly  2733 RLAVIA 2738
              .|||
  Rat  3813 --TVIA 3816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 24/142 (17%)
DUF4704 906..1162 CDD:292415 63/395 (16%)
DUF4800 1650..1899 CDD:292675 53/279 (19%)
PH_BEACH 1952..2046 CDD:275391 25/94 (27%)
Beach 2072..2351 CDD:280327 142/290 (49%)
WD40 <2428..2734 CDD:225201 69/330 (21%)
WD40 repeat 2465..2503 CDD:293791 12/44 (27%)
WD40 2468..2687 CDD:295369 52/238 (22%)
WD40 repeat 2509..2580 CDD:293791 16/71 (23%)
WD40 repeat 2585..2621 CDD:293791 11/42 (26%)
LystXP_038952047.1 PH_BEACH 3059..3154 CDD:405526 27/106 (25%)
Beach 3171..3461 CDD:214982 143/291 (49%)
WD40 3568..3817 CDD:421866 68/301 (23%)
WD40 repeat 3568..3604 CDD:293791 12/46 (26%)
WD40 repeat 3608..3653 CDD:293791 16/72 (22%)
WD40 repeat 3658..3694 CDD:293791 10/35 (29%)
WD40 repeat 3701..3734 CDD:293791 7/42 (17%)
WD40 repeat 3744..3785 CDD:293791 8/40 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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