Protein Alignment CG43367 and BPH1

DIOPT Version :10

• Sequence 1: NP_001189048.2
• Gene: CG43367 / 38505
• FlyBaseID: FBgn0263110
• Length: 2754
• Species: Drosophila melanogaster
• Sequence 2: NP_009961.2
• Gene: BPH1 / 850398
• SGDID: S000000628
• Length: 2167
• Species: Saccharomyces cerevisiae
• Alignment Length: 2521
• Identity: 518/2521 - (20%)
• Similarity: 923/2521 - (36%)
• Gaps: 797/2521 - (31%)

  Fly   459 VELLDTCFMLGYDESEHFLLLPEVMLRLLNW----VPTLQEREQLHVTSL-VLKGCTDNYRTKTV 518
            ::||:|     ..:|..|.::.:::|.|.|.    ..||.:.::|.:... :|....|::::..:
Yeast   109 IQLLET-----LTDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRIRIFEILSNKNDSWKSTLL 168

  Fly   519 ACGSHIIKAVCGCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLRQGTKF------- 576
            .                        :|||:....:..:...|.||:.::  |.:..||
Yeast   169 Q------------------------KNLIEWYIFMLSVDCTPLELQNLY--LHKELKFCNGILNS 207

  Fly   577 ----------PQFKQLQQTLVVIALQ-SLRGSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFI 630
                      ..:.|.:.|..:..:| |.|.:||                             |:
Yeast   208 LTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNS-----------------------------FL 243

  Fly   631 FHILVRFNQLKEQSNSRRML-----LTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKT 690
            |:|  .||.:    .|.|::     :.|:...|.    |...|.|.::......|:..
Yeast   244 FYI--EFNSV----TSNRIMTIERHIYLEIKEGQ----FCISNDNYIIGLFENFEFEA------- 291

  Fly   691 LMDGQWHYLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGEV 755
               |..:::.|.|....|      |.:|||.......||...::.: .:.|.:|:::.
Yeast   292 ---GTLYFIGVLIDHNNR------ITLYVDGSMINQLTLFENSICQ-LSTCELGSMIC------- 339

  Fly   756 AKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNY-FTLPMRTQTAFDPNVKNFPIGMQDTV 819
                     |.:......:.|:|.......|.|..:|| :|...:.:   .|.|.:.   .||.:
Yeast   340 ---------SIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFSKKKE---GPEVLSL---CQDFL 389

  Fly   820 FGEQTCLNGHLGGVLLADPTTSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQ 884
            ..:     .|    |:|.|||.:.         |:.:..:.:|||:.: .:....|..|    .|
Yeast   390 IAK-----AH----LMARPTTEIS---------STKYIDEIELLEMEN-IIIDVNPNDI----LQ 431

  Fly   885 DLIPGGKYPGRINAQHCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAP 949
            |......:          .||.:|:.||..     :|.:.:.. ..:::::....||.:|:..|
Yeast   432 DFTESSNF----------TVKFEESTNSKN-----IPEVGKCY-FYRSSNLVSKFVSIDSIRLA- 479

  Fly   950 TPSAEEFTDWEMLSSNSYTEWKMLQHPLASFLCLLRYL-----------------THEHETNQEQ 997
                  |.:  |..|.|..:   |.|.::..:.|||.:                 |.:.:..|:
Yeast   480 ------FLN--MTESGSIDD---LFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQKITQD- 532

  Fly   998 LLSSEC-LAIVGTMLQRCPPSLFDVNALMATHLLMESLQGHKAEAGGQLLDA-LYAHIVFDFAIW 1060
             ||... :......|:.|.....|::..:                   :||. .|.:||.:..:|
Yeast   533 -LSQPLNIQFFNLFLEFCGWDFNDISKSI-------------------ILDTDAYENIVLNLDLW 577

  Fly  1061 SRLQFQITLGHAQYLSAMIKNDRKFFRKRYGVQFVLDVVRQYYSTPDSISDDDAKTIRATLFGII 1125
            ...:.|.:|....                      |:::|..:....|:       :.|:::.
Yeast   578 YMNEDQSSLASGG----------------------LEIIRFLFFQISSL-------MEASIYS-- 611

  Fly  1126 KFYLQK--DVNIKE--------------------------VNSMITFLASVRQDVVLVEFLEMMT 1162
            ||...|  |:||.|                          ::..:|.|.|......|..||.:..
Yeast   612 KFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSY 676

  Fly  1163 FYVRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQEAAIRFISGLLATSRVHQKYKQVLRL 1227
            ::::.|:.:...::|    |:.:.|::|::|:.     .:...:.:|.::       ..|.:|.:
Yeast   677 YFIKRKDVRSTEIIL----QAVDQLFSFYLDQG-----SDENAKILSEII-------PLKLILMI 725

  Fly  1228 YDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLGLQPDYAGLIFLVYHVSSCDLPVKLEIAKR 1292
            .||..|.:.       ..|::..: |||.:|   |..:|                      :.|:
Yeast   726 MDQIVENNE-------SNPITCLN-ILFKVV---LTNKP----------------------LFKQ 757

  Fly  1293 LLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITSSPPDEEKRRSFGINLDVLLEDNSNFLAQA 1357
            ..:...:|...|:.......::|.|..||:...|                        .|:....
Yeast   758 FYKNDGLKLILTMLCKVGKSYREEIISLLLTYSI------------------------GNYTTAN 798

  Fly  1358 DLITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESEIKELAESVSGAV------ 1416
            ::.:.:|..||          .:|:..:...||   :..|...||..:.....|.|.:|
Yeast   799 EIFSGAEDMIG----------GISNDKITAKEI---IYLAVNFIEWHVINSNASDSSSVLDLNNH 850

  Fly  1417 ----VENANSLFSV-IRQTTHDLQDTFESLTQGSSTDTADGSQTPSIQREESLSSDTSSQSPHGP 1476
                ||:..||.:| |.::..|.:   :|....|..|.     :.::...|.:|...||......
Yeast   851 ILRFVEDLKSLSAVPINESVFDPK---KSYVMVSLLDL-----SIALNESEDISKFKSSSKVISE 907

  Fly  1477 PKKSD---SLESTSAFDFVADGDV--------DTEEQLVY--LVSNTLFNIFWRGIPNDHPQCWQ 1528
            ..|.:   :|...:|:||    :|        .||.:|||  .|.|....:....|....|:...
Yeast   908 LIKGNIMCALTKYAAYDF----EVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILN 968

  Fly  1529 ERGQVLGCINLLALNNELITSHLSLRLR----------------------ILEMAVQ--ASLFDL 1569
            :.......:||:.|.:....|:|...||                      :|...:|  .|.|..
Yeast   969 DLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYH 1033

  Fly  1570 SEHGSQTLVNQENASHILRMVYE--LVVLGSNEDESKKCSTKLLDGVLALLDALMIFQQGSSDDW 1632
            .::.|::.:.|:....|:.::|.  |..:...::|.:..|..|      :....::|..|:.|:.
Yeast  1034 FKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESL------MAHQEVLFAHGACDNE 1092

  Fly  1633 SDMIRLCLGLLL--------KCSHHPNPGIVAMATAKLHAILQSRSTE--------DPAELSYLL 1681
            :      :||||        .|.:  |..:...    :..|::::..:        |||..|.:|
Yeast  1093 T------VGLLLIFFANRLRDCGY--NKAVFNC----MKVIIKNKERKLKEVACFFDPANKSEVL 1145

  Fly  1682 YSINRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTS 1746
                ..|.|.:...|.|..:.:                          |...|.|||:.|..
Yeast  1146 ----EGLSNILSCNNSETMNLI--------------------------TEQYPFFFNNTQQV--- 1177

  Fly  1747 KKWRNFIERMVKPLYDRYQRDIELHLWEPIN--RFWAECYEACKAASKQRATNQAENRRLFQQKI 1809
                .||..:...|:..       :.:.||:  :...:.||...|.|:....|..:...||::
Yeast  1178 ----RFINIVTNILFKN-------NNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRK-- 1229

  Fly  1810 YMPWKVRQVEEMQRLQAAALQHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENV 1874
                                .:.::|..|:   |:..|:.|.              .|..:.||.
Yeast  1230 --------------------DNTSLDFKIK---KSISRYTYN--------------LKTDREENA 1257

  Fly  1875 ARMRLKLEPQLYPNKHENAANLRDNATSAYDTKEISEFDSTIKNAV------VRDFLADDESSQ- 1932
            ...|..|...::..||........|::..:.:....:||...:..:      ....:.:::::|
Yeast  1258 VFYRNNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLINEEDANQD 1322

  Fly  1933 ---------------LEEELRQLIDTQAQQDVA-------LEKLVMSQD-------CELITLMTK 1968
                           |..|..:.::|...:.|.       :.:|:...|       |.|| :..:
Yeast  1323 TITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCSLI-IGLE 1386

  Fly  1969 VKGRIEVNQSVFTF--------------VDLSPPTEDGSKYDF---------RFSTNKIREVHL- 2009
            :|..|.::.|.:.:              :.||..:::......         |.||....||.:
Yeast  1387 IKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVW 1451

  Fly  2010 ----------RKYNLRRSALEIFLVDQTSYFLNFTTK-TRNKVFTKIVGLP--LP---------- 2051
                      |.:.||..|:|:...::.|.|.:|..| .|:.|...:..:|  ||
Yeast  1452 KLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQ 1516

  Fly  2052 -------NILYGSGRSPA--------------ELLRASGLTQRWINREISNFEYLMYLNTIAGRS 2095
                   :|:..:|...|              .|:....::::|:..|||||.||:.:|.:||||
Yeast  1517 EINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRS 1581

  Fly  2096 YNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYD---SFEDPSGAI 2157
            :|||:|||||||::|||.|:||||.:||::||||||:|..:.|.:.:...:|:   |.|:...|
Yeast  1582 FNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSA- 1645

  Fly  2158 PKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTW-KLLMDNPNDVKEL 2221
             .||||||||::..|..||:|::||....:.||.|.|..|||.|.|:.:.| ....:|..||:||
Yeast  1646 -PFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVREL 1709

  Fly  2222 IPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWAT-TPEEFIAIHRRALESEYVSQHLHHW 2285
            .||||:.||||.|:|.:|.|..|..| |||||:||.||. .|:.||..:|.||||.|||.|||.|
Yeast  1710 TPEFFFLPEFLINVNSYDFGTDQSGK-KVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEW 1773

  Fly  2286 IDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPR 2350
            |||||||||||..|.:::|||...||.|||:||.|.:..||.|:.|:|:||||.|.|:.:||||.
Yeast  1774 IDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPE 1838

  Fly  2351 RLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVY--------------------- 2394
            ::..:  ..:|.....|:..:....:|.:....|.:...|.:::
Yeast  1839 KIACN--VQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFR 1901

  Fly  2395 ----LSPPRSPPRSFLQLSPDVLVSISKSTILGCNSW-----LSFDKDQGFLLEI-------DAT 2443
                |...|...:::|::..|:......:.|.....|     ::.||:.  |:::       .:.
Yeast  1902 TEESLVSLRIVHKNWLKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNG--LIKVWKYRKDKHSV 1964

  Fly  2444 TANLKNRKRIFGP---------FHSSQQPHSQLFAVSTDGKLLYAGGIWD--NSLRVYNLNKGKA 2497
            :.||:|:|.:||.         :|.    ::.|..:...| |:|   :||  |...|..:.....
Yeast  1965 SGNLENKKTMFGHLCELKEMRCYHD----YNTLLTLDISG-LVY---VWDMINFELVRQITNDAQ 2021

  Fly  2498 VASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAIT 2562
            ..::::|           .||.:|.                   ...|.|.:..|.|
Yeast  2022 KVAISQH-----------AGSIMVL-------------------TKNNAISIFNLNG-------- 2048

  Fly  2563 QLNTQNSYSPKPLTVLYGHDDAISSVAIY---------------TELDLVVSGSLDGTVNVYTL- 2611
            |:.|...:.|..:         :||:..:               .|:::::.|..|||:.:|.|
Yeast  2049 QIYTSKKFEPAKI---------VSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELF 2104

  Fly  2612 ---QEGQFVRTLKPIGCTESCVQISFVTLSYHGHIAFSALDDTS--HSVHV 2657
               .....::.||.: |||....|:.:......:::.....||:  |.:.|
Yeast  2105 LNFHNEWAIKLLKQL-CTEKGKAITSIKGQGKTYLSQKRRKDTAEPHEIEV 2154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	Laminin_G_3	644..752	CDD:463865	20/112 (18%)
		DUF4704	906..>1162	CDD:464870	49/302 (16%)
		DUF4800	1646..1899	CDD:464996	42/262 (16%)
		PH_BEACH	1952..2046	CDD:275391	26/135 (19%)
		Beach	2072..2351	CDD:460459	150/283 (53%)
		NBCH_WD40	2395..2742	CDD:466575	54/307 (18%)
		WD40 repeat	2465..2503	CDD:293791	8/39 (21%)
		WD40 repeat	2509..2580	CDD:293791	10/70 (14%)
		WD40 repeat	2585..2621	CDD:293791	9/54 (17%)
BPH1	NP_009961.2	PH_BEACH	1371..1500	CDD:275391	25/129 (19%)
		Beach	1558..1839	CDD:214982	150/283 (53%)
		WD40 repeat	1933..1976	CDD:293791	8/44 (18%)
		WD40 repeat	1981..2017	CDD:293791	9/43 (21%)
		WD40 repeat	2021..2055	CDD:293791	10/71 (14%)