DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43367 and NSMAF

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	NP_001138244.1	Gene:	NSMAF / 8439	HGNCID:	8017	Length:	948	Species:	Homo sapiens

Alignment Length:	888	Identity:	260/888 - (29%)
Similarity:	396/888 - (44%)	Gaps:	173/888 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1868 LSQHENVARMRLKLEPQLY------PNKHENAAN--LRDNATSAYDTKEISEFDSTIKNAVVRDF 1924
            :.:|..||..:::.....|      |.|.|:...  |:.:..|..|  ::.:..:.| .|:::..
Human   146 IKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVETLLQLHRASCLD--KLGDQTAMI-TAILQSR 207

  Fly  1925 LADDESSQLEEELRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPT 1989
            ||           |...|....|::: |||.|....|::|.:....|.:.:..:...|    .|.
Human   208 LA-----------RTSFDKNRFQNIS-EKLHMECKAEMVTPLVTNPGHVCITDTNLYF----QPL 256

  Fly  1990 EDGSKYDFRFSTNKIREVHLRKYNLRRSALEIFLVDQ---TSYFLNF-TTKTRNKVFTKIVGLPL 2050
            ....|...:.:...:|.::.|::.|....||:|..:.   :..:|.| ..:.|:.::..|.....
Human   257 NGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLE 321

  Fly  2051 PNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSD 2115
            .::        ||....|.:.| |....:||::||::||.:|.||.||||||||||||:.||:|.
Human   322 HHV--------AEHTAESYMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSS 377

  Fly  2116 VLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVE 2180
            .|||::|.:|||||||:|.:|.:....:..:|....:     |||.||:|||:...||.||:|:.
Human   378 ELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPE-----PKFMYGSHYSSPGYVLFYLVRIA 437

  Fly  2181 PFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFP-EFLKNMNKFDLGHLQ 2244
            |  ...:.||:||||.|||.|:||.:|||..:|...|.|||||||:... .||.|..|.|||..|
Human   438 P--EYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQ 500

  Fly  2245 ITKEKVDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYC 2309
             ..:.||||.||.||::||:|:...:.||||.|||:|||.||||||||||||..|..|.|||:..
Human   501 -GGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPL 564

  Fly  2310 SYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQF 2374
            :|||.|||:.|.:|.|:.|:...|..|||.|.||...|||||:|               |.. :.
Human   565 TYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRIT---------------PKF-KS 613

  Fly  2375 LDKVVQYYCELSTPKDPIVYLSPPRSP-PRSFLQLSPDVLVSISKSTILGCNSWLSFDKDQGFLL 2438
            |.:...|...::.            || ..||..|:       .:|..|..|:.......:.:.:
Human   614 LSQTSSYNASMAD------------SPGEESFEDLT-------EESKTLAWNNITKLQLHEHYKI 659

  Fly  2439 EIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAG----------------------G 2481
            ..:|.|....:|.. ...|.:||....::|  |.:.|:|...                      .
Human   660 HKEAVTGITVSRNG-SSVFTTSQDSTLKMF--SKESKMLQRSISFSNMALSSCLLLPGDATVITS 721

  Fly  2482 IWDNSLRVYNLNKGKAVASVTRHLDIITCIAL-DNCGSYLVTGSRDCTCIVWSIQTNQQGGGSTN 2545
            .|||::..|::..|:...::..|.|.::.|.. ||   .|.:.|.|.|..|||....:..|
Human   722 SWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDN---RLYSASWDSTVKVWSGVPAEMPG---- 779

  Fly  2546 NIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYT 2610
                   |.:.|...:.:|.               ||.::.::::.....|:|||:.:||||::.
Human   780 -------TKRHHFDLLAELE---------------HDVSVDTISLNAASTLLVSGTKEGTVNIWD 822

  Fly  2611 LQEGQFVRTL---KPIGC---------------TESCVQISFVTLSYHGHIAFSALDDTSHSVHV 2657
            |.....:..:   ..|.|               |:.|:.:..|..   |.:..|...|......|
Human   823 LTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQT---GMLISSMTSDEPQRCFV 884

  Fly  2658 YSINGCSLGSKYVSGRVTGLASASDYLVVADDAGDITMSRLHG 2700
            :.      |:..:||      |.|..|:|.|..|.....|:.|
Human   885 WD------GNSVLSG------SQSGELLVWDLLGAKISERIQG 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605
		DUF4704	906..1162	CDD:292415
		DUF4800	1650..1899	CDD:292675	8/38 (21%)
		PH_BEACH	1952..2046	CDD:275391	19/97 (20%)
		Beach	2072..2351	CDD:280327	144/279 (52%)
		WD40	<2428..2734	CDD:225201	62/314 (20%)
		WD40 repeat	2465..2503	CDD:293791	9/59 (15%)
		WD40	2468..2687	CDD:295369	51/259 (20%)
		WD40 repeat	2509..2580	CDD:293791	14/71 (20%)
		WD40 repeat	2585..2621	CDD:293791	9/38 (24%)
NSMAF	NP_001138244.1	PH-like	223..316	CDD:302622	19/96 (20%)
		Beach	335..606	CDD:280327	144/279 (52%)
		WD40	<645..947	CDD:225201	63/318 (20%)
		WD40	653..945	CDD:238121	62/310 (20%)
		WD40 repeat	664..701	CDD:293791	9/39 (23%)
		WD40 repeat	707..743	CDD:293791	5/35 (14%)
		WD40 repeat	748..782	CDD:293791	12/47 (26%)
		WD40 repeat	798..833	CDD:293791	9/34 (26%)
		WD40 repeat	839..875	CDD:293791	6/38 (16%)
		WD40 repeat	882..914	CDD:293791	11/43 (26%)
		WD40 repeat	920..944	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820