DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43367 and AT1G58230

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	NP_001322631.1	Gene:	AT1G58230 / 842191	AraportID:	AT1G58230	Length:	2604	Species:	Arabidopsis thaliana

Alignment Length:	2809	Identity:	682/2809 - (24%)
Similarity:	1086/2809 - (38%)	Gaps:	731/2809 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   292 WESA--NNLRRVALQCYALMVIVLQKSSP--EERQIDLVTLVQLYCDALQELLATKHFDSGDANF 352
            ||.|  ||:.:        ::|.|.|..|  ||.:...:.:...|.:...::...:: ||.|.:.
plant   156 WEKAVRNNVMK--------LIIDLMKIRPLCEEDKSAKLQVCSKYLETFTQVKEREN-DSVDLSV 211

  Fly   353 DITSDADQDVAIDMAALSSTVAAVKFFV----TGDAGVSEAVSDS---NLLELLTNLPKLIKPWH 410
            |:.:.....:..|.....:.....:.|:    ..:..:.||..:.   |:|:.||:|
plant   212 DLLAGMRDLIKSDSRYYQALFREGECFLHIVSLLNGNLDEANGEKLVLNVLQTLTSL-------- 268

  Fly   411 ISHSSSLCSTMEALAILARHSPQSASQLRQGERIERLFTSLQEY--GSPTVELLDTCF-ML---G 469
            ::::.:.....:|||               |:..:.|.:.|.::  ..||..|||... ||   .
plant   269 LANNDTSKFAFKALA---------------GKGYQTLQSLLLDFFQWKPTQRLLDALLDMLVDGK 318

  Fly   470 YDESEHFLLLPE-VMLRLLNWVPTLQEREQ---LHVTSLVLKGCTDNYRTKTVACGS-HIIKAVC 529
            :|:....|:..| |::..||.:....|..|   |::...:|:....| |...|..|. |:
plant   319 FDDKGSALIKNEDVIILYLNVLQKSSESLQCYGLNLFQQLLRDSISN-RASCVRAGMLHL----- 377

  Fly   530 GCLLTAESLA--ENCVQNLIKLIEELSKLSIVPAELKCIFSLLRQGTKFPQFKQLQQTLVVIALQ 592
              ||...||.  ::.:..:.:|.:.:...||...:::.||:|||......|  |..::|::..|.
plant   378 --LLDWFSLENDDSVILKITQLTQTIGGHSISGKDIRKIFALLRSERVGNQ--QRYRSLLLACLL 438

  Fly   593 SLRGSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRFNQLKEQSNSRRMLLTLQTAS 657
            |:........||.:.....||::.....|  ..:.||.|...:|....  ..:.:..:.:..:.:
plant   439 SMLNEKGPTGFFDMNGVESGIVIRTPVQW--PANKGFSFCCWLRVESF--PGDGKMGIFSFMSKN 499

  Fly   658 GSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPKRPFSYSQINIYVDFV 722
            |.|....:..:|...|:...:|:.:...|   .|:..:||::.|:.:..:..:..|.:..||:..
plant   500 GKGCFAALGKDGLSYVSLNLKRQCVNVHT---NLVCKKWHFICVSHSIGRAFWGGSLLRCYVNGD 561

  Fly   723 QKLSATLKVQAVNEPFTVCSIGAVVAPPQ--------------P--GEVAKTGNMPRSSSQESGS 771
            ...|.......|.:..|.|.||..:..|.              |  |::........|.|.|...
plant   562 LVSSERCSYPKVTDVLTSCLIGTRITLPHIQDNDGLESIRDVFPFFGQIGPVYLFNDSLSSEQVQ 626

  Fly   772 SGYKGMLPSLLERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLGGVLLA 836
            :.|     ||....:.|.:.|..|.|      |..|  .||.|:.|...|             ||
plant   627 AIY-----SLGPSYMYAFLENEMTCP------FSDN--PFPSGILDGKDG-------------LA 665

  Fly   837 DPTTSLKTIFDAGANFSS---IFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINA 898
            .     |..|...|..|.   :|:.......|..|..|           ..|::.|        .
plant   666 S-----KVSFGLNAQASDGRRLFNVSRVSDHLQERLAF-----------EADIMVG--------T 706

  Fly   899 QHCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLS 963
            |.|....:|:.|..:||||...|    |||  |:......:::||:   :..|:.|..|
plant   707 QLCSRRLLQQIIYCVGGISVFFP----LIT--QSDRCESETLNEET---SAMPTKERMT------ 756

  Fly   964 SNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALMA-T 1027
                          |..:.|:..:..|:..||:|:.......|:|.:||...|...::..|.: .
plant   757 --------------AEVIELIASVLDENPANQQQMHLLAGFPILGFLLQSIQPKQLNLETLSSLK 807

  Fly  1028 HLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFRKRYGV 1092
            ||.........||   ||::...:.|..:..||....:.:......:|...:.||.:.......:
plant   808 HLFNVISSSGFAE---QLVEDAISSIFLNPHIWLHAAYNVQRELYMFLIQQLDNDPRLLGSLCRL 869

  Fly  1093 QFVLDVVRQYY---------STP---------DSISDDDAKTIRATLFGIIKFYLQKDVNIKEVN 1139
            ..|:|:|..:|         |.|         :..|.|:...||..|..:.:..|:::::..:|.
plant   870 PRVIDIVWNFYWESERYCKGSKPLMHPTRTIAERPSRDEIHKIRLLLLSLGEMSLRQNISSGDVK 934

  Fly  1140 SMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLL--YNFFVD---KSYSNE 1199
            ::..|..:. |||..:|  :::...:|..:....:|..|   :..||:  .:.|||   :.| ..
plant   935 ALTAFFETC-QDVACIE--DVLHMVIRAISQTSVLVSFL---EQVNLIGGCHIFVDLLQRDY-EP 992

  Fly  1200 IQEAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLG- 1263
            |:..:::|:..|               |||..:|:. .|.||:    |::..|.......:.:|
plant   993 IRLLSLQFLGRL---------------LYDVPSERK-GPKFFN----LAVGRTKSLSQGHKKIGA 1037

  Fly  1264 -LQPDYAGLIFLVYHVSSCD------LPVKLEIA--KRLLQT---------------TFVKQQST 1304
             .||.:..:...::.....|      ..|.|..|  |::||.               .|:.|...
plant  1038 RTQPIFLAMSDRLFQYPQTDNLRATLFDVLLGGASPKQVLQKHNQVDKHRSKPSNSHFFLPQIFV 1102

  Fly  1305 VAMAKQTGWQESIARLLIRKPI----TSSPPDEEKRRSFG--------INLDVLLEDNSNFLAQA 1357
            ......:|.::.:||:.|...|    .|:|.:.|....||        :.|||:.:..|..|...
plant  1103 FIFEFLSGCKDGLARMKIISDILDLLDSNPMNVEALMEFGWSAWLTASMKLDVIKDYRSELLNHD 1167

  Fly  1358 DLITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESEIKELAESVSGAVVENANS 1422
            |                          |.||| |..|.....|:   :.....||.|...:...:
plant  1168 D--------------------------LALNE-QHFVRGLFCVV---LCHYILSVKGGWQQLEET 1202

  Fly  1423 LFSVIRQTTHD-------LQDTFESLTQGSSTDTADGSQTPSIQREESLSSDTSSQSPHGPPKKS 1480
            :..::.|:.|:       |:|.:|.|                |||...|||:.
plant  1203 VNFILLQSEHNDVPYRSFLRDLYEDL----------------IQRLVELSSED------------ 1239

  Fly  1481 DSLESTSAFDFVADGDVDTEEQLVYLVSNTLFNIFWRGIPNDHPQCWQERGQVLGCINLLALNNE 1545
                                            |||.     .|| |   |..||   .||.|.:|
plant  1240 --------------------------------NIFL-----SHP-C---RDNVL---YLLRLVDE 1260

  Fly  1546 LITSHLSLRLRILEMAVQAS--LFDLSEHGSQTLVNQENASHILRMVYELVVLGSNEDESKKCST 1608
            ::......||....::...|  |..|......||...|:....|     ...:..|.:..:.|:|
plant  1261 MLVREFGSRLLFPAISTDFSEDLLQLGNREDPTLGLDESFQRFL-----TEEISRNTECQQSCTT 1320

  Fly  1609 KLLDGVLALLDALMIFQQGSSDDWSDMIRLCLGLLLKCSHHPNPGIVAMATAKL----------H 1663
                     :..||     :::.|.::......::...:   ..|.|.|:...|          .
plant  1321 ---------VTELM-----TNERWWNLYDNLWKIICDIN---GRGPVKMSPKSLATGPSIGQRAR 1368

  Fly  1664 AILQSRSTEDPAELSYLLYS--INRALDNAIEVGNPEEYSFLMPVMKALL---EKC-RVAFNLDS 1722
            .:::|.:. ..||::.::.|  |..||...:...          |.||:|   ||| |:.|.|.:
plant  1369 GLVESLNV-PAAEMAAVVVSGGIGSALSGKMNKN----------VDKAMLLRGEKCPRIVFRLVT 1422

  Fly  1723 TLPDLPS-----------TSSGPVFF--NDFQMYSTSKKWRNFIERM--VKPLYDRYQRDIELHL 1772
            ....:.|           ||..|.|.  :|.|   :..:...||..:  |:..|.:.......|:
plant  1423 LYLCMSSLEKATRCVQQVTSLLPSFLAADDEQ---SKSRLHLFIGCLLYVRSQYGKLDDGARFHV 1484

  Fly  1773 WEPINRFWAECYEACKAASKQRATNQAENRRLFQQ------------------------KIYMPW 1813
            ...:.|....|.::..|.|.....:.:::..:|::                        |..:..
plant  1485 ISHLIRETVSCGKSILATSGMNKDDSSDSGGIFKEMGSIQNLIHKDRVLAAVTDETTYMKTLISD 1549

  Fly  1814 KVRQVE----------------------EMQ------------RLQAAALQHKTIDSHIRKRWKT 1844
            :.|||:                      |:|            |..:..|.|:....::.::|..
plant  1550 RTRQVQALGERNNETLSIECNSKKAFDGELQNVLKTVVTWDENRRVSVQLSHEEQQQNVTEKWIH 1614

  Fly  1845 AKRFLYGPRGPWYTGEVDEEF---WKLSQHENVARMRLKLEPQLYPNKHENAANLRDNATSAYDT 1906
            ..|.|...||||.........   |||.:.|:..|.|    |:|..|.|.:.......:||....
plant  1615 MLRSLMDERGPWSATPFPNNILNRWKLDRTEDSWRRR----PKLRRNYHFDERLCHPPSTSTATE 1675

  Fly  1907 KEISEFDSTIKNAVV------RDFL---------------ADDESSQLEEELRQLIDTQAQ---- 1946
            .|.|...:..|:.|:      :.||               .:::|||.|:   ..:||.|.
plant  1676 NETSNVINESKSGVIHIPEQMKKFLLKGIRRITDEGGSDSCENDSSQAEQ---SFMDTSADIQFS 1737

  Fly  1947 ---------QDVALEK------------LVMSQDCELITLMTKVKGRIEVNQSVF---------- 1980
                     :||..:|            ::.|..|.|:|...|:.|.:.|.::|.
plant  1738 ELVRTSSGLKDVVQDKVDASSLEVGTSEVLTSVPCVLVTPKRKLAGWLAVMKNVLHFSGEFLVEG 1802

  Fly  1981 -------------------------------------TFVDLSPPTEDGS---------KYDFRF 1999
                                                 ||:||    |.|:         |...|:
plant  1803 TGGSAVFKNFSTSKGSDVTKAENKQNLVKWSSPYDSETFLDL----ESGNKNKKPLKKVKRHRRW 1863

  Fly  2000 STNKIREVHLRKYNLRRSALEIFLVDQT-SYFLNFTTK------------TRNK-VFTKIVGLPL 2050
            ...|::.||..:|.|:.:|||||..:.. ..||||.::            |||: :|.|.|
plant  1864 KIGKVKSVHWTRYLLQYTALEIFFQESVPPVFLNFASQKNAKEVGMLIVSTRNEFLFPKNV---- 1924

  Fly  2051 PN-----ILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILA 2110
            |.     |.:...|...|:  |.....||..|||:||||||.|||:||||||||:|||||||::|
plant  1925 PRDRTAMISFVDRRIAMEM--AETARDRWRRREITNFEYLMILNTLAGRSYNDLTQYPVFPWVVA 1987

  Fly  2111 DYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHY 2175
            ||:|:.||.:...:|||||||:|.::.:.......:|.||.||.  ||.|:||:|||:...||:|
plant  1988 DYSSETLDFSKASTFRDLSKPVGALDTRRFEIFEDRYHSFSDPD--IPSFYYGSHYSSMGSVLYY 2050

  Fly  2176 LLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDL 2240
            |||:|||||||..||.|:||.|||.|.|:..:::..:.|.:|||||||||||.||||.|.|.:.|
plant  2051 LLRLEPFTSLHRSLQGGKFDHADRLFQSVEGSFRNCLSNTSDVKELIPEFFYMPEFLVNSNSYHL 2115

  Fly  2241 GHLQITKEKVDDVILPAWAT-TPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALN 2304
            |..| ..|.:.:|.||.||. :||.|||.:|.||||||||.|||.|||||||:||:|..|.||.|
plant  2116 GVKQ-DGEPLGEVCLPPWAKGSPEMFIARNREALESEYVSSHLHDWIDLIFGHKQRGKPAVEAAN 2179

  Fly  2305 VFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRP 2369
            :|||.:||||||::.:.:.::..|:|..|.||||.|.|:.|:.||||
plant  2180 IFYYLTYEGAVDVENMEDQLQISAIEDQIANFGQTPIQIFRKKHPRR------------------ 2226

  Fly  2370 DLTQFLDKVVQYYCELSTPKDPI---VYLSPPRSPPRSFLQL---SPDV----------LVSISK 2418
                             .|..||   :|.:|......|.|..   ||..          :|.:::
plant  2227 -----------------GPPIPIAHPLYFAPASINLSSILPATTHSPSAVLYVGVVDSNIVLVNQ 2274

  Fly  2419 STILGCNSWL----------SFDKDQGFLLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVSTD 2473
            ...|....||          :|...|.....:.:...:.:|   |..|...:.:..||.||....
plant  2275 GLTLSVKIWLTTQLHSGGNFTFSSAQDPFFGVGSDVLSPRN---IGSPLADNVELGSQCFAAMQM 2336

  Fly  2474 --GKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSYLVTGSRDCTCIVWSIQT 2536
              ...|.:.|.|:||..|.:|..|:.|.|:..|.|:::|:|:....:.|.|||.|.|.:||.|..
plant  2337 PLENFLVSCGNWENSFHVISLTDGRVVQSIRHHKDVVSCVAVTADSTILATGSYDTTVMVWDILR 2401

  Fly  2537 NQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGS 2601
            .:.......|         :|.:.   |......:..|..:|.||||.|:.:.:.|:||:|:|||
plant  2402 MRTPEKRVRN---------THAEV---LRKDIVIADAPSHILCGHDDIITCLYVSTDLDIVISGS 2454

  Fly  2602 LDGTVNVYTLQEGQFVRTLK-PIGCTESCVQISFVTLSYHGHIAFSALDDTSHSVHVYSINGCSL 2665
            .|||...:||:||:::|:|| |.|..     :|.:..|:||.|.....||.  |:|:|||||..|
plant  2455 KDGTCVFHTLREGRYIRSLKHPSGSA-----VSKLAASHHGRIVLYGDDDL--SLHLYSINGKHL 2512

  Fly  2666 GSKYVSGRVT--GLASASDYLVVADDAGDITMSRLHGLKPVFDIPLHVPIQTVVVTPGNTHILAP 2728
            .|...:||:.  .|:...::||.|.|.|.|.:..::.|:.|........|.|.:........||.
plant  2513 ASSESNGRINCLELSKCGEFLVSAGDQGQIIVRSMNTLEVVKRYNGAGKIITSLTVTQEECFLAG 2577

  Fly  2729 LRDGRLAVIAVQLP 2742
            .:||.|.|.:::.|
plant  2578 TKDGALLVYSIENP 2591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605	20/122 (16%)
		DUF4704	906..1162	CDD:292415	58/274 (21%)
		DUF4800	1650..1899	CDD:292675	64/340 (19%)
		PH_BEACH	1952..2046	CDD:275391	36/175 (21%)
		Beach	2072..2351	CDD:280327	158/279 (57%)
		WD40	<2428..2734	CDD:225201	95/320 (30%)
		WD40 repeat	2465..2503	CDD:293791	14/39 (36%)
		WD40	2468..2687	CDD:295369	75/223 (34%)
		WD40 repeat	2509..2580	CDD:293791	16/70 (23%)
		WD40 repeat	2585..2621	CDD:293791	16/35 (46%)
AT1G58230	NP_001322631.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	348	1.000	Domainoid score	I226
eggNOG	1	0.900	-	-		E1_KOG1787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	1	1.000	-	-		FOG0003051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820