DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43367 and Lrba

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	XP_006502410.1	Gene:	Lrba / 80877	MGIID:	1933162	Length:	2871	Species:	Mus musculus

Alignment Length:	3137	Identity:	674/3137 - (21%)
Similarity:	1094/3137 - (34%)	Gaps:	1133/3137 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 TGD----AGVSEAVSDSNLLELLTNLPKLIKPWHISHSSSLCSTMEALAILARHSPQSASQLRQG 441
            |||    .|..|..::...|.|...||                                   .:|
Mouse    14 TGDDGGGGGKEETPTEGGALSLKPGLP-----------------------------------IRG 43

  Fly   442 ERIE-RLFTSLQEYGS-PTVELLDTCFML---GYDESEHFLLLPE-----VMLRLLNWVPTLQER 496
            .|:: .:.|.|.|.|. ...::::|.|.|   |..:.|...::.|     .|:.||.......:.
Mouse    44 IRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGESIMCMVELLEKCDVTCQA 108

  Fly   497 EQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLTAESLAENCVQNLIKLIEELSKLSIVPA 561
            |...:.:.:||   .:.|...|.....:::.|.|.:...:|:..:.   |:.::..|:..::...
Mouse   109 EVWSMFTAILK---KSIRNLQVCTEVGLVEKVLGKIEKVDSMIADL---LVDMLGVLASYNLTVR 167

  Fly   562 ELKCIFSLLRQGTK--FPQ--------FKQLQQTLVVIALQSLRGSNSCAEFFSIEQPTDGILVP 616
            |||..||.| ||.|  :|.        .|.:.|.....|..:..|.::.|           |.:|
Mouse   168 ELKLFFSKL-QGDKGQWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAA-----------IALP 220

  Fly   617 DIRNWTISGSYGFIFHILVRFNQLK--EQSNSRRMLLTLQTASGSGFEV-FVQPNGNVVVAALTR 678
            .|..|....  ||.||..:|.:.:.  .....:..|...:|:.|.|:.. ||  .|.:::
Mouse   221 PIARWPYQN--GFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV--GGCLII----- 276

  Fly   679 REYLTSSTATKTLMDGQWHYLTVAITPPK----------RPFSYSQINIYVDFVQKLSATLKVQA 733
                   |:.|:...|..|.:.....|.|          ..:..|::..||:
Mouse   277 -------TSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVN------------- 321

  Fly   734 VNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANVSNYFTLPM 798
                               ||:|..|.:                                 |..:
Mouse   322 -------------------GELASYGEI---------------------------------TWFV 334

  Fly   799 RTQTAFDPNVKNFPIGMQDT-----VF-GEQTCLNGHLGGVLLADPTTSLK--TIFDAGANFSSI 855
            .|...||   |.| :|..:|     || |:.|.:      .|.:|...:.:  .|:..|..:...
Mouse   335 NTSDTFD---KCF-LGSSETADANRVFCGQMTAV------YLFSDALNAAQIFAIYQLGLGYKGT 389

  Fly   856 --FSQDNDLL------------ELNSRFVFCYAPGAIWHGTCQDLIPGGK------YPGRINAQH 900
              |..::||.            :|:|...|.|.|.|.....|.:..|...      .|..:..|.
Mouse   390 FKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHALMLQD 454

  Fly   901 CKIV---KIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEML 962
            .|.|   .||..::||||:..:.|:..:|......:|       |..|:...|
Mouse   455 VKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYKQYLSD-------EVDLTICTT------------ 500

  Fly   963 SSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFD---VNAL 1024
                             .|..:..|.......|||:|:.:...::|..|::...|...   :...
Mouse   501 -----------------LLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHVSRAVLELC 548

  Fly  1025 MATHLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFR-- 1087
            :|....:.:||.     |..||..|..||:.:.|:|.....::.|....|||.........:.
Mouse   549 LAFSKYLSNLQN-----GMPLLKQLCDHILLNPAVWIHTPAKVQLMLYTYLSTEFIGTVNIYNTI 608

  Fly  1088 KRYG-VQFVLDVVRQYY----------STPDSI-----SDDDAKTIRATLFGIIKFYLQKDVNIK 1136
            :|.| |..::..::.||          .||..:     :..:..::||.|...||..:.||..:|
Mouse   609 RRVGTVLLIMHTLKYYYWAVNPQDRSGITPKGLDGPRPNQKEILSLRAFLLMFIKQLVMKDSGVK 673

  Fly  1137 --EVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQS----------ANLLYN 1189
              |:.:::.:|.::.:|..|::.|:::            :.|:...|.|          ..::|.
Mouse   674 EDELQAILNYLLTMHEDDNLMDVLQLL------------VALMAEHPNSMIPAFDQRNGLRVIYK 726

  Fly  1190 FFVDKSYSNEIQ----------------EAAIRFISGL--------------------------- 1211
            ....||....:|                :|.:....||
Mouse   727 LLASKSEGIRVQALKALGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTMYNVLFEIL 791

  Fly  1212 ---LATSRVHQKY---------------------------------------KQVLRLYDQTTEQ 1234
               :.|..:|:::                                       ..:::|::.:.|.
Mouse   792 IEQICTQVIHKQHPDPDSTVKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSREN 856

  Fly  1235 SM-----------------------------------------------FPGFFSFITPLSLS-S 1251
            ..                                               :.|:..::..||:: |
Mouse   857 RRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYHAVKYEWGGWRVWVDTLSITHS 921

  Fly  1252 TILFHLVDEML--------------------GLQPDYAGLIFLV------YHVSSCDLPVKLEIA 1290
            .:.|.:..|.|                    .|.|:..|....|      .|....|.|:.....
Mouse   922 KVTFEIHKENLANIFREEQRKGDEETGPCSSSLVPEGTGATRGVDVSVGSQHEDRKDSPISPHFT 986

  Fly  1291 KRLLQTTFVKQQSTVAMAKQTGW----------------QESIARLLIRKPITSSPPDEEKRRSF 1339
            :...:.:.:.:.|::..|..|..                ||.:.:..:.:..|:...|:.:..|.
Mouse   987 RNSDENSSIGRASSIDSASNTELQTHDMSSDEKKVERENQELLDQATVEETATNGAKDDLETSSD 1051

  Fly  1340 GINLDVLLEDNSNFLAQA-DLITFSEQEIGLAQ------------LQQQQQEELSDSGLILNEIQ 1391
            ......:   |||.|... |.:|.||....::.            |::...||..|...:..:::
Mouse  1052 AAEPVTI---NSNSLEPGKDTVTISEVSASISSPSEEDAAEMPELLEKSGVEEEEDDDYVELKVE 1113

  Fly  1392 ASVTEAATV------------------------------IESEIKEL--------AESVSGAVVE 1418
            .|.||.|.:                              :|:.|.::        :|......|.
Mouse  1114 GSPTEEAGLPTELQGEGLSVAASEGREEPDMCGHGCEVQVEAPITKIHNDPETTDSEDSRFPTVA 1178

  Fly  1419 NANSLF---------SVIRQTTHDLQDTFESLTQ-----GSSTDTADG-SQTPSIQREE------ 1462
            .|.||.         :.::..:|::.|.....|.     .|.:|.||. |:.|:...::
Mouse  1179 TAGSLATSSEVPVPQATVQSDSHEMLDGGMKATNLAGETESVSDCADNVSEAPATSEQKITKLDV 1243

  Fly  1463 -SLSSDT------SSQSPHGPPKKSDSLESTSAFDFVADGDV-DTEEQLVYLVSNTLFNIFWRGI 1519
             |::|||      :|.|...|..:...||.:...:..|.|.. |..:|......:|:|.|
Mouse  1244 SSVASDTERFELKASTSTEAPQPQRHGLEISRQQEQTAQGTAPDAVDQQRRDSRSTMFRI----- 1303

  Fly  1520 PNDHPQC-WQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVNQENA 1583
                |:. |.:            ::..|:|.        |..:::..:.....|.::|:::..|:
Mouse  1304 ----PEFKWSQ------------MHQRLLTD--------LLFSIETDIQMWRSHSTKTVMDFVNS 1344

  Fly  1584 S----------HILRMVYELVVL--------------GSNEDE--------SKKCSTKLLDGVLA 1616
            |          |::..|.:.:|:              .::|.|        |.:.|...|..:::
Mouse  1345 SDNVIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLIS 1409

  Fly  1617 LLDALMIFQQGSSDDWSD-----------MIRLCLGLL--------LKCSHHPN---PGIVAMAT 1659
            |:|.|:.   .||..:::           ::|.||.|:        |:|..|..   .|..|.::
Mouse  1410 LVDVLIF---ASSLGFTEIEAEKNMSSGGILRQCLRLVCAVAVRNCLECQQHSQLKARGDTAKSS 1471

  Fly  1660 AKLHAILQS---------------------------------------RSTED------------ 1673
            ..:|:::..                                       |..||
Mouse  1472 KTIHSLIPMGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQFLALAVV 1536

  Fly  1674 --------------------------------------------PAELSYLLYS----------- 1683
                                                        |||.|.|..|
Mouse  1537 YFISVLMVSKYRDILEPQDERHSQSLKETSSDNGNASLPDAENTPAEFSSLTLSSVEESLEGTSC 1601

  Fly  1684 ------------------------------------------------INRALDNAIEVGN--PE 1698
                                                            :|::.:..|:.||  ..
Mouse  1602 TRRRDSGLGEETASGLGSGLSVASPAAPLGVSAGPDAISEVLCTLSLEVNKSQETRIDGGNELDR 1666

  Fly  1699 EYSFLMPVMK-----------------------ALL-----------------------EKCRVA 1717
            :.:..:||.|                       |||                       ....:|
Mouse  1667 KVTPSVPVSKNVNVKDILRSLVNMPADGVTVDPALLPPACLGALGDLSVDPPMQFRSFDRSVIIA 1731

  Fly  1718 FNLDSTLPD--------------------------------------LPSTSS-GPV-------- 1735
            ....|.||.                                      |||.:: |.|
Mouse  1732 TKKSSVLPSALTTSAPSSAVSVVSSVDPTHASDTGGESPGSRSPNAKLPSVAAVGSVPQDPAAHM 1796

  Fly  1736 -------------------FFNDFQ-----------------------------------MYSTS 1746
                               .|.||.                                   |...|
Mouse  1797 SITERLEHALEKAAPLLREIFVDFAPFLSRTLLGSHGQELLIEGTSLVCMKSSSSVVELVMLLCS 1861

  Fly  1747 KKWRNFIER--------MVKP--LYDRYQRDIELHLWEPINRFWAECYEACKAASKQRATN---Q 1798
            ::|:|.|::        :|..  |..:..:|   ||....|       ||....|:|||.:   .
Mouse  1862 QEWQNSIQKNAGLAFIELVNEGRLLSQTMKD---HLVRVAN-------EAEFILSRQRAEDIHRH 1916

  Fly  1799 AENRRLFQQKIYMPWKVRQVEEM--QRLQAAALQ-HKTIDSHIRKRWKTAKRFLYGPRGPWYTGE 1860
            ||...|..|  |...| |:.|:|  ..::||..: |.|....|:|    ....|....|.|.:..
Mouse  1917 AEFESLCAQ--YSADK-REEEKMCDHLIRAAKYRDHVTATQLIQK----IINLLTDKHGAWGSSA 1974

  Fly  1861 VD--EEFWKLSQHENVARMRLKL--EP--QLYPN-------KHENAANLRDNATSAYDTKEISEF 1912
            |.  .|||:|...|:..|.|.:.  .|  ..:|.       :|....|......:|.|...:::.
Mouse  1975 VSRPREFWRLDYWEDDLRRRRRFVRNPLGSTHPEATLKTAVEHGQCLNHSLPIAAAADEDILAKG 2039

  Fly  1913 DSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQQDVA-LEKLV----MSQDCELITLMTKVKGR 1972
            ..:||:..:     .:::|:.|..|....||.:..|.. ||.|.    :|...:|:.....|||.
Mouse  2040 KQSIKSQAL-----GNQNSENEALLEGDDDTLSSVDEKDLENLAGPVSLSTPAQLVAPSVVVKGT 2099

  Fly  1973 IEVNQSVFTF-VDLSPPT-----------EDGSKYDFRFSTNKIREVHLRKYNLRRSALEIFLVD 2025
            :.|..|...| ||...|.           .:|....:.|:  :||.:..|:|.|:.:|||||:.:
Mouse  2100 LSVTSSELYFEVDEEDPNFKKIDPKILAYTEGLHGKWLFT--EIRSIFSRRYLLQNTALEIFMAN 2162

  Fly  2026 QTSYFLNFTTKTRNKVFTKIVGLPLPNILYGSG-----------RSPAELLRASGLTQRWINREI 2079
            :.:...||......|   |:|.. ||.:..|:.           .:|.:|.:||.:||||.:|||
Mouse  2163 RVAVMFNFPDPATVK---KVVNY-LPRVGVGTSFGLPQTRRISLATPRQLFKASNMTQRWQHREI 2223

  Fly  2080 SNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVR 2144
            |||||||:||||||||||||:|||||||::.:|.|:.||||.|.:|||||||||.:|||..|...
Mouse  2224 SNFEYLMFLNTIAGRSYNDLNQYPVFPWVITNYESEELDLTLPSNFRDLSKPIGALNPKRAAFFA 2288

  Fly  2145 GKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWK 2209
            .:::|:||..  :||||||||||.::.||.:|||:||||:..::||.|:||.|||.|.|:.:.|:
Mouse  2289 ERFESWEDDQ--VPKFHYGTHYSTASFVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSVSRAWR 2351

  Fly  2210 LLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTPEEFIAIHRRALE 2274
            ....:.:|:|||||||:|.||...|.|.::||.:. ....|.||.||.||.|.|||:.|:|.|||
Mouse  2352 NSQRDTSDIKELIPEFYYLPEMFVNFNNYNLGVMD-DGTVVSDVELPPWAKTSEEFVRINRLALE 2415

  Fly  2275 SEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQV 2339
            ||:||..||.||||||||||:||:|..|||||||.:|||||:|:.||:||.|||||..|.:|||.
Mouse  2416 SEFVSCQLHQWIDLIFGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQT 2480

  Fly  2340 PSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPRSPPRS 2404
            |||||.||||.|.:..:..| |:::.|      .|.|:..|         |.|:.|..|.:.|.:
Mouse  2481 PSQLLIEPHPPRGSAMQAYL-LLQSPL------MFTDQAQQ---------DVIMVLKFPSNSPVT 2529

  Fly  2405 FLQ------LSPDVLVSISKSTILGCNSWLSFDKDQGFL--------LEIDATTA--NLKNRKRI 2453
            .:.      |:...:::::.:.:...|.|.:....||.:        :|||...|  ...:|:::
Mouse  2530 HVAANTQPGLAMPAVITVTANRLFAVNKWHNLPAHQGAVQDQPYQLPVEIDPLIACGTGTHRRQV 2594

  Fly  2454 FGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALD---- 2514
            ......|.|.|||.|.:::|.:.:...|.||.|.|||:.:.||.:..|..|.|::||:|..
Mouse  2595 TDLLDQSIQVHSQCFVITSDNRYILVCGFWDKSFRVYSTDTGKLIQVVFGHWDVVTCLARSESYI 2659

  Fly  2515 --NCGSYLVTGSRDCTCIVWSIQTNQQG-----GGSTNNIPVHALTGQSHLQAITQLNTQNSYSP 2572
              ||  |:::||||.|.::|.......|     ||.|                           .
Mouse  2660 GGNC--YILSGSRDATLLLWYWNGKSSGIGDNPGGET---------------------------A 2695

  Fly  2573 KPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTL 2637
            .|..:|.|||..|:..|:..||.||:|||.:|...:::: .|..:|||:.   .|:|::...:..
Mouse  2696 TPRAILTGHDYEITCAAVCAELGLVLSGSQEGPCLIHSM-NGDLLRTLEG---PENCLKPKLIQA 2756

  Fly  2638 SYHGHIAFSALDDTSHSVHVYSINGC----SLGSKYVSG-------RVTGLASASDYLVVADDAG 2691
            |..||..            ::..|||    |:..|..:.       |...|:....||:...|.|
Mouse  2757 SREGHCV------------IFYENGCFCTFSVNGKLQATVETDDHIRAIQLSRDGQYLLTGGDNG 2809

  Fly  2692 DITMSRLHGLKPVFDIP 2708
            .:.:.::..||.:|..|
Mouse  2810 VVIVRQVSDLKQLFAYP 2826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605	16/119 (13%)
		DUF4704	906..1162	CDD:292415	56/278 (20%)
		DUF4800	1650..1899	CDD:292675	81/583 (14%)
		PH_BEACH	1952..2046	CDD:275391	29/109 (27%)
		Beach	2072..2351	CDD:280327	170/278 (61%)
		WD40	<2428..2734	CDD:225201	81/313 (26%)
		WD40 repeat	2465..2503	CDD:293791	14/37 (38%)
		WD40	2468..2687	CDD:295369	63/240 (26%)
		WD40 repeat	2509..2580	CDD:293791	18/81 (22%)
		WD40 repeat	2585..2621	CDD:293791	13/35 (37%)
Lrba	XP_006502410.1	LamG	229..376	CDD:389952	39/237 (16%)
		DUF4704	446..717	CDD:374111	63/323 (20%)
		DUF1088	1882..2061	CDD:368928	48/200 (24%)
		PH_BEACH	2087..2184	CDD:373333	27/102 (26%)
		Beach	2216..2492	CDD:366934	170/278 (61%)
		WD40 repeat	2608..2644	CDD:293791	12/35 (34%)
		WD40	<2613..2813	CDD:392136	64/244 (26%)
		WD40 repeat	2650..2703	CDD:293791	18/81 (22%)
		WD40 repeat	2708..2743	CDD:293791	13/35 (37%)
		WD40 repeat	2748..2777	CDD:293791	8/40 (20%)
		WD40 repeat	2784..2824	CDD:293791	8/39 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1787
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820