DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and Wdfy3

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_006535283.1 Gene:Wdfy3 / 72145 MGIID:1096875 Length:3527 Species:Mus musculus


Alignment Length:3279 Identity:714/3279 - (21%)
Similarity:1159/3279 - (35%) Gaps:1036/3279 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 ELLPA----IGKFIIVARDVCETEGKLEE-QAIEEVAILVDCLVIVCRHF------DNILSIIKY 120
            ||.||    ...|::....|.:..||... :.|:..|:|.:..:....:|      |.|.:|...
Mouse   349 ELKPAGVTTGAPFLLPGFAVPQPAGKGHSVRNIQAFAVLQNAFLKAKTNFLAQIILDAITNIYMA 413

  Fly   121 EYKPNLIAILSRVFKQQMELPQSVPAISHLFSSFSAFLEVMYDPYLTWRSFVRGQSADYSRLSYK 185
            :.....|........|..|....:|.:.:.:.....|: |....|:..:..:     ..|.|...
Mouse   414 DNANYFILESQHTLSQFAEKISKLPEVQNKYFEMLEFV-VFSLNYIPCKELI-----SVSILLKS 472

  Fly   186 PHSVHVEIV-----------PFIY-DCFQEEKLI--------RYA-----------EIGESLLNI 219
            ..|.|..|:           .:|: |.|:|..|:        :||           |.|:|..| 
Mouse   473 SSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLLHKYAALLKDPAQALNEQGDSRNN- 536

  Fly   220 LGAVICGSQLQLKVQKSLNSTSTLTNRNTN-------------------------ALTTSSLAPC 259
             .:|.....|.|.|.::|  |..|...|||                         ||.|......
Mouse   537 -SSVEDQKHLALLVMEAL--TVLLQGSNTNAGIFREFGGARCAHNIVKYPQCRQHALMTIQQLVL 598

  Fly   260 SGDGLLDCDNLRNGMKAICPATVSITMSILR--------QWESANNLRRVALQCYALMVIVLQK- 315
            |.:|..|...|...|.:..|..:.:...|||        ...|....|:|....|...::|..: 
Mouse   599 SPNGEDDMGTLLGLMHSAPPTELQLKTDILRALLSVLRESHRSRTVFRKVGGFVYITSLLVAMER 663

  Fly   316 --SSPEERQIDLVTLVQ-------LYCD---ALQELLATKHFDSGDANFDITSDADQDVAI--DM 366
              |||.:...:.|:..|       ::|.   ||:...|..||...:..::..:||.:.:..  |:
Mouse   664 SLSSPPKNGWEKVSQSQVLELLHTVFCTLTAALRYEPANSHFFKTEIQYEKLADAVRFLGCFSDL 728

  Fly   367 AALSSTVAAVKFFVTG---------DAGVS-EAVSDS--NLLELLTNLPKLIKPWHISHSSSL-- 417
            ..:|    ||..|.:.         :..|| ::||.:  :..:|...|.|:......||:..:  
Mouse   729 RKIS----AVNVFPSNTQPFQRLLEEGAVSVDSVSPTLRHCSKLFIYLYKVATDSFDSHAEQIPP 789

  Fly   418 CSTMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSPTV---ELLDTCFMLGYDESEHFLLL 479
            |.|.|:    :..||.....|.:........::...|.:..|   :|..|...|  ..|:..::.
Mouse   790 CLTSES----SLPSPWGTPALSRKRHAFHCVSTPPVYPAKNVTDLKLQVTSSPL--QSSDAVIIH 848

  Fly   480 PEVMLRLLNW---VPTLQERE-----QLHVTSLVLKGCTDNYRTKTVAC--GSHI-IKAVCGCLL 533
            |..||.:|:.   |.::.:.|     ||.|.: :|:......|.:.|.|  |.|. :...||..|
Mouse   849 PGAMLAMLDLLASVGSVTQPEHALDLQLAVAN-ILQSLVHTERNQQVMCEAGLHARLLQRCGAAL 912

  Fly   534 TAESLAENCVQNLIKLIEELSKLSIVPAELKCIF-------------SLLRQ----GTKFPQFKQ 581
            ..|.  .:....|.::.|.|:..::.|..|:...             .||:|    ......|:.
Mouse   913 ADED--HSLHPPLQRMFERLASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSFEP 975

  Fly   582 LQQTLVVIALQSLRGSNSCAEF--------FSIEQPTDGILVP--------------DIRNWTIS 624
            ..::.|:.:|:.|...|..:..        .|:.:..:|..||              |||   :.
Mouse   976 EMRSSVITSLEGLGSDNVFSSHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIR---LH 1037

  Fly   625 GSYGFIFHILVRFNQLKE----------------QSNSRRMLLT---LQTASGSGFEVFVQPNG- 669
            ||  .:....|.|:...|                .:|:....||   :.:..|||...|..|:| 
Mouse  1038 GS--SVTPAFVEFDTSLEGFGCLFLPSLAPHNAPTNNTVTTGLTDGAVVSGMGSGERFFPPPSGL 1100

  Fly   670 ----------------NVVVAALT--RR-------------------EYLTSSTATKTL------ 691
                            |..|..||  ||                   ..|..||..:.|      
Mouse  1101 SYSCWFCIEHFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKDRSLIVSTKEELLQNYVDD 1165

  Fly   692 -----------------------MDGQWHYLTVAITPPKRPFSYSQINIYVDFVQKLSATLKVQA 733
                                   ::||||:|  |:...:.....|...:|:|  .:|.:|:|:..
Mouse  1166 FSEESSFYEILPCCARFRCGELVVEGQWHHL--ALLMSRGMLKNSTAALYLD--GQLVSTVKLHY 1226

  Fly   734 V----------NEPFTVCSIGAVVAPPQPGEVA----KTGN-------MPRSS---SQESG---- 770
            |          |.|........|..||...::|    :.|.       :|.||   ..|.|    
Mouse  1227 VHSTPGGSGSANPPVLSTVYAYVGTPPAQRQIASLVWRLGPTHFLEEVLPPSSVTTIYELGPNYV 1291

  Fly   771 -----------SSGYKGMLPSLLERTLSANVS-NYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQ 823
                       .:..:|:.||.:.......|| ..:.|.:.:.|.  ..::.....:......:|
Mouse  1292 GSFQAVCVPCKDAKSEGVTPSPVSLVAEEKVSFGLYALSVSSLTV--ARIRKVYNKLDSKAIAKQ 1354

  Fly   824 TCLNGHLGGVLLADPTTSLKTIFDAGANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIP 888
            ..::.|       :..|.:|.:.:|..:.                           :|..:.:  
Mouse  1355 LGISSH-------ENATPVKLVHNAAGHL---------------------------NGPARTI-- 1383

  Fly   889 GGKYPGRINAQHCKIVKIQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSA 953
            |....|.:..:......:..|:..|||.:|||.:      :...:|:.....:.::|.|      
Mouse  1384 GAALIGYLGVRTFVPKPVATTLQYIGGAAAILGL------VAMASDVEGLYAAVKALVC------ 1436

  Fly   954 EEFTDWEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSL 1018
                   ::.||          ||||             ...|::...:.||    ||.:...||
Mouse  1437 -------VVKSN----------PLAS-------------KEMERIKGYQLLA----MLLKKKRSL 1467

  Fly  1019 FDVNALMATHLLMESL-QGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYL------S 1076
            .:.:.|..|..|:.:: .||:......  ...:..::.||.:|....:::.|...::.      |
Mouse  1468 LNSHILHLTFSLVGTVDSGHETSIIPN--STAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTES 1530

  Fly  1077 AMIKNDRKFFRKRYGVQFVLDVVRQYYSTPDSISDDDAKTIRATLFGIIKFYLQKDVNIKEVNSM 1141
            :....:.|..|:...:..:|..:|....:..:|         |.:..::.|.||...|..::...
Mouse  1531 SEASKNAKLMREFQLIPKLLLTLRDMSLSQPTI---------AAISNVLSFLLQGFPNSNDLLRF 1586

  Fly  1142 ITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQ--------------SANLL----- 1187
            ..|::|.           :.||.|    |:..:|:.::..:              ||||:     
Mouse  1587 GQFISST-----------LPTFAV----CEKFVVMEINNEEKPDPGAEEEFGGLVSANLILLRNR 1636

  Fly  1188 ---------YN-------------------------FFVDKSYSNEIQEAAIRFISGLLATSRVH 1218
                     |.                         .|:::........||:|.:..||:...:.
Mouse  1637 LLDILLKLVYTSKEKTNINLQACEELVRTLGFDWIMMFMEEHLHPTTVTAAMRILVVLLSNQSIL 1701

  Fly  1219 QKYKQVLR---LYDQT------------------------------TEQSMFPGFF---SFITPL 1247
            .|:|:.|.   ..:||                              .:...||||.   ||: |.
Mouse  1702 IKFKEGLSGGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFLVLQSFL-PK 1765

  Fly  1248 SLSSTILFHLVDEMLGLQPDYAGLIFLVYHVSSCDLPVKLEIAKRLLQT--------------TF 1298
            ..:...|:.|:..:...||           ||  :||..|:::..:..:              ||
Mouse  1766 HTNVPALYFLLMALFLQQP-----------VS--ELPENLQVSVPVTSSRCKQGCQFDLDSIWTF 1817

  Fly  1299 V----KQQSTVAMAKQTGWQESIARLL-IRKPITSSPPDEEKRRSFGINLDVLLEDNSNFLAQAD 1358
            :    ....||..:......||...|| :.:.:.:||...|:..|:                   
Mouse  1818 IFGVPASSGTVVSSIHNVCTESAFLLLGMLRSMLNSPWQSEEEGSW------------------- 1863

  Fly  1359 LITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESEIKELAESVSGAVVENANSL 1423
               ..|..:.|.|..:.....:.|...:..........||||....|:..:|.|:          
Mouse  1864 ---LREYPVTLMQFFRYLYHNVPDLASMWLSPDFLCALAATVFPFNIRPYSEMVT---------- 1915

  Fly  1424 FSVIRQTTHDLQDTFESLTQGSSTDTADGSQTPSIQREESLSSDTSSQSPHGPPKKSDSLESTSA 1488
                     ||.|...|..:......||.....|  :.|..:..|.:...:.|.||       ..
Mouse  1916 ---------DLDDEVGSPAEEFKAFAADTGMNRS--QSEYCNVGTKTYLTNHPAKK-------FV 1962

  Fly  1489 FDFVADGDVDTEEQLVYLVSN----------TLFNIFWRGIPNDHPQCWQERGQVLGCINLLALN 1543
            |||:.          |.::.|          .|.::.....|....:..|:..|.    ::|   
Mouse  1963 FDFMR----------VLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQKEFQT----HVL--- 2010

  Fly  1544 NELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVNQENASHILRMVYELVVLGSNEDESKKCST 1608
             :.:..|| |...:| :...|||...|....|.|||  |..:..:.|.:.:..|....|||    
Mouse  2011 -DSVMDHL-LAADVL-LGEDASLPITSGGSYQVLVN--NVFYFTQRVVDKLWQGMFNKESK---- 2066

  Fly  1609 KLLDGVLALLDALMIFQQGSSDDWSDMIRLCLG--LLLKCS--HHPNPGIVAMATAKLHAILQSR 1669
            .|:|.::.|:.......||.|   .|.:..||.  :|.:.|  |...|..||:..          
Mouse  2067 LLIDFIIQLIAQSKRRSQGLS---LDAVYHCLNRTILYQFSRAHKTVPQQVALLD---------- 2118

  Fly  1670 STEDPAELSYLLYSINRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLDSTLPD-------- 1726
                    |..:.::||.|  .:..||.:: .|:     :.|..|.:..:..|::..        
Mouse  2119 --------SLRVLTVNRNL--ILGPGNHDQ-EFI-----SCLAHCLINLHAGSSVEGFGLEAEAR 2167

  Fly  1727 -------LPS-----------TSSGPVFFNDFQMYSTSKKW-------RNFIERMVK---PLYDR 1763
                   :||           .|.|    ....:.:.::.|       :..:|.:.|   |:.||
Mouse  2168 MTTWHIMIPSDIEPDGGYSQDISEG----RQLLIKAVNRVWTELIHSKKQVLEELFKVSLPVNDR 2228

  Fly  1764 YQRDIELHLWEP-INRFWAECYEACKAASKQ--------------------------RATNQAEN 1801
            ...||.|.  .| |.....:|::...|..|:                          :.|....|
Mouse  2229 GHVDIALA--RPLIEEAGLKCWQNHLAHEKKCISRGEALVPTTQSKLSRVSSGFGLSKLTGSRRN 2291

  Fly  1802 RRLFQQKIYMP-------WK------VR-----QVEEMQRLQAAALQHKTIDSHIRKRWKTAKRF 1848
            |:......:.|       |.      ||     |.:|.|..|..||::.|      :.|...:..
Mouse  2292 RKESGLHKHSPSPQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVT------EEWCQIECE 2350

  Fly  1849 LYGPRGPW---YTGEVDEEFWKLSQHENVARMRLKL----------------------------- 1881
            |...||.|   ....:|:  |.|...|...|||.|:                             
Mouse  2351 LLRERGLWGPPIGSHLDK--WMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQEASVGSEIPSK 2413

  Fly  1882 --EP------QLYPNKHENAANLRDNATSAYDTKE-----ISEFDSTIKNAVVRDFLADDESSQL 1933
              ||      |..|.::..|.        :||:||     .|...:.:::|:|..  ::.|::|.
Mouse  2414 QPEPPDDVIAQKKPARYRRAI--------SYDSKEYYLRLASGNPAIVQDAIVES--SEGEATQQ 2468

  Fly  1934 E------------------------------EELRQLIDTQAQQDVALEKLVMSQDCELITLM-- 1966
            |                              ||.::.:..|..:..::|:...:.:..|:.|:  
Mouse  2469 EPEHGEDTIAKVKGLVKPPLKRSRSAPDGGDEETQEQLQDQIAESGSIEEEEKTDNATLLRLLEE 2533

  Fly  1967 ----------TKVKGRIEVNQSVFTF---------------------VDLSPP----------TE 1990
                      .:|:| ::.::.:..|                     ::..||          ..
Mouse  2534 GEKIQHMYRCARVQG-LDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPPNMHEPIIPRGAR 2597

  Fly  1991 DGSKYDFR----FSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGL--- 2048
            .|.....|    |:...|:|||.|:|.|:..|:|:|..|..:|.|.|....||||:.:.:.:   
Mouse  2598 QGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQKGIRNKVYQRFLAVVPS 2662

  Fly  2049 ------------PLPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQ 2101
                        |..::..|||.. :.|:....:||||...|||||:|||:|||:||||||||.|
Mouse  2663 LTDSSESVSGQRPNTSVEQGSGLL-STLVGEKSVTQRWERGEISNFQYLMHLNTLAGRSYNDLMQ 2726

  Fly  2102 YPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHY 2166
            ||||||||:||.|:.:|||:||:||:|:||:|....:..|:.:.:|..:|||:|..|.:||||||
Mouse  2727 YPVFPWILSDYDSEEVDLTNPKTFRNLAKPMGAQTDERLAQYKKRYKDWEDPNGETPAYHYGTHY 2791

  Fly  2167 SNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTW-KLLMDNPNDVKELIPEFFYFPE 2230
            |::..|..||:|:||||.:.:.||.|.||:|||.|||:.:.| .....|..|||||||||||.||
Mouse  2792 SSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWYSASKHNMADVKELIPEFFYLPE 2856

  Fly  2231 FLKNMNKFDLGHLQITKEKVDDVILPAWAT-TPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQ 2294
            ||.|.|.||||..| ...|:.|||||.||. .|.|||.:||.|||.:|||.|||.||||||||||
Mouse  2857 FLFNSNNFDLGCKQ-NGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQ 2920

  Fly  2295 KGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHP-----RRLTQ 2354
            :||.|.||:|||::..|||.||:..|.:|::..|..|.||||||:|.||.::|||     .||..
Mouse  2921 QGPAAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSRLNG 2985

  Fly  2355 DETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSPPR--SPPRSFLQLSPDVLVSIS 2417
            |...:.:      .|..|.  ||:..::.:...|.     |:|.:  ..|...:..:...::::.
Mouse  2986 DNIGISV------PPGATS--DKIFFHHLDNLRPS-----LTPVKELKEPVGQIVCTDKGILAVE 3037

  Fly  2418 KSTILGCNSWLSFDKD--QGFLLEIDATTANLKNRKRIFGPFHSSQ---------QPHSQLFAVS 2471
            ::.:|...:|   :|.  .|:        |:|..|   .|.:.|.:         :....|.||.
Mouse  3038 QNKVLIPPAW---NKTFAWGY--------ADLSCR---LGTYESDKAVTVYECLSEWGQILCAVC 3088

  Fly  2472 TDGKLLYAGG------IWDNSLRVYNLNKGKA-----VASVTRHLDIITCIALDNCGSYLVTGSR 2525
            .:.||:..||      :|:     ...:|.||     ..::..|.|.:||.........:|:|||
Mouse  3089 PNPKLVITGGTSTVVCVWE-----MGTSKEKAKPLTLKQALLGHTDTVTCATASLAYHIIVSGSR 3148

  Fly  2526 DCTCIVW-----SIQTNQQGGGSTNNIPVHA-----LTGQ--------SHL-----QAITQLNTQ 2567
            |.|||:|     |..|..:|    :..||.|     |||.        .|:     ..|..:||.
Mouse  3149 DRTCIIWDLNKLSFLTQLRG----HRAPVSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTF 3209

  Fly  2568 NSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKP---------I 2623
            ...|.:.:..      .:|.:..:...:::|:|..||.|..:.::..|...|..|         .
Mouse  3210 TGRSQQIVCC------CMSEMNEWDTQNVIVTGHSDGVVRFWRMEFLQVPETPAPEPVEDLEMQE 3268

  Fly  2624 GCTESCVQISFVTLSYHGHIAFSALDDTS 2652
            ||.|:             .|...|.||.|
Mouse  3269 GCPEA-------------QIGQQAQDDDS 3284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 37/188 (20%)
DUF4704 906..1162 CDD:292415 45/262 (17%)
DUF4800 1650..1899 CDD:292675 63/369 (17%)
PH_BEACH 1952..2046 CDD:275391 29/140 (21%)
Beach 2072..2351 CDD:280327 164/285 (58%)
WD40 <2428..2734 CDD:225201 62/279 (22%)
WD40 repeat 2465..2503 CDD:293791 11/48 (23%)
WD40 2468..2687 CDD:295369 54/228 (24%)
WD40 repeat 2509..2580 CDD:293791 25/93 (27%)
WD40 repeat 2585..2621 CDD:293791 8/35 (23%)
Wdfy3XP_006535283.1 DUF4704 1392..>1554 CDD:374111 36/209 (17%)
PH_BEACH 2535..2658 CDD:275391 26/123 (21%)
Beach 2697..2977 CDD:366934 164/280 (59%)
WD40 repeat 3046..3073 CDD:293791 8/40 (20%)
WD40 <3067..3248 CDD:392136 45/195 (23%)
WD40 repeat 3085..3126 CDD:293791 10/45 (22%)
WD40 repeat 3132..3168 CDD:293791 13/35 (37%)
WD40 repeat 3173..3210 CDD:293791 9/36 (25%)
WD40 repeat 3217..3252 CDD:293791 6/40 (15%)
FYVE_WDFY3 3450..3514 CDD:277259
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1786
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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