DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and NBEAL1

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_006712761.1 Gene:NBEAL1 / 65065 HGNCID:20681 Length:2736 Species:Homo sapiens


Alignment Length:2902 Identity:956/2902 - (32%)
Similarity:1522/2902 - (52%) Gaps:354/2902 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDNKKDIYNLWVQYTTKNDETHFRQFVARFVAIWRSQLQLDFQAENCPMWHEVQPDSGPHLGRLP 65
            |.:::.::.||:.|.||.|..:.:.::..||:.:...|.:||  |..|...:..|   |.:..||
Human     1 MASRERLFELWMLYCTKKDPDYLKLWLDTFVSSYEQFLDVDF--EKLPTRVDDMP---PGISLLP 60

  Fly    66 DELLPAIGKFIIVARDVCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKYEYKPNLIAIL 130
            |.:|..:.  |.:.:.|.:....||||......:||...:|:||:..|:..|....| .|.:..:
Human    61 DNILQVLR--IQLLQCVQKMADGLEEQQQALSILLVKFFIILCRNLSNVEEIGTCSY-INYVITM 122

  Fly   131 SRVFKQQMELPQ------SVPAISHLFSSFSAFLEVMYDPYLTWRSFVRGQ---SADYSRLSYKP 186
            :.::.||::..:      ....|........||.|.:||||..||..:.|:   :.:.||..|||
Human   123 TTLYIQQLKSKKKEKEMADQTCIEEFVIHALAFCESLYDPYRNWRHRISGRILSTVEKSRQKYKP 187

  Fly   187 HSVHVEIVPFIYDCFQEEKLIRYAEIGES----LLNILGAVICGSQLQLKVQKSLNSTSTLTNRN 247
            .|:.||.|||.|.||||.:.::     ||    ||::.||::.|.|                   
Human   188 ASLTVEFVPFFYQCFQESEHLK-----ESLKCCLLHLFGAIVAGGQ------------------- 228

  Fly   248 TNALTTSSLAPCSGDGLLDCDNLRNGMKAICPATVSITMSILR---QWESAN-----NLRRVALQ 304
                                   ||.::||.|||:.:.|.:|.   .||..:     ....:.|:
Human   229 -----------------------RNALQAISPATMEVLMRVLADCDSWEDGDPEEVGRKAELTLK 270

  Fly   305 CYALMVIVLQKSSPEERQIDLVTLVQLYCDALQE-------------------LLATKHFDSGDA 350
            |...:|.:|..|:.::||::..|:::.|...|..                   .|..|..::..|
Human   271 CLTEVVHILLSSNSDQRQVETSTILENYFKLLNSDHSALPNQRRSRQWENRFIALQIKMLNTITA 335

  Fly   351 NFDITSDADQDV--AIDMAA-----LSSTVAAVKFFVTGDAGVSEAVSDSNLLELLTNLPKLIKP 408
            ..|.|   |:.|  ||.:.:     |...:...|.|:    ..:..|:|.|..:|...|...:..
Human   336 MLDCT---DRPVLQAIFLNSNCFEHLIRLLQNCKLFL----NANNKVADKNEKDLANKLLTEMNE 393

  Fly   409 WHISHSSSLC---STMEALAILARHSPQSASQLRQGERIERLFTSLQEYGSPTVELLDTCFMLGY 470
            ..:......|   ||::||..:...||.:....::......:...|:..|.|.:|||.....:..
Human   394 DQVFQGQLDCLAISTIQALTAVMNKSPAAKEVFKERIGYTHMLEVLKSLGQPPLELLKELMNMAV 458

  Fly   471 DESEH----FLLLPEV--MLRLLNWVPTLQERE-QLHVTSLVLKGCTDNYRTKTVACGSHIIKAV 528
             |.:|    .|.:..|  :|.|:.|:|.||..: |:.::..:.:.|..|.:::|....:::...:
Human   459 -EGDHTSVGILGISNVQPLLLLIQWLPELQSHDLQIFISDWLKRICCINRQSRTTCVNANMGIRI 522

  Fly   529 CGCLLTAESLAENCVQNLIKLIEELSKLSIVPAELKCIFSLLR---QGTKFPQFKQLQQTLVVIA 590
            ...|....||.:.|.:|||.:...|...|:...|::.:..|||   ..:..|....:.:.::.:|
Human   523 IETLDLHSSLHQTCAENLIAIHGSLGSQSVSSEEIRRLLRLLRVDESESVHPYVTPVTRAILTMA 587

  Fly   591 LQ-SLRGSNSCAEFFSIEQPTDGILVPDIRNWTISGSYGFIFHILVRFNQL----KEQSNSRRML 650
            .: ||   .|..::|::.....||.||.|:.|. ..::.|.....:..:||    ..:...|:.|
Human   588 RKLSL---ESALQYFNLSHSMAGISVPPIQKWP-GSAFSFSAWFCLDQDQLTLGIANKGGKRKQL 648

  Fly   651 LTLQTASGSGFEVFVQPNGNVVVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPKRPFSYSQI 715
            .:..|.||.|||.|:..:|.:|||..|:|||.|......:..|..||.:||...|.||||..|.:
Human   649 YSFFTGSGMGFEAFITHSGMLVVAVCTKREYATVMLPDHSFCDSLWHNITVVHMPGKRPFGQSFV 713

  Fly   716 NIYVDFVQKLSATLKVQAVNEPFTVCSIGAV---VAPPQPGEVAKTGNMPRSSSQESGSSGYKGM 777
            .||.:..||:||.|:..|:|||||.|.||:.   ...|.|.::.   :.|.||......:.:.|:
Human   714 YIYDNGQQKVSAPLRFPAMNEPFTSCCIGSAGQRTTTPPPSQIP---DPPFSSPITPHRTSFGGI 775

  Fly   778 LPS-----------LLERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLG 831
            |.|           |:.:.:||                         |.||:.:|..|.|.|.||
Human   776 LSSASWGGTIEKSKLITKLISA-------------------------GTQDSEWGCPTSLEGQLG 815

  Fly   832 GVLL-ADP--TTSLKTIFDAGANFSSIFS-QDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKY 892
            .|:: .:|  ...:|.::.||.|..|.:. |::|:.:|....:..|...|..:..|.||.....:
Human   816 SVIIFYEPLQPPQVKALYLAGPNCLSPWKCQESDMADLPGNILLYYTAKACKNSICLDLSTNCLH 880

  Fly   893 PGRINAQHCKIVK--IQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEE-SLSCAPTPSAE 954
             ||:...  |:|.  |::.||.|||::.:.|:      |:|.:..|.|.:.|| :.|..|.....
Human   881 -GRLTGN--KVVNWDIKDIINCIGGLNVLFPL------LEQISHFSEGQIPEEKNESTVPESVTP 936

  Fly   955 EFTDWEMLSSNSYTEWKMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLF 1019
            ...||.:.:|...:|.::.::.:|:|:.::::....|..||..|:.|..:|.:|.:||:.|.:|.
Human   937 VEGDWLVWTSTKASESRLERNLVATFILIVKHFIQRHPINQGNLIHSHGVATLGALLQKVPSTLM 1001

  Fly  1020 DVNALMATHLLMESLQGHKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRK 1084
            |||.|||..||:|.:   ..|...|||..:|.:::|||.||:|..|...:||.||||.:||:.|:
Human  1002 DVNVLMAVQLLIEQV---SLEKNMQLLQQMYQYLLFDFRIWNRGDFPFRIGHIQYLSTIIKDSRR 1063

  Fly  1085 FFRKRYGVQFVLDVVRQYYSTP---DSISDDDAKTIRATLFGIIKFYLQKDVNIKEVNSMITFLA 1146
            .|||:|||||:||.:|.||...   :.:|.||.:|||.:|:|:||::|.|..:.:|:.|::.::|
Human  1064 VFRKKYGVQFLLDTLRIYYGNGCKYNELSLDDIRTIRTSLYGLIKYFLCKGGSHEEIQSIMGYIA 1128

  Fly  1147 SVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSANLLYNFFVDKSYSNEIQEAAIRFISGL 1211
            :..::..|...|:::...:|....:.|:.|||.||.:|::||...:::.||:.::|...:.:..:
Human  1129 ATNEEEQLFGILDVLFSLLRTSPTRGQLFLLLFEPGNADILYALLLNQKYSDRLREIIFKIMEQM 1193

  Fly  1212 LATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTILFHLVDEMLGLQP--DYAGLIFL 1274
            |..:.|:::.||.:||     .:..:.|....:....::::::.:|..:::...|  ::..|:.:
Human  1194 LKCTNVYERSKQHIRL-----REVGYSGLGLLLNEALVNTSLIKNLTHQIINTDPVINFKDLLSV 1253

  Fly  1275 VYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESIARLLIRKPITSSPPDEEKRRSF 1339
            ||......:.|::.|.:::||....:..:...:::|.|||:::.||.::....:.....:..|: 
Human  1254 VYISHRAHINVRVAICRKVLQILQFQPDAAHQISQQVGWQDTLVRLFLKAKFENGNTLHKHSRA- 1317

  Fly  1340 GINLDVLLEDNSNFLAQADLITFSEQEIGLAQLQQQQQEELSDSGLILNEIQASVTEAATVIESE 1404
                 ||::||...::..|              .::..:|.:|...|.:...|:|:.....:|..
Human  1318 -----VLMKDNDKNMSTED--------------TKKNSDEKTDEEKITSFASANVSSDQWSLEDR 1363

  Fly  1405 IKELAESVSGAVVENANSLF---SVIRQTTHDLQDTFESLTQGSSTDTADGSQTPSIQREESLSS 1466
            ..          :::...||   |.:.:.:...::..|......|..:.|.|...|.:     .|
Human  1364 HS----------LDSNTPLFPEDSSVGELSFKSENQEEFWHSNPSHLSLDLSGIDSCE-----MS 1413

  Fly  1467 DTSSQSPHGPPKKSDSLESTSAFDFVADGDVD-------------------TEEQLVYLVSNTLF 1512
            |:.||.|...|.....:|||.:|...:|.:..                   .||:|:.|:::.|.
Human  1414 DSGSQVPDSLPSTPSPVESTKSFSVHSDRESSITNDMGFSDDFSLLESQERCEEELLQLLTHILN 1478

  Fly  1513 NIFWRGIPNDHPQCWQERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTL 1577
            .:..:|:.......|.|||||...::...:::||:.....::|.:|:..::.::.: :.......
Human  1479 YVMCKGLEKSDDDTWIERGQVFSALSKPGISSELLRPSDEIKLTLLQKMLEWAISE-NREAKTNP 1542

  Fly  1578 VNQENASHILRMVYELV----VLGSNEDESKKCSTKLLDGVLALLDALMIFQQGSSDDWSDMIRL 1638
            |..|||..::.::.:.:    ::.||     ..:.|||:.::.|.|.|.:. ...|..|..:.::
Human  1543 VTAENAFRLVLIIQDFLQSEGLVNSN-----MWTEKLLEDMMLLFDCLSVC-YSESPVWVKLSQI 1601

  Fly  1639 CLGLLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSINRALDNAIEVGNPEEYSFL 1703
            .:.|||......|..:.|||:|||:.:||::..|:..|..|:|..:...|..:|: ...|.||||
Human  1602 QIQLLLGFIGRGNLQVCAMASAKLNTLLQTKVIENQDEACYILGKLEHVLSQSIK-EQTEIYSFL 1665

  Fly  1704 MPVMKALLEKCRVAFNLDSTLPDLPSTSSGPVFFNDFQMYSTSKKWRNFIERMVKPLYDRYQRDI 1768
            :|:::.|:.|......::..||.||.|:....||.|||.|..|.:|:.:||:.:.|    |.:..
Human  1666 IPLVRTLVSKIYELLFMNLHLPSLPFTNGSSSFFEDFQEYCNSNEWQVYIEKYIVP----YMKQY 1726

  Fly  1769 ELHLW----EPINRFWAECYEACKAASKQRATNQAENRRLFQQKIYMPW--KVRQ--------VE 1819
            |.|.:    |.:..:|.:||||......:|.....|::..||:....|:  |.||        ::
Human  1727 EAHTFYDGHENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLRYNNMLK 1791

  Fly  1820 EMQRLQAAALQHKTIDSHIRKRWKTAKRFLYGPRGPWYTGEVDEEFWKLSQHENVARMRLKLEPQ 1884
            ::...|.|.|          :|||..:.:|...||||...:.:...|||:..||.:||||||.|.
Human  1792 QLSSQQLATL----------RRWKAIQLYLTCERGPWAKRKQNPIHWKLANVENYSRMRLKLVPN 1846

  Fly  1885 LYPNKHENAANLRDN-----ATSAYDTKEISEFDSTIKNAVVRDFLADDESSQLEEEL--RQLID 1942
            .....||.|:.||||     :..:.||..:    ..:|...|.| :.:|:....||::  |..:|
Human  1847 YNFKTHEEASALRDNLGIQHSQPSSDTLLL----EVVKQVKVSD-MVEDKLDLPEEDITARVNVD 1906

  Fly  1943 TQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSKYDFRFSTNKIREV 2007
            .:.:|| ..||||:.:||||||::..:.||:|:......|.|.|...|||..:||::..::|||:
Human  1907 EKEEQD-QKEKLVLMEDCELITIIDVIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHSQIREI 1970

  Fly  2008 HLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTKIVGLPLPNILYGSGRSPAELLRASGLTQ 2072
            |||:|||||||||||.|||::|||||..:.|||::::::.|..||..||| |||.||.:||||||
Human  1971 HLRRYNLRRSALEIFHVDQSNYFLNFKKEVRNKIYSRLLSLHSPNSYYGS-RSPQELFKASGLTQ 2034

  Fly  2073 RWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINP 2137
            :|:|||||||:||:.:||:|||:||||:|||||||||.||||:.|||.:|..|||||||||.:|.
Human  2035 KWVNREISNFDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNE 2099

  Fly  2138 KNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFH 2202
            ||...:|.||::||||.|.|.||||||||||||||:|||:||||||:|||.|||||||.||||||
Human  2100 KNAKAMREKYENFEDPMGTIDKFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQFH 2164

  Fly  2203 SIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWATTPEEFIA 2267
            |||.||:.|||||.||||||||||||||||:|.|:|:||.|||:||.|:|||||.||.:.|:||.
Human  2165 SIPATWQALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWAKSAEDFIY 2229

  Fly  2268 IHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGM 2332
            .||:||||||||.|||.||||||||||:||.|.||||||||||||||||||.:|:..||:|:|||
Human  2230 KHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLDALTDEKERKALEGM 2294

  Fly  2333 INNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQYYCELSTPKDPIVYLSP 2397
            ||||||.|.|||:||||.||:.:|...|..:.:....:|.|.|.::..::.|..:...|::..:.
Human  2295 INNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPELKSFFIEGISDGIPLLKATI 2359

  Fly  2398 PRSPPRSFL-QLSPDVLVSISKSTILGCNSWLSFDKD--QGFLLEIDATTANLKNRKRIFGPFHS 2459
            |::..|||: |.||::|::||.:.::|.:.||.:|::  ..|....|.|..|.|.::.|.|.|..
Human  2360 PKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNYFTFIKDQTVTNPKTQRSINGSFAP 2424

  Fly  2460 SQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNLNKGKAVASVTRHLDIITCIALDNCGSYLVTGS 2524
            ..:..|:||.||.|.|||::.|.||||::|.:|.|||.::.:.||:||:||:|.|.||.:|::||
Human  2425 GLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKGKIISHIIRHMDIVTCLATDYCGIHLISGS 2489

  Fly  2525 RDCTCIVWSIQTNQQGGGSTNNIPVHALTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVA 2589
            ||.||::|  |..||||     :||                   ..:.||..:||||.:.:.||.
Human  2490 RDTTCMIW--QITQQGG-----VPV-------------------GLASKPFQILYGHTNEVLSVG 2528

  Fly  2590 IYTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESC-VQISFVTLSYHGHI-AFSALDDTS 2652
            |.||||:.||||.||||.::|:|:||::|||:| .|..|. :.|..:.:|:.||| .:|:.::.:
Human  2529 ISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRP-PCESSLFLTIPNLAISWEGHIVVYSSTEEKT 2592

  Fly  2653 -----HSVHVYSINGCSLGSKYVSGRVTGLASASDYLVVADDAGDITMSRLHGLK-PVFDIPLHV 2711
                 :::|::||||..|||:.:..:|:.:....:::|.....|.:::..||.|. .:..:.:.:
Human  2593 TLKDKNALHLFSINGKYLGSQILKEQVSDICIIGEHIVTGSIQGFLSIRDLHSLNLSINPLAMRL 2657

  Fly  2712 PIQTVVVTPGNTHILAPLRDGRLAVIAVQLPSGGNKKHSVLN 2753
            ||..|.||...:|||..|.||:|.|:.|..|:  ..|.|:.|
Human  2658 PIHCVCVTKEYSHILVGLEDGKLIVVGVGKPA--EVKPSISN 2697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 46/111 (41%)
DUF4704 906..1162 CDD:292415 92/259 (36%)
DUF4800 1650..1899 CDD:292675 84/262 (32%)
PH_BEACH 1952..2046 CDD:275391 49/93 (53%)
Beach 2072..2351 CDD:280327 209/278 (75%)
WD40 <2428..2734 CDD:225201 116/315 (37%)
WD40 repeat 2465..2503 CDD:293791 19/37 (51%)
WD40 2468..2687 CDD:295369 89/225 (40%)
WD40 repeat 2509..2580 CDD:293791 24/70 (34%)
WD40 repeat 2585..2621 CDD:293791 21/35 (60%)
NBEAL1XP_006712761.1 DUF4704 888..1148 CDD:292415 93/268 (35%)
DUF4800 1609..1862 CDD:292675 85/267 (32%)
PH_BEACH 1915..2012 CDD:275391 49/96 (51%)
Beach 2034..2313 CDD:280327 209/278 (75%)
WD40 <2390..2699 CDD:225201 124/337 (37%)
WD40 repeat 2435..2468 CDD:293791 16/32 (50%)
WD40 2438..2682 CDD:295369 102/270 (38%)
WD40 repeat 2474..2519 CDD:293791 24/70 (34%)
WD40 repeat 2524..2560 CDD:293791 21/35 (60%)
WD40 repeat 2572..2606 CDD:293791 7/33 (21%)
WD40 repeat 2619..2654 CDD:293791 6/34 (18%)
WD40 repeat 2659..2699 CDD:293791 17/41 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 455 1.000 Domainoid score I504
eggNOG 1 0.900 - - E1_KOG1787
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1438 1.000 Inparanoid score I115
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47730
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 1 1.000 - - FOG0003051
OrthoInspector 1 1.000 - - oto91282
orthoMCL 1 0.900 - - OOG6_101577
Panther 1 1.100 - - O PTHR13743
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1767
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.880

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