Protein Alignment CG43367 and WDFY4

DIOPT Version :10

• Sequence 1: NP_001189048.2
• Gene: CG43367 / 38505
• FlyBaseID: FBgn0263110
• Length: 2754
• Species: Drosophila melanogaster
• Sequence 2: XP_054222398.1
• Gene: WDFY4 / 57705
• HGNCID: 29323
• Length: 3224
• Species: Homo sapiens
• Alignment Length: 3312
• Identity: 715/3312 - (21%)
• Similarity: 1195/3312 - (36%)
• Gaps: 1091/3312 - (32%)

  Fly    36 SQLQLDFQ-AENCPMWHEV--------QPDSGPHLGRLPDELLPAIGKFIIVARDVCETEGKLEE 91
            |.|.|:|: :|..|:..:|        |.:..|||    :|||.     ::|....|   |:.|
Human   343 SALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHL----EELLG-----LVVWLTTC---GRSE- 394

  Fly    92 QAIEEVAILVDCLVIVCRHFDNI----LSIIKYEYK------PNLIA--ILSRVFKQQMELPQSV 144
                            .:.||:|    |...|:.::      .||.|  :|..||.:..:....:
Human   395 ----------------LKVFDSITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCI 443

  Fly   145 PAISHL-----FSSFSAFLEVMYDPYLTWRSFVRGQSADYSRLSYKPHSVHVEIVPFIYDCFQEE 204
            ..:|.:     :::.:.||       |.|              :.:|.|..|||:|
Human   444 QVLSVIRTMWAWNARNFFL-------LEW--------------TLQPISQFVEIMP--------- 478

  Fly   205 KLIRYAEIGESLLNILGAVICG---------SQLQLKVQKSLNSTSTLTNRNTNALTTSSLAPCS 260
              ::.|.:.|....:|.|::..         .::|..:::|...:.||       :...|:...:
Human   479 --LKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGPSCTL-------MALQSILSIA 534

  Fly   261 GDGLLDCDNLR-NGMKAICPATVSITMSILRQWESANNLRRVALQ-------CYALMVIV-LQKS 316
            |...|..|..| :|:..:..|.:.....|:|  :|.|.:....:|       |..|.::| |.|.
Human   535 GGDPLFTDIFRDSGLLGLLLAQLRKQAKIMR--KSGNKVSTPGVQDPERELTCVMLRIVVTLLKG 597

  Fly   317 SPEERQI----DLVTLVQLYCD----------ALQELLATKHFDSGDANFDITSDADQDVAIDMA 367
            |.....:    .:|..::::.|          .|::|.|.              :|::.::|.:.
Human   598 SVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAI--------------NAEEYMSIIVG 648

  Fly   368 ALSSTV------------AAVKFFVT--GDAGVSEAVSDSNLLELLTNL------PKLIKPW-HI 411
            ||.|:.            :.::..||  |.|....:...:.||.||::|      |.| :.| .:
Human   649 ALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPL-QAWGAV 712

  Fly   412 SHSSSL---CSTMEALAILARHSPQSASQLRQGERIERL---------FTSLQEYGS-------- 456
            |...:|   ..|:.|::......|.:....|:....|:|         |.:|:|.|:
Human   713 SPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDT 777

  Fly   457 ---PTVELLDTCF---------------MLGY--------------------------------- 470
               |..:||.|.|               :||:
Human   778 KARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDLKESLRTKQGPVVDVQKGE 842

  Fly   471 -------------------DESEHFLLLPEV---MLRLLNWV-----PTLQEREQL----HVTSL 504
                               ||.:..::.|.|   |:|||..:     |.|.|..|.    |:.||
Human   843 TGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQLSEEIQCSLASHIQSL 907

  Fly   505 VLKGCTDNYRTKTVACGSHI---IKAVC-GCLLTAESLAENCVQNLIKLIEELSKLSIVPAELK- 564
            |     .:.:.:.|.|.:.:   :.|.| ..|:|:.|...:   .||::.|:|:..:|.|..|:
Human   908 V-----KSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHS---RLIRIFEKLASQAIEPDVLRQ 964

  Fly   565 ----------------------------CIFSLLRQG------------------TKFPQ----- 578
                                        |..|...||                  |:.||
Human   965 FLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAPDAGLHPGVTQAPQPLGES 1029

  Fly   579 ---FKQLQQTLVVIALQSLRG--------SNSCAEF-FSIEQ------PTDGILVPDIRNWTISG 625
               ...||..|.:|::.|.|.        :.|..|| .|:|.      ||...::.....:::||
Human  1030 QDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSG 1094

  Fly   626 SYG--------------FIFHILVRFNQLKEQSNSRRMLLTLQTASGSG-----FEVFVQPNGNV 671
            ..|              |....|:..:....:.:..|.|..::..:.:.     |.|.:.|:...
Human  1095 GIGTGATRPFPPPGGLTFSCWFLISRHGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLS 1159

  Fly   672 VVAALTRREYLTSST------------------ATKTLMDGQWHYLTVAITPPKRPFSYSQINIY 718
            :|.:...:|:.....                  ..:.|..||||:|.|.:|  |....:..::..
Human  1160 LVVSTEEKEFQPLDVMEPEDDSEPSAGCQLQVRCGQLLACGQWHHLAVVVT--KEMKRHCTVSTC 1222

  Fly   719 VD-FVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLL 782
            :| .|...:..|.:||:..||.                                    .|.||..
Human  1223 LDGQVIGSAKMLYIQALPGPFL------------------------------------SMDPSAF 1251

  Fly   783 ERTLSANVSNYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLGGVLLADPTTSLKT--- 844
                 .:|..|...|                    .|:.:::.|...||...|.:...|::|
Human  1252 -----VDVYGYIATP--------------------RVWKQKSSLIWRLGPTYLFEEAISMETLEV 1291

  Fly   845 IFDAG----ANFSSIFSQDNDLLELNSRFVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIVK 905
            |...|    .||.::..|..||....:.||            .::.:..|.:..  ::....:..
Human  1292 INKLGPRYCGNFQAVHVQGEDLDSEATPFV------------AEERVSFGLHIA--SSSITSVAD 1342

  Fly   906 IQETINSIG--------GISA---ILPML-------HRLITLDQTTDISIGSVSEESLSCAPTPS 952
            |:...|.:.        .||:   .:|:.       |...:|.....:::|.:.......:|..|
Human  1343 IRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAAS 1407

  Fly   953 AEEF--------------TD-----------WEMLSSNSYTEWKMLQHPLASFLC---LLRYLTH 989
            :.:|              ||           ..:|:||:..:: ::||     :|   ::.:|..
Human  1408 SLDFIGGPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDF-LMQH-----ICGYQIMAFLLR 1466

  Fly   990 EHETNQEQLLSSECLAIVGTMLQRCPPSL-FDVNALMATHLLMESLQGHKAEAGGQLLDALYAHI 1053
            :..:.....:....|::.||:      .| |..:|:..|                    .::.||
Human  1467 KKASLLNHRIFQLILSVAGTV------ELGFRSSAITNT--------------------GVFQHI 1505

  Fly  1054 VFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFRK---RYGVQFVLDVVRQYYS---TPDSISDD 1112
            :.:|.:|......:.|....:|..::::.|:..|.   .:..|.:..::..:..   .|..||
Human  1506 LCNFELWMNTADNLELSLFSHLLEILQSPREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKIS-- 1568

  Fly  1113 DAKTIRATLFGIIKFYLQKDVNIKEVNSMITFL------ASVRQDVVLV---------------- 1155
                   |:.||:...|:...:.:::..:..|:      :||.:..:.:
Human  1569 -------TIIGILACQLRGHFSTQDLLRIGLFVVYTLKPSSVNERQICMDGALDPSLPAGSQTSG 1626

  Fly  1156 -------EFLEMMTFYVR------GKNCKDQMVLL-------------LHEPQSA---NLLYNFF 1191
                   :.|||:...:.      ....|::|.|.             ||...:.   .||..|.
Human  1627 KTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLLYFL 1691

  Fly  1192 VDKSYSNEIQEAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLSSTIL-- 1254
            ...|...       ||..||.|.|.|.:..:.|..:.|....||          ||...|..|
Human  1692 ASPSLRT-------RFRDGLCAGSWVERSTEGVDIVMDNLKSQS----------PLPEQSPCLLP 1739

  Fly  1255 -FHLVDEMLGLQPDYAGLIFLVYHVSSCDLP-VKLEIAKRLLQTTFVKQQSTVAMAKQTGWQESI 1317
             |.::::            ||.:||   .:| |.|.::...|||
Human  1740 GFRVLND------------FLAHHV---HIPEVYLIVSTFFLQT--------------------- 1768

  Fly  1318 ARLLIRKPIT---SSPPDEEKRRSFGINLDVLLEDNSNFLAQADLITFSEQEIGLAQLQQQQQEE 1379
                   |:|   ..|.|         :||.:|:    :|                 ||:..|||
Human  1769 -------PLTELMDGPKD---------SLDAMLQ----WL-----------------LQRHHQEE 1796

  Fly  1380 LSDSGLILNEIQASVTEAATVIESEIK-----ELAESVSGAVVENANSLFSVIRQTTHDLQDTFE 1439
            :..:||        .||.|.::...:|     .||.|..||..:...:  ||::         |.
Human  1797 VLQAGL--------CTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPA--SVLQ---------FL 1842

  Fly  1440 SLTQGSSTDTADGSQTPSIQREESLSSDTSSQSPHGPPK--KSDSLESTSAFDFVADGDVDTE-- 1500
            ||...:.      .|.|:.:..|.|.:...:..|.|..|  .::|..:||:.:..|:||...|
Human  1843 SLVHRTY------PQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEGL 1901

  Fly  1501 -------------EQLVYLVSNTL------------FNIFWRGIPNDHPQCWQERGQVLGCINLL 1540
                         .:...|:...|            ..:.....| ||....|:|.
Human  1902 QAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASP-DHATSQQKRD--------- 1956

  Fly  1541 ALNNELITSHLSL----------RLR-------ILEMAVQASLFDLSEHGSQTLVNQ-------E 1581
             ..:|::.|.:.|          ..|       ..|.|...||.::|.. :|.||.:       .
Human  1957 -FQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCF-TQKLVEKLYSGMFSA 2019

  Fly  1582 NASHILRMVYE--LVVLGSNEDESKKCSTKLLDGVLALLDALMIF-----QQGSSDDWSDMIRLC 1639
            :..|||..:.|  :||:   |..|.:..| :|..:.:.|:.::::     ||..|:        |
Human  2020 DPRHILLFILEHIMVVI---ETASSQRDT-VLSTLYSSLNKVILYCLSKPQQSLSE--------C 2072

  Fly  1640 LGLLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYLLYSINRALDNAIEVGNPEEYSFLM 1704
            ||||...........|..||..             :.:|:||     .|.:.:.:.|...|
Human  2073 LGLLSILGFLQEHWDVVFATYN-------------SNISFLL-----CLMHCLLLLNERSY---- 2115

  Fly  1705 PVMKALLEKCRVAF----------NLDSTLPDLPSTSSGPVFFNDFQ---MYSTSKKWRNFIERM 1756
            |....|..|.|::.          ::.....||||.|       |.|   ..:....|:..:.:.
Human  2116 PEGFGLEPKPRMSTYHQVFLSPNEDVKEKREDLPSLS-------DVQHNIQKTVQTLWQQLVAQR 2173

  Fly  1757 VKPLYDRYQRDIELH-------------LW-EPINRFWAECYEACKAASKQRATNQAENRR--LF 1805
            .:.|.|.::.|:.:.             || |.:.:.| :.|.|.:..|....:|.|.:.:  |:
Human  2174 QQTLEDAFKIDLSVKPGEREVKIEEVTPLWEETMLKAW-QHYLASEKKSLASRSNVAHHSKVTLW 2237

  Fly  1806 QQKIYMPWKV---RQVE-------------EMQRLQAAALQHKTIDSHIRKR----------WKT 1844
            ...:....|:   ||.:             |..|.:...|.......|:::|          |..
Human  2238 SGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWAR 2302

  Fly  1845 AKRFLYGPRGPWYTGEVDEEF--WKLSQHENVARMRLKLEPQLYP------NKHENAANLRD--N 1899
            .:..|:|..|.|..||..:..  |:|...|..||||.::: :|.|      .:|:.:.:..|  :
Human  2303 IQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIK-RLSPLEALSSGRHKESQDKNDHIS 2366

  Fly  1900 ATSAYDTKEISEFDSTIKNA------------VVRDFLADDESSQLEEELRQLIDTQAQQDVALE 1952
            .|:|.:..|:     |::.|            .:..|.|..||...|:.|....:.|......|:
Human  2367 QTNAENQDEL-----TLREAEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLD 2426

  Fly  1953 KLVMSQDCELITLMTKVKGRIEVNQSVFTF----------VDLSPPTEDGSKYDFRFSTNKI--- 2004
            |..::|...|:.    |:|.: |::.|..|          ..|||   .|..|..|...:.|
Human  2427 KEKVTQKFSLVI----VQGHL-VSEGVLLFGHQHFYICENFTLSP---TGDVYCTRHCLSNISDP 2483

  Fly  2005 -------------------------REVHLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTK 2044
                                     ||:...::.|:..|||||..:..|.||.|....|:|.|..
Human  2484 FIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKS 2548

  Fly  2045 IVGLPLPNILYGSGRSPAE----LLRASG----LTQRWINREISNFEYLMYLNTIAGRSYNDLSQ 2101
            ..... |::   .|::.:|    |.|..|    :.|:|..|:||||||||||||.|||:.||..|
Human  2549 FCSFQ-PSL---KGKATSEDTLNLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQ 2609

  Fly  2102 YPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIP-KFHYGTH 2165
            ||||||:||||||:.|:|.:||.|||||||:|....:.:.:...::...|...|.:. :.||.||
Human  2610 YPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTH 2674

  Fly  2166 YSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTWK-LLMDNPNDVKELIPEFFYFP 2229
            ||::..|..||:|:.|||.....||.|.||||||.|||:..||: ...:|.:||:||.|||||.|
Human  2675 YSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP 2739

  Fly  2230 EFLKNMNKFDLGHLQITKEKVDDVILPAWAT-TPEEFIAIHRRALESEYVSQHLHHWIDLIFGYK 2293
            |||.|.|..:.|.:| ....:.||.||.||. .|.:||::||:||||::||.:||||||||||||
Human  2740 EFLTNCNGVEFGCMQ-DGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYK 2803

  Fly  2294 QKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETA 2358
            |:||.|.:|:|:|:...|...:||..||:|:.:..:.|.::||||||.||..:|||.|     ||
Human  2804 QQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPAR-----TA 2863

  Fly  2359 L------KLVRAELRRPDLTQ-FLDKVVQYYCELSTPKDPIVYLSPPRSPPRSF--LQLSPDVLV 2414
            .      |.|...:..|...| |...:........|.||..::.....||..:.  :..:...::
Human  2864 AGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTIL 2928

  Fly  2415 SISKSTILGCNSWLSFDKDQGFLLEIDATTANLKN--RKRIFGPFHSSQQPHSQLFAVSTDGKLL 2477
            ::.::.:|....|     ::.|....|..:..|.:  ..::...|.:.......|.||......:
Human  2929 AVERNKVLLPPLW-----NRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTI 2988

  Fly  2478 YAGG------IWDNSLRVYNLNKGKAVASVTR-----HLDIITCIALDNCGSYLVTGSRDCTCIV 2531
            ...|      :|:.|     :.||:......|     |...:||:|.....|.||:||:|||||:
Human  2989 VTSGTSTVVCVWELS-----MTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCIL 3048

  Fly  2532 WSIQ--TNQQGGGSTNNIPVH-----ALT-----------GQSHLQAITQLNTQNSYSPKPLTVL 2578
            |.:.  |:      ...:|.|     |:|           ..:|| ::..:|.|...|   :|..
Human  3049 WDLDHLTH------VTRLPAHREGISAITISDVSGTIVSCAGAHL-SLWNVNGQPLAS---ITTA 3103

  Fly  2579 YGHDDAISSVAI-----YTELDLVVSGSLDGTVNVYTLQEGQFVRTLKPIGCTESCVQISFVTLS 2638
            :|.:.||:...:     :....::::||.||.|.|:..::.:.....:|.| .|...|    ..|
Human  3104 WGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAG-EEPLAQ----PPS 3163

  Fly  2639 YHGH-----IAFSALDDTSHSVHVYSINGCSLGSKYVSGRVTGLASASDY--LVVADDAGDI 2693
            ..||     :|.|...|.|     .::.|  ..|| .|..||.||.:.::  |:|.|:.|.|
Human  3164 PRGHKWEKNLALSRELDVS-----IALTG--KPSK-TSPAVTALAVSRNHTKLLVGDERGRI 3217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	Laminin_G_3	644..752	CDD:463865	23/131 (18%)
		DUF4704	906..>1162	CDD:464870	49/337 (15%)
		DUF4800	1646..1899	CDD:464996	60/317 (19%)
		PH_BEACH	1952..2046	CDD:275391	30/131 (23%)
		Beach	2072..2351	CDD:460459	146/281 (52%)
		NBCH_WD40	2395..2742	CDD:466575	76/344 (22%)
		WD40 repeat	2465..2503	CDD:293791	8/43 (19%)
		WD40 repeat	2509..2580	CDD:293791	25/88 (28%)
		WD40 repeat	2585..2621	CDD:293791	7/40 (18%)
WDFY4	XP_054222398.1	PH_BEACH	2428..2552	CDD:275391	29/131 (22%)
		Beach	2580..2861	CDD:460459	146/281 (52%)
		WD40	<2942..3140	CDD:475233	48/212 (23%)
		WD40 repeat	2977..3020	CDD:293791	9/47 (19%)
		WD40 repeat	3026..3062	CDD:293791	15/41 (37%)
		WD40 repeat	3067..3101	CDD:293791	7/37 (19%)
		WD40 repeat	3111..3162	CDD:293791	10/55 (18%)