DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and wdfy3

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_005165446.1 Gene:wdfy3 / 568432 ZFINID:ZDB-GENE-070705-153 Length:3525 Species:Danio rerio


Alignment Length:3184 Identity:691/3184 - (21%)
Similarity:1174/3184 - (36%) Gaps:953/3184 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 GRLPDELLPAIGKFIIVARD-----VCETEGKLEEQAIEEVAILVDCLVIVCRHFDNILSIIKY- 120
            |||...:|.||..  |.|.|     :.|.:..|.:.| |.|..|.:   :..::|: :|..:.: 
Zfish   417 GRLARMILEAIAN--IYAADYANYFILEAQHTLSQFA-ERVTKLPE---VQSKYFE-LLEFVVFG 474

  Fly   121 -EYKPNLIAILSRVFKQQMELPQSVPAISHLFSSFSAFLEVMYDPYLTWRSFVRGQSADYSRLSY 184
             .|.|     ...:|           ::|.|..|.:::                |.|...:|...
Zfish   475 LNYVP-----CKELF-----------SVSVLLKSSTSY----------------GCSITATRTLL 507

  Fly   185 KPHSVHVEIVPFIYDCFQEEKLI--------RYAEI-----------GESLLNILGAVICGSQLQ 230
            |....|    |...|.|:|..|:        :||.:           |:|..|:...   ..||.
Zfish   508 KLGRHH----PVFSDVFREVGLLEVLVNLLHKYAALLKDPTQTHSDQGDSKNNVAEE---QKQLA 565

  Fly   231 LKVQKSLNSTSTLTNRNTNA----------------------------LTTSSLAPCSGDGLLDC 267
            ..|.::|  |..|...||||                            :....|:| |||.  |.
Zfish   566 WLVMETL--TVLLQGSNTNAGLFREFGGARCVHNIVKYRQCREHALMIIQQLVLSP-SGDD--DM 625

  Fly   268 DNLRNGMKAICPATVSITMSILR--------QWESANNLRRVALQCYAL-MVIVLQKS--SP--- 318
            ..|...|.:...|.:.:...|||        ...:....|:|....|.. :::.:::|  ||   
Zfish   626 GTLLGLMHSAPTAELQLKTDILRALLAVLRESHRTRTVFRKVGGFVYVTSLLLAMERSLCSPPVI 690

  Fly   319 ------EERQIDLVTLVQLYCD---ALQELLATKHFDSGDANFDITSDADQDVAIDMAALSSTVA 374
                  :.:..:|  |..::|.   |::...|..||...:..::..:|     |:.:....|...
Zfish   691 GWEKVNQNKVFEL--LHTIFCTLTAAMRYEPANSHFFRTEIQYEKLAD-----AVRLLGCFSDAK 748

  Fly   375 AVKFFVTGDAGV-------------SEAVSDSNLLELLTNLPKLI-----------------KPW 409
            .|     |.|.|             .|.:...|:...|.:..||.                 .|.
Zfish   749 KV-----GPATVFPSNAQPFQRLLEDEIIPAENVCPTLKHCSKLFIYMYKMATDSFDSRAEQVPP 808

  Fly   410 HISHSSSLCSTMEALAIL--ARHSPQSASQLRQGERIERLFTSLQEYGSPTVELLDTCFMLGYDE 472
            .::|.:||.|.....||.  :||...|:|....|:                 .|.|....|| :.
Zfish   809 CLTHETSLPSPWGTPAITRKSRHGYSSSSNSASGK-----------------ALTDLKLHLG-NS 855

  Fly   473 SEH----FLLLPEVMLRLLNWVPTL-QEREQLHVTSL------VLKGCTDNYRTKTVAC--GSHI 524
            |:|    .::.|..:|.:|:.:|:: .:.:..|...|      :|:....:.|.:.:.|  |.|.
Zfish   856 SQHSSDPVVIHPGAVLAMLDLLPSVSSDTQPEHALDLQLAVANILQLLVHSERNQQILCEAGLHS 920

  Fly   525 -IKAVCGCLL-------------TAESLAENCVQNLI------------------KLIEE----- 552
             :...|.|.|             ..|.||...::.::                  ||:::     
Zfish   921 RLLQRCSCALGDEDHPLHPPLQRMFERLASQALEPMVLREFLRLGNPLNCGAWDKKLLKQYRVHK 985

  Fly   553 -------------------------------------LSKLSIVPAE--------LKCIFSL--- 569
                                                 :|:..:..||        :||:.|:   
Zfish   986 PSSLSYEAEMRNSMTLSMEGFGPDSVFTINEDNSQYRISRSLVRSAEGSTVPLTRVKCLVSMTTP 1050

  Fly   570 ----LRQGTKFPQFKQLQQTLV---VIALQSLRGSNSCAEFFSIEQPTDGILVPDIRNW-----T 622
                |...:..|.|.:|..:|.   .:.|.||...|:.:...:....:||.:|..:.|.     .
Zfish  1051 HDIRLHGSSVTPAFVELDTSLEGFGCLFLPSLAPHNAPSSNANTSGVSDGAVVSGMGNGERFFPP 1115

  Fly   623 ISG-SYGFIFHILVRFNQLKEQSNSRRMLLTLQTASGSGFE------VFVQPNGNVVVAALTRRE 680
            .|| ||...| .:.||: ...||:..|:|..::.|:.|...      |....:.:::|:  |:.|
Zfish  1116 PSGLSYSTWF-CVERFS-TPPQSHPVRLLTVVRRATSSEQHYVCLAIVLSAKDRSLIVS--TKEE 1176

  Fly   681 YLTSST--------------------ATKTLMDGQWHYLTVAITPPKRPFSYSQINIYVDFVQKL 725
            .|.|..                    ....:.:||||:|.:.::  |.....|...:|:|  .::
Zfish  1177 LLQSYVDDFSEESSFYEILPCCARFRCADLITEGQWHHLLLVMS--KGMLKNSMATLYID--GQM 1237

  Fly   726 SATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLERTLSANV 790
            .:|:|:..|:.              .||..| :.|.|..|:..|    |.|..|:  :|.||   
Zfish  1238 VSTVKLHYVHN--------------SPGGSA-SANPPVVSTVYS----YIGTPPA--QRQLS--- 1278

  Fly   791 SNYFTLPMRTQTAFDPNVKNFPIGMQDTVFGEQTCLNGHLGGVLLADPTTSLKTIFDAGANFSSI 855
                ||..|               :..|.|.|:..            |..|:..|::.|.|:...
Zfish  1279 ----TLVWR---------------LGPTHFLEEVL------------PAASVAAIYELGPNYVGS 1312

  Fly   856 FSQDNDLLELNSRFVFCYAPGAIWHGTCQD------------LIPGGKYPGRINAQHCK---IVK 905
            |..             .|.|       |:|            |:|..|....:.|....   :.|
Zfish  1313 FQA-------------VYLP-------CKDSKTEAVPPCPVGLVPEEKVSFSLFAHSVSALTVAK 1357

  Fly   906 IQETINSIG--------GISA-----ILPMLHRLI--------TLDQTTDISIGSVSEESLSCAP 949
            |::..|.:.        |:|:     .:.::|..:        |:....   ||.:...:....|
Zfish  1358 IRKVYNKLDSKAIAKQLGVSSHESATPVKLVHNAVGHLNGSARTVGAAV---IGYLGVRAFVTKP 1419

  Fly   950 TPSAEEF--------------TDWEMLSSNSYTEWKML-----QHPLASFLCLLRYLTHEHETNQ 995
            ..:..::              :|.|.|    |...|.|     .:||||             ...
Zfish  1420 VATNLQYIGGAAAILGLVAMASDVEGL----YAAVKALVCVVKSNPLAS-------------KEM 1467

  Fly   996 EQLLSSECLAIVGTMLQRCPPSLFDVNALMATHLLMESL-QGHKAEAGGQLLDALYAHIVFDFAI 1059
            |::...:.||:   :|::..| |.:.:.|..|..|:.:: .||:......  ...:..::.||.:
Zfish  1468 ERIKGYQLLAM---LLKKKRP-LLNSHILHLTFSLVGTVDSGHETSIIPN--STAFQDLLCDFEV 1526

  Fly  1060 WSRLQFQITLGHAQYLSAMIKNDRKFFRKRYGVQFVLDVVRQYYSTPD---SISDDDAKTIRATL 1121
            |....:::.|...::...::....:..:.       ..::|::...|.   ::.|........|.
Zfish  1527 WLHAPYELHLSLFEHFIELLTESSEAAKN-------AKLLREFQLIPKLLLTLRDQSLSQPTITA 1584

  Fly  1122 FG-IIKFYLQKDVNIKEVNSMITFLASVRQDVVLVEFLEMMTFYVRGKNCKDQMVLLLHEPQSAN 1185
            .| ::...||...|..::.....|::|.           :.||.|    |:..:::         
Zfish  1585 IGNVLSLLLQGFPNTYDLLRFGQFISST-----------LPTFAV----CEKFVIM--------- 1625

  Fly  1186 LLYNFFVDKSYSNEIQEAAIRFISGLLATSRVHQKYKQVLRLYDQTTEQSMFPGFFSFITPLSLS 1250
                   :.:...:|...|.....|||:::.:..:.    ||.|...:|     .||.....:::
Zfish  1626 -------ENTNEEKIDRGADEEFGGLLSSNLILLRN----RLLDILLKQ-----LFSCKEKGTVN 1674

  Fly  1251 STILFHLVDEMLGLQPDYAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQSTVAMAKQ----T 1311
            :.....|| ..||.  |:. |:|:..|:.|..:...|     |:....:..||.::..|:    .
Zfish  1675 AQACEELV-RTLGF--DWL-LMFMEEHIHSSTVTAAL-----LILVVLLSNQSILSRFKEGLSGG 1730

  Fly  1312 GWQESIARLLIRKPITSSPPDEEKRRSFG-------IN-----------LDVLLEDNSN-----F 1353
            ||.:....:|..|  ..:.......||.|       ||           |..||..::|     |
Zfish  1731 GWLDHTDSVLTNK--IGTVLGFNVGRSAGGRSTLREINRDACHFPGFPVLQTLLPKHTNVPEIYF 1793

  Fly  1354 LAQADLITFSEQEIGLAQLQQQQQEEL-------------SDSGLILNEIQASVTEAATVIESEI 1405
            :..|   .|.:|.|  .:|.:..|...             :.|..::..:....||.|.::.:.:
Zfish  1794 MLMA---LFFQQPI--TELPESLQVHFDLDSIWTFIFGVPASSATVVGSLHNMCTETAFLLLAML 1853

  Fly  1406 KEL------AESVSGAVVENANSLFSVIRQTTHDLQDTFESLTQGSSTDTADGSQTP-SIQREES 1463
            :.:      :|.....:.|...:|....|...|::.|............|...:..| :|:....
Zfish  1854 RSMLNLPWQSEEEGSWLREYPITLMQFFRYLYHNIPDLAPMWHSPDFLCTLAATVFPFNIRPYSE 1918

  Fly  1464 LSSDTSSQSPHGPPKKSDSLESTSAFDFVADGDVDTEEQLVYLVSNTLFNIFWRGIPNDHPQCWQ 1528
            :.||...::       |...|...|  ||.|..::..:.....|.|..:       ..:||    
Zfish  1919 MVSDLDDEA-------SSPTEEFKA--FVTDTGMNRSQSEYCNVGNKTY-------LTNHP---- 1963

  Fly  1529 ERGQVLGCINLLALNNELITSHLSLRLRILEMAVQASLFDLSEHGSQTLVNQENASHILRMVYEL 1593
            .:..|...:.||.::| |..:..|.:..|:::.::||    .|..::| ..:|..|:||..|.|.
Zfish  1964 AKKYVFDFMRLLIMDN-LCMTPASKQTPIIDLLLEAS----PERSTRT-QQKEFQSYILDSVMEQ 2022

  Fly  1594 -----VVLGSNEDESKKCSTKLLDGVLALLDALMIFQQGSSDD-WSDMI---------------- 1636
                 |::|  |:.|...:|.  .....|::.:..|.|...|. |..|.                
Zfish  2023 LLAADVLMG--EEASLPITTG--GSYQVLVNNVFYFTQRVVDKLWQGMFNKESKLVVDFIVQLIT 2083

  Fly  1637 ---RLCLGLLLKCSHHPNPGIVAMATAKLHAILQSRSTEDPAELSYL----LYSINRALDNAIEV 1694
               |...||.|...:|.....:....::.|..:       |.:::.|    :.::||.|  .:..
Zfish  2084 QSKRRSQGLSLDSVYHCLNRTILYQLSRPHKTV-------PQQVTLLDSLRVLTVNRNL--VLGP 2139

  Fly  1695 GNPEEYSFLMPVMKALLEKCRVAFNLDSTLPD---------------LPS-TSSGPVFFNDFQ-- 1741
            ||.:: .|:     |.|..|.:..:..|::..               :|| ..|..|...|..  
Zfish  2140 GNHDQ-EFV-----ACLAHCLINLHTGSSVEGFGLEAEARMTTWHVAVPSENESDSVQSQDVSEG 2198

  Fly  1742 ----MYSTSKKW-------RNFIERMVK---PLYDRYQRDI---ELHLWEPINRFW-------AE 1782
                :.:.::.|       |..:|.:.|   |:.||...||   ...|.||..:.|       .:
Zfish  2199 RQLLLKAVNRVWTELMHSKRQMLEDIFKVSLPVNDRGHVDIGTARPALEEPAAKSWQNHLVHEKK 2263

  Fly  1783 C---------------------YEACKAASKQRATNQA--ENRRLFQQKIYMPWK------VR-- 1816
            |                     :...|....:|:..::  ....|..|:.:. |.      ||  
Zfish  2264 CISRGETVAPANQSKLSRVSSGFGLSKLTGSRRSKKESGMNKNNLSAQETFQ-WMFTHIAVVRDL 2327

  Fly  1817 ---QVEEMQRLQAAALQHKTIDSHIRKRWKTAKRFLYGPRGPW---YTGEVDEEFWKLSQHENVA 1875
               |.:|.|..|..||:      ::...|...:..|...||.|   ....:|:  ::|...|...
Zfish  2328 VAMQYKEHQERQQNALK------YVMDEWAGIEYELLRERGLWGPPIGSHLDK--FQLDMTEGPC 2384

  Fly  1876 RMRLKL--EPQLY------PNKHENAAN---LRDNATSAYDTKE--------------------- 1908
            |||.|:  ....|      |:...||:.   .|.....:||:||                     
Zfish  2385 RMRKKMVRNDMFYIHYPYVPDPEPNASTQKPARYRRAISYDSKEYYMRLLSGNPGMYQHSIEQNT 2449

  Fly  1909 ---------------ISEFDSTIKNAVVRD-FLADDESSQLEEELRQLIDTQAQQD-------VA 1950
                           |:.....:|..:.|. ..||....:.:::|::|:::.|..:       ..
Zfish  2450 EGETTQQEPEHGEDTIARVKGLVKAPLKRSRSTADGADEESQDQLQELLESGAMDEEQKTDNTTL 2514

  Fly  1951 LEKLVMSQDCELITLMTKVKGRIEVNQSVFTF---------------------VDLSPPT----- 1989
            |..|...:..:.:....:|:| ::.::.:..|                     ::..||.     
Zfish  2515 LRLLEEGEKIQHMYRCARVQG-LDTSEGLLLFGKEHFYVIDGFTMTVTREIRDIETLPPNMHEPI 2578

  Fly  1990 ----EDGSKYDFR-----FSTNKIREVHLRKYNLRRSALEIFLVDQTSYFLNFTTKTRNKVFTKI 2045
                ...||...:     |:...|||||.|:|.|:..|.|:|..|..:|.|.|....||||:.:.
Zfish  2579 IPRGARQSKSQLKRTCSIFAYEDIREVHKRRYLLQPMAAEVFSGDGRNYLLAFQKGVRNKVYQRF 2643

  Fly  2046 VGL---------------PLPNILYGSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRS 2095
            :.:               |..::..|||.. :.|:....:||||...|||||:|||:|||:||||
Zfish  2644 LAVVPSLADSSESVSGQRPNTSVEQGSGLL-STLVGEKSVTQRWERGEISNFQYLMHLNTLAGRS 2707

  Fly  2096 YNDLSQYPVFPWILADYTSDVLDLTDPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKF 2160
            ||||.|||||||||||:.|:.|||.:||:||:||||:|........:.:.::..:|||:|..|.:
Zfish  2708 YNDLMQYPVFPWILADFDSEELDLNNPKTFRNLSKPMGAQTDDRLIQYKKRFKDWEDPNGETPAY 2772

  Fly  2161 HYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSGRFDVADRQFHSIPQTW-KLLMDNPNDVKELIPE 2224
            |||||||::..|..||:|:||||.:.:.||.|.||:|||.|||:.:.| .....|..||||||||
Zfish  2773 HYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADRMFHSVREAWLSASKHNMADVKELIPE 2837

  Fly  2225 FFYFPEFLKNMNKFDLGHLQITKEKVDDVILPAWAT-TPEEFIAIHRRALESEYVSQHLHHWIDL 2288
            |||.||||.|.|.||||..| ...|:.|||||.||. .|.|||.:||.|||.:|||.|||.||||
Zfish  2838 FFYLPEFLLNSNNFDLGSKQ-NGTKLGDVILPPWAKGDPREFIRVHREALECDYVSAHLHEWIDL 2901

  Fly  2289 IFGYKQKGPKAAEALNVFYYCSYEGAVDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLT 2353
            ||||||:||.|.||:|||::..|||.||:..|.:|::..|..|.||||||:|.||.::|||.   
Zfish  2902 IFGYKQQGPPAVEAVNVFHHLFYEGQVDIYNINDPLKETATIGFINNFGQIPKQLFKKPHPP--- 2963

  Fly  2354 QDETALKLVRAELRRP------DLTQFLDKVVQYYCELSTPKDPIVYLSPPR--SPPRSFLQLSP 2410
                  |.||::....      .|...|||:..::.:...|.     |:|.:  ..|...:..:.
Zfish  2964 ------KRVRSKSNGEAPGGPVTLNSTLDKIFFHHLDNLRPS-----LTPVKELKEPVGQIVCTD 3017

  Fly  2411 DVLVSISKSTILGCNSWLSFDKDQGF---LLEIDATTANLKNRKRIFGPFHSSQQPHSQLFAVST 2472
            ..::::.::.:|...:|     ::.|   ..::....:|.::.|.:. .:....:....|.|:..
Zfish  3018 KGILAVEQNKVLVPPAW-----NKTFAWGYADLSCRLSNYESDKAVV-VYECLSEWGQILCAICP 3076

  Fly  2473 DGKLLYAGG------IWDNSLRVYNLNKGKAVA---SVTRHLDIITCIALDNCGSYLVTGSRDCT 2528
            :.||:..||      :|:..   .:..|.|::.   ::..|.|.:||:...:....:|:||||.|
Zfish  3077 NPKLVITGGFSTAICVWETG---SSKEKAKSLTLKQALLGHTDAVTCLTASSAYHIVVSGSRDRT 3138

  Fly  2529 CIVW-----SIQTNQQGGGSTNNIPVHA-----LTGQ--------SHLQAI--TQLNTQNSYSPK 2573
            ||:|     |..|..:|    :..||.|     |||.        .|:.:|  :.:.:.|:::.:
Zfish  3139 CIIWDLNKLSFVTQLRG----HRAPVSALCINELTGDIVSCAGTYIHVWSINGSPVASANTFTGR 3199

  Fly  2574 PLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQFVRT-----LKPIGCTESCVQI 2632
            ...:|.   ..:|.:..:...:::|:|..||.|..:.::..|...|     ::|....:.|.:|
Zfish  3200 SQQILC---CCVSEMNEWDTQNVIVTGHSDGVVRFWRIEFLQVPETPAPEPIEPPDVPDCCGEI 3260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 24/134 (18%)
DUF4704 906..1162 CDD:292415 44/300 (15%)
DUF4800 1650..1899 CDD:292675 62/342 (18%)
PH_BEACH 1952..2046 CDD:275391 28/128 (22%)
Beach 2072..2351 CDD:280327 163/280 (58%)
WD40 <2428..2734 CDD:225201 49/242 (20%)
WD40 repeat 2465..2503 CDD:293791 9/46 (20%)
WD40 2468..2687 CDD:295369 45/199 (23%)
WD40 repeat 2509..2580 CDD:293791 24/90 (27%)
WD40 repeat 2585..2621 CDD:293791 8/40 (20%)
wdfy3XP_005165446.1 DUF4704 1401..>1573 CDD:292415 31/204 (15%)
PH_BEACH 2522..2645 CDD:275391 27/123 (22%)
Beach 2684..2964 CDD:280327 163/289 (56%)
WD40 repeat 3033..3060 CDD:293791 4/32 (13%)
WD40 3043..>3240 CDD:225201 44/207 (21%)
WD40 repeat 3071..3113 CDD:293791 9/44 (20%)
WD40 3072..>3234 CDD:295369 40/171 (23%)
WD40 repeat 3118..3154 CDD:293791 13/35 (37%)
WD40 repeat 3161..3196 CDD:293791 7/34 (21%)
FYVE_WDFY3 3449..3513 CDD:277259
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D101142at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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