DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43367 and nbeab

DIOPT Version :9

Sequence 1:NP_001189048.2 Gene:CG43367 / 38505 FlyBaseID:FBgn0263110 Length:2754 Species:Drosophila melanogaster
Sequence 2:XP_009290096.1 Gene:nbeab / 565885 ZFINID:ZDB-GENE-120329-2 Length:2891 Species:Danio rerio


Alignment Length:3021 Identity:642/3021 - (21%)
Similarity:1052/3021 - (34%) Gaps:1082/3021 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 MLRLLNWVPTLQEREQLHVTSLVLKGCTDNYRTKTVACGSHIIKAVCGCLLTAESLAENCVQNLI 547
            ||.||.......:.|...:.:.:|:....|.:|      |..:..:...|:...|:.:.....|:
Zfish   113 MLELLEHCEVTCQAEIWSMFTAILRKSVRNLQT------SSEVGLIQRLLIKMSSVDDMIADLLV 171

  Fly   548 KLIEELSKLSIVPAELKCIFSLLR-QGTKFPQFKQLQQTLVVIALQSLR-GSNSCAEFFSIE-QP 609
            .::..|:..||...|||.:||:|| :|..:|  :...:.|.|::..:.| |.::   ||:.. :.
Zfish   172 DMLGVLASYSITVKELKLLFSMLRGEGGLWP--RHAVKLLSVLSQMAQRHGPDT---FFNFPGRS 231

  Fly   610 TDGILVPDIRNWTISGSYGFIFHILVRFNQLK--EQSNSRRMLLTLQTASGSGFEV-FVQPNGNV 671
            ...|.:|.|..|....  ||..:...|.:.|.  .....:..|...:|:.|.|:.. ||   ||.
Zfish   232 AAAIALPPIAKWPYQN--GFTLNTWFRMDPLNNINVDKDKPYLYCFRTSKGIGYSAHFV---GNC 291

  Fly   672 VVAALTRREYLTSSTATKTLMDGQWHYLTVAITPPK------------------RPFSYSQINIY 718
            ::.           |:.|:...|..|.:.....|.|                  |.:...|:..|
Zfish   292 LIV-----------TSLKSKGKGFQHCVKYDFQPRKWYMVSIVHIYNRWRNSEIRCYVNGQLVSY 345

  Fly   719 VDFVQKLSATLKVQAVNEPFTVCSIGAVVAPPQPGEVAKTGNMPRSSSQESGSSGYKGMLPSLLE 783
            .|....::       .|:.:..|.:|                   ||.....:..:.|.|.::..
Zfish   346 GDMAWHVN-------TNDSYDKCFLG-------------------SSETADANRVFCGQLGAIYV 384

  Fly   784 RTLSANVSNYFTLPMRTQTAFDPNVKN-FPIGMQDTV----FGEQTCLNGHLGGVLLADPTTSLK 843
            .:.:.|.:..|.:..     ..|..|: |....:..:    ..:|...:|.|        ..|:.
Zfish   385 FSEALNPAQIFAIHQ-----LGPGYKSTFKFKSESDIHLADHHKQVLYDGKL--------ANSIS 436

  Fly   844 TIFDAGANFSSIFSQDNDLLELNSR---FVFCYAPGAIWHGTCQDLIPGGKYPGRINAQHCKIVK 905
            ..::|.|..:.:      .||.:.|   .:|.::|.|:   ..||:        :....|    .
Zfish   437 FTYNAKATDAQL------CLESSPRENPSIFVHSPHAL---MLQDV--------KAIVTH----S 480

  Fly   906 IQETINSIGGISAILPMLHRLITLDQTTDISIGSVSEESLSCAPTPSAEEFTDWEMLSSNSYTEW 970
            |...|:|||||..:.|:                                    :..|..:.:.|.
Zfish   481 IHSAIHSIGGIQVLFPL------------------------------------FAQLDFHQHNES 509

  Fly   971 KMLQHPLASFLCLLRYLTHEHETNQEQLLSSECLAIVGTMLQRCPPSLFDVNALMATHLL--MES 1033
            ::.....::.|..|..|.......|||:|..:...::|.:|::  .|...|...:....|  .:.
Zfish   510 QVETTVCSTLLAFLMELLKSSVAMQEQMLGGKGFLVIGYLLEK--SSRVHVTRAVLDQFLSFAKY 572

  Fly  1034 LQG--HKAEAGGQLLDALYAHIVFDFAIWSRLQFQITLGHAQYLSAMIKNDRKFFR--KRYG-VQ 1093
            |.|  |    |..||..|..||:|:.|||..:..::.|....|||:........:.  :|.| |.
Zfish   573 LDGLTH----GAPLLKQLCDHILFNAAIWIHIPAKVQLSLYTYLSSEFIGTTTIYSTIRRVGTVL 633

  Fly  1094 FVLDVVRQYY----------STPDSI-----SDDDAKTIRATLFGIIKFYLQKDVNIK--EVNSM 1141
            .::.:::.||          .||..:     |..:..::||.:...:|..:.||..:|  |:.|:
Zfish   634 QIMHILKYYYWAVNPNNTSGITPKGLDGPRPSQKEISSLRAFMLLFLKQLILKDRGVKEDELQSI 698

  Fly  1142 ITFLASVRQD-------------------------------------------VVLVEFLEMMTF 1163
            :.:|.::.:|                                           .:.|:.|:::.:
Zfish   699 LNYLLTMHEDENLHDVLQLLVALMSEHPASMIPAFDQRNGIRVVYKLLASKSESIRVQALKVLAY 763

  Fly  1164 YVR--GKNCKDQMV------------LLLH------------------------------EPQS- 1183
            :::  |...|.:::            |:||                              ||.| 
Zfish   764 FLKHLGHKRKVEIMHTNSLFTLLGERLMLHSNTVSITTYNTLYEILTEQVCTQVVHKPHVEPDST 828

  Fly  1184 ------------ANLLYN-------------FFVD--KSYSN----------------------- 1198
                        |.||.|             |..|  |.:||                       
Zfish   829 VKIQNPMILKVVATLLKNSTPSADLMEVRRLFLSDMIKLFSNSRENRRCLLQCSVWQDWMFSLGY 893

  Fly  1199 ---------EIQEAAIRFISGLL------------------------ATSRVHQKYKQVLRLYDQ 1230
                     :|.|........||                        .|...|::|  :.::|::
Zfish   894 INPKNSEEQKITEMVYNIFRILLYHAIKHEWGGWRVWVDTLSIAHSKVTYEAHKEY--LAKMYEE 956

  Fly  1231 TTEQSM------FPGFFSFITPLSLSSTIL----------------------------FHLVDEM 1261
            ...|..      ..|..|.|:.||..::.:                            .:::.|.
Zfish   957 YQRQEEENIKKGKKGLVSTISGLSAQASSIKGTLELDADSQTQTPESEADEPETTDSGRNILSET 1021

  Fly  1262 LGLQPD--YAGLIFLVYHVSSCDLPVKLEIAKRLLQTTFVKQQ--------------------ST 1304
            ..|..|  .:|:     ||...||.|.::..|  ::.|.||..                    ..
Zfish  1022 KSLDEDNPASGV-----HVEVHDLLVDIKAEK--VEATEVKMDDLDLLPVTENGGLVEVDSLLDN 1079

  Fly  1305 VAMAKQTGWQESIARLLIRK---------PITSSPPDEEKRRSFGINLDVLLEDNSNFL------ 1354
            |..|.......|:..:|:.|         |:.:...:::           .:..|:.||      
Zfish  1080 VYSAAVEKLNSSVNNVLVPKASLENKNSGPLITLADEKD-----------AISSNNTFLFGTLAS 1133

  Fly  1355 --------------------AQADLITFSEQEIGLAQLQQQQQEELSD----------------S 1383
                                .:..:.|.|..::||..|..:..:|||.                |
Zfish  1134 GSGENLLPEIGPSEPLPLSGVEPQVHTSSSADLGLLALMSKSSKELSANTVALEDDSFKMQPALS 1198

  Fly  1384 GLILNE-------------IQASVTEAATVI---------------ESEIKEL------------ 1408
            |..::|             :...:.:.|:.:               |.|||::            
Zfish  1199 GFSISEGESLTKCPGQVETVAVDLEQGASGVKDVSTSDTEKSDDGKEKEIKKIQTTATTQSLHGR 1263

  Fly  1409 ----------------------------------------------------------------- 1408
                                                                             
Zfish  1264 SGSHLDRDLRVDLGFRAMPMTEEQRRQFSPGPRTTMFRIPEFKWSPMHQRLLTDLLFALESDVHI 1328

  Fly  1409 -----AESVSGAVVENANSLFSVIRQTTHDLQDTFESL--------------------------- 1441
                 .:|:...|..|.|.:|  :..|.|.:....:::                           
Zfish  1329 WRSHSTKSIMDFVNSNENIIF--VHNTIHLISQMVDNIIIACGGILPLLSAATSPSNSKSEMEGL 1391

  Fly  1442 --TQGSSTDT-----------------ADGSQTPSIQREESLSS--------------------- 1466
              |||.|::|                 |.......|:.|:::||                     
Zfish  1392 EVTQGMSSETAVIFLTRLMAIVDVLVFASSLNFSEIEAEKNMSSGGLMRQCLRLVCCVAVRNCLE 1456

  Fly  1467 ------DTSSQSPHGPPKKSDSLES------TSAFDFVAD------------------------G 1495
                  |.|.:|.....|..:.|:|      |:..:|.::                        .
Zfish  1457 CRQRQRDRSLKSSLSCSKSQEGLQSVSTASKTTIENFPSNVSPIKDPDRLLQDVDINRLRAAVFR 1521

  Fly  1496 DVDTEEQ-------LVYLVS-----------------NTLFNIFWRGI--------PNDHPQCWQ 1528
            |||..:|       :||.:|                 ....|...|||        ..|||....
Zfish  1522 DVDDSKQAQFLALAVVYFISVLMVSKYRDILEPQRETGRFINQSGRGIRQEINSPTSTDHPSLLT 1586

  Fly  1529 E-RGQVLGCINL----------LALNNELITS----------------------HLSLRLRILEM 1560
            : |.:.||.:..          ..|.::.::|                      .||...|..|.
Zfish  1587 DSRKEALGVLESRQESSLPHSDSGLGDDQVSSVMNGADLDLAMGGPNGMSGLFCTLSSVARSQES 1651

  Fly  1561 AVQ-ASLFDLSEHGSQTLVNQENAS-HILRMVYELVVLGSNEDESKKCSTKLLDGVLAL------ 1617
            .:: :|:..|....|.:.:||.|.. ::..::..||.......||         |..||      
Zfish  1652 LIEPSSVEHLKTASSISSINQANKGINVKEILKSLVAAPVETTES---------GTEALPYPEQQ 1707

  Fly  1618 -----LDALMIFQQGSSDDWSDMIRLCLGLLLKCSHHPN---------------------PGIVA 1656
                 ..|:|..|..|.|         ..::::....|:                     |.|.|
Zfish  1708 AMKREAQAMMPMQFHSFD---------RSVVVQAKKPPSGLTVNTVGTSGSSSALTSGSTPNIFA 1763

  Fly  1657 MATAKLHAILQSRSTEDPAELSYLLYSINRALDNAIEVGNPEEYSFLMPVMKALLEKCRVAFNLD 1721
            .|:....:::.:....|.:..|...: :|.|...     |......:.|:.:..:|...:...|:
Zfish  1764 AASITPKSMINTTGATDTSSSSSASF-VNGATSK-----NLPAVQTVAPMPEDTMENMSITTKLE 1822

  Fly  1722 STL---------------PDLPST------------------SSGPVFFNDFQMYSTSKKWRNFI 1753
            ..|               |.|..|                  ||..|.  :..|...|::|:|.|
Zfish  1823 RALEKVAPLLREIFVDFAPFLSRTLLGSHGQELLIEGLVCMKSSTSVV--ELVMLLCSQEWQNSI 1885

  Fly  1754 ERMVKPLYDRYQRDIELHLWEPINRFWAECYEACKAASKQ---RATNQAE---NRRLFQQKIYMP 1812
                       |::..|...|.||.....|:     |.|.   |..|:||   ||:         
Zfish  1886 -----------QKNAGLAFIELINEGRLLCH-----AMKDHIVRVANEAEFILNRQ--------- 1925

  Fly  1813 WKVRQVEEMQRLQAAALQH-------KTIDSHIRKRWK------------------TAKRFLYGP 1852
             :...|.:....:::..|:       :|:..|:....|                  |.|...:|.
Zfish  1926 -RAEDVHKHAEFESSCAQYAADRKEEETMCDHLISAAKHRDHVTANQLKQKILNILTNKHGAWGA 1989

  Fly  1853 RG-------PWYTGEVDEEFWKLSQHENVARMRLKLEPQLYPNKH--------------ENAA-- 1894
            ..       |:.:.:...:||:|...|:..|.|.:.....:.:.|              |:.|  
Zfish  1990 AAQRSSCLFPFSSQQQQHDFWRLDYWEDDLRRRRRFIRNPFGSTHLDITCKSLEDYGPEEDEALR 2054

  Fly  1895 ---NLRDNATSAYDTKE--ISEFDSTIKNAVVRDFLADDESSQLEEELRQLIDTQAQQDVALEKL 1954
               ..|..|:.:.:|:.  :.|.|             ||..|.|:|:         :.|.....:
Zfish  2055 GRKGFRGQASVSQNTETELMLEGD-------------DDAVSLLQEK---------EVDNLAGPV 2097

  Fly  1955 VMSQDCELITLMTKVKGRIEVNQSVFTF-VDLSPPT-----------EDGSKYDFRFSTNKIREV 2007
            |:|...:||..:|..:|.:.:..:...| ||...|.           .:|....:.||  :||.|
Zfish  2098 VLSTPAQLIAPVTVARGTLSITTTEIYFEVDEDDPAFRRIDAKVLVYSEGLHGKWMFS--EIRAV 2160

  Fly  2008 HLRKYNLRRSALEIFLVDQTSYFLNFTTK-TRNKVFTKIVGLP---------LPNILYGSGRSPA 2062
            ..|::.|:.:|||||:.::||...||..: |..||   :..||         ||.....|..||.
Zfish  2161 FTRRFLLQNTALEIFMANRTSVMFNFPDQPTVKKV---VYSLPCVGVGTSYGLPQARRISLASPR 2222

  Fly  2063 ELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLTDPKSFRD 2127
            :|.::|.:||||..||||||||||:|||||||:||||:|||||||:|.::.|:.||||.|.:|||
Zfish  2223 QLFKSSNMTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWVLTNFESEELDLTVPSNFRD 2287

  Fly  2128 LSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSLHIDLQSG 2192
            ||||||.:|||.......:|:|:::.:   |..||.||||.:...||:|:|:||||:..::....
Zfish  2288 LSKPIGALNPKRAVFYADRYESWDEET---PPCHYTTHYSTANSTLHWLVRIEPFTTFFLNANGN 2349

  Fly  2193 RFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFFYFPEFLKNMNKFDLGHLQITKEKVD-----D 2252
            :||..:|.|.||.::|:....:..|||||||||:|.||...|.|.:.||      ::.|     |
Zfish  2350 KFDHPNRTFSSIARSWRHCQRDTADVKELIPEFYYLPEMFVNSNGYCLG------DRDDGVPVCD 2408

  Fly  2253 VILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGAVDL 2317
            |.|||||..||:|:.|:|.|||||:||..||.||||||||||:||:||.|||||::.:|||:|:|
Zfish  2409 VELPAWAKKPEDFVRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAARALNVFHHLTYEGSVNL 2473

  Fly  2318 DKI-TNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVVQY 2381
            |.: ::|..|||.|..|.:.||.|||||.||||.|    .:|:.|  ..|.:..| .|.|::.| 
Zfish  2474 DSLASDPPLREATEAQIQSVGQSPSQLLIEPHPPR----SSAMHL--CFLPQSPL-MFKDQMQQ- 2530

  Fly  2382 YCELSTPKDPIVYLSPPRSPP------RSFLQLSPDVLVSISKSTILGCNSW-----------LS 2429
                    |.|:.|..|.:.|      .:...|:...:|:::.|.:...|.|           .|
Zfish  2531 --------DVIMVLKFPSNSPVTHVAANTLPHLTLPAVVTVTCSRLFAVNRWHNTVGLRGAPGYS 2587

  Fly  2430 FDKDQGFLLEIDATTANLK--NRKRIFGPFHSSQQPHSQLFAVSTDGKLLYAGGIWDNSLRVYNL 2492
            .::.....:|:|:..||..  |:::|......|.|.::|.|.|:.|.:.:...|.||.|.|||:.
Zfish  2588 LEQAHHLPIEMDSLIANNSGTNKRQITDLVDQSIQINTQCFVVTADNRYILVCGFWDKSFRVYSS 2652

  Fly  2493 NKGKAVASVTRHLDIITCIALD------NCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHA 2551
            :.||....|..|.|::||:|..      :|  |:|:||||.|.::|                  .
Zfish  2653 DTGKLTQIVFGHWDVVTCLARSESYIGGDC--YIVSGSRDATLLLW------------------Y 2697

  Fly  2552 LTGQSHLQAITQLNTQNSYSPKPLTVLYGHDDAISSVAIYTELDLVVSGSLDGTVNVYTLQEGQF 2616
            .:|:.|   |...|..||..|.|..||.|||..:..|::..||.:::||:.:|...|:|: .|..
Zfish  2698 WSGRHH---IIGDNPNNSDYPAPRAVLTGHDFEVVCVSVCAELGIIISGAKEGPCLVHTI-TGDL 2758

  Fly  2617 VRTLKPIGCTESCVQISFVTLSYHGH--IAFSALDDTSHSVHVYSINGCSLGSKYV--SGRVTGL 2677
            :|.|:.   .:|||....:.:|..||  |.|......|     :||||..|....:  |.|...|
Zfish  2759 LRALEG---PDSCVLPRLICVSSEGHCIIYFDRGQFCS-----FSINGKLLAQMEINDSTRAIVL 2815

  Fly  2678 ASASDYLVVADDAGDITMSRLHGLKPVFDIP 2708
            :|....||...|.|.:.:.:....|.::..|
Zfish  2816 SSDGQNLVTGGDNGVVEVWQACDFKQLYVYP 2846

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43367NP_001189048.2 LamG 643..752 CDD:304605 21/127 (17%)
DUF4704 906..1162 CDD:292415 59/322 (18%)
DUF4800 1650..1899 CDD:292675 58/359 (16%)
PH_BEACH 1952..2046 CDD:275391 30/106 (28%)
Beach 2072..2351 CDD:280327 154/284 (54%)
WD40 <2428..2734 CDD:225201 85/293 (29%)
WD40 repeat 2465..2503 CDD:293791 14/37 (38%)
WD40 2468..2687 CDD:295369 71/228 (31%)
WD40 repeat 2509..2580 CDD:293791 22/76 (29%)
WD40 repeat 2585..2621 CDD:293791 10/35 (29%)
nbeabXP_009290096.1 LamG 247..394 CDD:304605 30/188 (16%)
DUF4704 464..735 CDD:292415 62/327 (19%)
DUF1088 1899..2077 CDD:284000 30/192 (16%)
PH_BEACH 2103..2200 CDD:291510 28/101 (28%)
Beach 2232..2508 CDD:280327 154/284 (54%)
WD40 <2580..2879 CDD:225201 85/299 (28%)
WD40 repeat 2626..2663 CDD:293791 14/36 (39%)
WD40 2627..2879 CDD:295369 75/252 (30%)
WD40 repeat 2669..2723 CDD:293791 22/76 (29%)
WD40 repeat 2728..2763 CDD:293791 10/35 (29%)
WD40 repeat 2767..2797 CDD:293791 10/34 (29%)
WD40 repeat 2806..2846 CDD:293791 9/39 (23%)
WD40 repeat 2852..2878 CDD:293791
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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