DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43367 and nsmaf

DIOPT Version :9

Sequence 1:	NP_001189048.2	Gene:	CG43367 / 38505	FlyBaseID:	FBgn0263110	Length:	2754	Species:	Drosophila melanogaster
Sequence 2:	XP_003199050.1	Gene:	nsmaf / 550506	ZFINID:	ZDB-GENE-050417-342	Length:	911	Species:	Danio rerio

Alignment Length:	873	Identity:	256/873 - (29%)
Similarity:	390/873 - (44%)	Gaps:	204/873 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1884 QLYPNKHENAANLRDNATSAYD--TKEIS-EFDSTIKNA-VVRDFLADDESSQLEEE-------- 1936
            |:|..|.||..     |...||  .|:|: :..|.||.. ||:..|....:|:|:::
Zfish   103 QIYQIKEENVV-----APYKYDRGEKKITFQLGSPIKTEDVVQILLQLHRASRLDKQSDQTAMIA 162

  Fly  1937 -------LRQLIDTQAQQDVALEKLVMSQDCELITLMTKVKGRIEVNQSVFTFVDLSPPTEDGSK 1994
                   .|...|..:.|:|. |...|..:.|:::.:....|.:.:......|..|:...:.
Zfish   163 AILQSRLARTRFDKNSFQNVT-ELPHMECEAEMVSPLVTNAGHVCITDCNLYFQPLNSYPDS--- 223

  Fly  1995 YDFRFSTNKIREVHLRKYNLRRSALEIFLVDQ---TSYFLNF-TTKTRNKVFTKIVGLPLPNILY 2055
             ..:...:.:|.::.|::.||...||:|..:.   :..:|.| .||.|::::..|... |.|.:
Zfish   224 -VVQIGLHSVRRIYKRRHGLRPLGLEVFCTENDLCSDIYLKFYKTKDRDELYYYIATF-LENHV- 285

  Fly  2056 GSGRSPAELLRASGLTQRWINREISNFEYLMYLNTIAGRSYNDLSQYPVFPWILADYTSDVLDLT 2120
                  ||....|.:.| |....|||::||::||.:|.||.|||||||||||:::||:|..|||.
Zfish   286 ------AEHTAESYMLQ-WQRGHISNYQYLLHLNNLADRSVNDLSQYPVFPWVISDYSSTQLDLL 343

  Fly  2121 DPKSFRDLSKPIGCINPKNEAEVRGKYDSFEDPSGAIPKFHYGTHYSNSAGVLHYLLRVEPFTSL 2185
            :|.||||||||||.:|.:....:..:|....:     |:|.||:|||:...||.||:||.|...|
Zfish   344 NPASFRDLSKPIGALNKERLERLLERYRDMPE-----PRFMYGSHYSSPGYVLFYLVRVAPEHML 403

  Fly  2186 HIDLQSGRFDVADRQFHSIPQTWKLLMDNPNDVKELIPEFF-YFPEFLKNMNKFDLGHLQITKEK 2249
              .||:||||.|||.|:||.:|||..::...|.|||||||: ....||:|:...|||..| ...:
Zfish   404 --CLQNGRFDHADRMFNSIGETWKNCLEGGTDFKELIPEFYGSDSSFLRNLLGLDLGRRQ-GGGR 465

  Fly  2250 VDDVILPAWATTPEEFIAIHRRALESEYVSQHLHHWIDLIFGYKQKGPKAAEALNVFYYCSYEGA 2314
            |::|.||.||:.|::|:.....||||:|||:|||.||||||||||:|.:|..:.|||:..:|||.
Zfish   466 VENVELPPWASDPDDFLQKMCLALESQYVSEHLHEWIDLIFGYKQRGSEAVASHNVFHPLTYEGG 530

  Fly  2315 VDLDKITNPVEREAVEGMINNFGQVPSQLLREPHPRRLTQDETALKLVRAELRRPDLTQFLDKVV 2379
            ||.|.|.:|.::.|:...|..|||.|.||...|||:|:|.
Zfish   531 VDCDSIEDPDQKIAMLTQILEFGQTPRQLFVTPHPQRITP------------------------- 570

  Fly  2380 QYYCELSTPKDPIVYLSPPRSPPRSFLQLSPD------------VLVS---ISKSTILGCNSWLS 2429
            ::|...:||......|||......||..|:.:            ||.|   |.|..:.|....||
Zfish   571 RFYNLSTTPSLSSSELSPVSPCMESFEDLTEESRKMAWSNMNKLVLQSCHKIHKEAVTGVAVTLS 635

  Fly  2430 FDKDQGFLLEIDATTANLKNRKRIFGPFHSSQQPHS-QLFAVST-----DGKLLYAGGIWDNSLR 2488
              .|..|....|:|.       ::|...:..|:..| ...|:|:     |.|::.... |||::.
Zfish   636 --GDSIFTTSQDSTL-------KMFSKENGLQRSVSFSNMALSSCLMLPDDKIVVCSS-WDNNVY 690

  Fly  2489 VYNLNKGKAVASVTRHLDIIT----------------------CIALD----------------- 2514
            .|::..|:...::..|.|.::                      |:|.|
Zfish   691 FYSIAYGRRQDTLMGHDDAVSDICWRDDKLYTASWDSTVKVWECVAADISSNKRTQFDPLAEFEH 755

  Fly  2515 ----------NCGSYLVTGSRDCTCIVWSIQTNQQGGGSTNNIPVHALT---GQSHLQAITQLNT 2566
                      ..|:.|.||:::.|..||.:         .:.:||:.||   |:.|
Zfish   756 EAGVNTLDLSPAGTLLATGTKEGTLTVWDL---------ASPLPVNQLTCHSGKIH--------- 802

  Fly  2567 QNSYSPKPLTVL-YGHDDAISSVAIYTEL------------------DLVVSGSLDGTVNVYTLQ 2612
            |.::||....:| .|.|..:....:.|.:                  :.|:||.:.|.::|:.|.
Zfish   803 QVAFSPDSRHILSVGEDSCLMVTDVQTGMLIATIPAEQEQRCFCWDGNTVLSGGISGDLSVWNLL 867

  Fly  2613 EGQFVRTLK-----PIGC---TESCVQI 2632
            ..:.|..:.     .:.|   .|.|..|
Zfish   868 NSKVVHKIPAAHSGAVTCMWMNEQCSSI 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43367	NP_001189048.2	LamG	643..752	CDD:304605
		DUF4704	906..1162	CDD:292415
		DUF4800	1650..1899	CDD:292675	5/14 (36%)
		PH_BEACH	1952..2046	CDD:275391	18/97 (19%)
		Beach	2072..2351	CDD:280327	139/279 (50%)
		WD40	<2428..2734	CDD:225201	54/290 (19%)
		WD40 repeat	2465..2503	CDD:293791	10/43 (23%)
		WD40	2468..2687	CDD:295369	45/249 (18%)
		WD40 repeat	2509..2580	CDD:293791	20/123 (16%)
		WD40 repeat	2585..2621	CDD:293791	8/53 (15%)
nsmaf	XP_003199050.1	PH-like	184..277	CDD:302622	18/96 (19%)
		Beach	296..567	CDD:280327	139/279 (50%)
		WD40	<610..910	CDD:225201	60/314 (19%)
		WD40	620..908	CDD:238121	57/304 (19%)
		WD40 repeat	627..663	CDD:293791	9/44 (20%)
		WD40 repeat	669..705	CDD:293791	8/36 (22%)
		WD40 repeat	710..754	CDD:293791	3/43 (7%)
		WD40 repeat	760..795	CDD:293791	9/43 (21%)
		WD40 repeat	801..837	CDD:293791	8/44 (18%)
		WD40 repeat	883..907	CDD:293791	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1786
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D101142at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820